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HUTCHMED Highlights Clinical Data to be Presented at the 2025 World Conference of Lung Cancer and the CSCO Annual Meeting 2025

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HUTCHMED (Nasdaq/AIM:HCM) announced upcoming presentations of clinical data at two major conferences: the 2025 World Conference on Lung Cancer (WCLC) in Barcelona and the CSCO Annual Meeting 2025 in Jinan, China.

At WCLC, key presentations will focus on savolitinib, their MET tyrosine kinase inhibitor being developed with AstraZeneca, including updates from the SACHI and SAVANNAH trials in non-small cell lung cancer patients. At CSCO, HUTCHMED will present first-time data for HMPL-653, their novel CSF-1R inhibitor, from a Phase I study in tenosynovial giant cell tumor patients.

Additional presentations will cover multiple studies of fruquintinib and surufatinib across various cancer types, including colorectal, pancreatic, and neuroendocrine tumors, often in combination with other therapies.

HUTCHMED (Nasdaq/AIM:HCM) ha annunciato presentazioni imminenti di dati clinici in due grandi congressi: il 2025 World Conference on Lung Cancer (WCLC) a Barcellona e il CSCO Annual Meeting 2025 a Jinan, Cina.

Al WCLC le comunicazioni principali riguarderanno savolitinib, il loro inibitore della tirosina-chinasi MET sviluppato con AstraZeneca, con aggiornamenti dai trial SACHI e SAVANNAH nei pazienti con carcinoma polmonare non a piccole cellule. Al CSCO HUTCHMED presenterà per la prima volta i dati su HMPL-653, il loro nuovo inibitore di CSF-1R, ottenuti da uno studio di Fase I in pazienti con tumore gigante della guaina tenosinoviale.

Altre presentazioni copriranno vari studi su fruquintinib e surufatinib in diversi tipi di tumore, inclusi colon-retto, pancreas e tumori neuroendocrini, spesso in combinazione con altre terapie.

HUTCHMED (Nasdaq/AIM:HCM) anunció presentaciones próximos de datos clínicos en dos importantes congresos: el 2025 World Conference on Lung Cancer (WCLC) en Barcelona y el CSCO Annual Meeting 2025 en Jinan, China.

En el WCLC las presentaciones clave se centrarán en savolitinib, su inhibidor de la tirosina quinasa MET desarrollado con AstraZeneca, incluyendo actualizaciones de los ensayos SACHI y SAVANNAH en pacientes con cáncer de pulmón no microcítico. En el CSCO, HUTCHMED presentará por primera vez datos de HMPL-653, su novedoso inhibidor de CSF-1R, procedentes de un estudio de Fase I en pacientes con tumor gigante de la vaina tenosinovial.

Otras comunicaciones abordarán múltiples estudios sobre fruquintinib y surufatinib en diversos tipos de cáncer, incluidos colorrectal, pancreático y tumores neuroendocrinos, a menudo en combinación con otras terapias.

HUTCHMED (Nasdaq/AIM:HCM)� 바르셀로나에서 열리� 2025 World Conference on Lung Cancer (WCLC)와 중국 지난에� 개최되는 CSCO Annual Meeting 2025에서 임상 데이� 발표� 예정하고 있다� 발표했습니다.

WCLC에서� 아스트라제네카와 공동 개발 중인 MET 티로� 키나� 억제� savolitinib� 대� 주요 발표가 이루어지�, 비소세포폐암 환자� 대상으� � SACHI � SAVANNAH 임상시험� 업데이트가 포함됩니�. CSCO에서� HMPL-653라는 새로� CSF-1R 억제제에 대� 최초 데이터가 건초� 거대세포 종양(tenosynovial giant cell tumor) 환자� 대상으� � 1� 연구 결과� 공개됩니�.

추가 발표로는 fruquintinibsurufatinib� 다수 연구가 대장암, 췌장�, 신경내분비종� � 다양� 암종에서 다른 치료제와� 병용� 포함� 다뤄� 예정입니�.

HUTCHMED (Nasdaq/AIM:HCM) a annoncé la présentation prochaine de données cliniques lors de deux grandes conférences : la 2025 World Conference on Lung Cancer (WCLC) à Barcelone et le CSCO Annual Meeting 2025 à Jinan, Chine.

Lors du WCLC, les communications clés porteront sur savolitinib, leur inhibiteur de la tyrosine kinase MET développé avec AstraZeneca, incluant des mises à jour des essais SACHI et SAVANNAH chez des patients atteints de cancer du poumon non à petites cellules. Au CSCO, HUTCHMED présentera pour la première fois des données sur HMPL-653, leur nouvel inhibiteur de CSF-1R, issues d'une étude de phase I chez des patients atteints de tumeur géante des gaines tendineuses (tenosynovial).

D'autres présentations couvriront plusieurs études sur fruquintinib et surufatinib dans divers types de cancers, notamment colorectal, pancréatique et tumeurs neuroendocrines, souvent en association avec d'autres thérapies.

HUTCHMED (Nasdaq/AIM:HCM) gab bekannt, dass klinische Daten auf zwei großen Kongressen vorgestellt werden: der 2025 World Conference on Lung Cancer (WCLC) in Barcelona und dem CSCO Annual Meeting 2025 in Jinan, China.

Auf dem WCLC werden zentrale Präsentationen savolitinib betreffen, ihrem mit AstraZeneca entwickelten MET-Tyrosinkinase-Inhibitor, einschließlich Updates aus den SACHI- und SAVANNAH-Studien bei Patienten mit nicht-kleinzelligem Lungenkarzinom. Auf dem CSCO wird HUTCHMED erstmals Daten zu HMPL-653, ihrem neuen CSF-1R-Inhibitor, aus einer Phase-I-Studie bei Patienten mit tenosynovialem Riesenzelltumor vorstellen.

Weitere Präsentationen decken mehrere Studien zu fruquintinib und surufatinib bei verschiedenen Krebsarten ab, darunter kolorektale und Pankreas-Tumoren sowie neuroendokrine Tumoren, häufig in Kombination mit anderen Therapien.

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HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Sept. 05, 2025 (GLOBE NEWSWIRE) -- HUTCHMED (China) Limited (“�) (Nasdaq/AIM:​HCM; HKEX:�13) today announces that new and updated data from several studies of compounds discovered by HUTCHMED will be presented at the 2025 World Conference on Lung Cancer (“WCLC�) taking place on September 6-9, 2025 in Barcelona, Spain, and the Chinese Society of Clinical Oncology (“CSCO�) Annual Meeting 2025, taking place on September 10-14, 2025 in Jinan, China.

Updated analysis from savolitinib’s SACHI, SAVANNAH and a Phase IIIb confirmatory study in non-small cell lung cancer (“NSCLC�) patients will be presented at WCLC 2025. Savolitinibis an oral, potent and highly selective MET tyrosine kinase inhibitor (“TKI�) being jointly developed by AstraZeneca and HUTCHMED and commercialized by AstraZeneca. Details of the WCLC 2025 presentations are as follows:

Abstract titlePresenter / Lead authorPresentation details

SPONSORED STUDIES
SAVANNAH: Biomarker Concordance and Acquired Resistance in Patients with EGFRm MET-OverExp and / or Amp NSCLC

Christina Baik, University of Washington and Fred Hutchinson Cancer Center, Seattle, USA


Mini Oral: New Advances in Circulating Biomarkers
Room 06
Sunday, September 7, 2025
3:15 - 4:30PM CEST
Efficacy and Safety of Savolitinib in Advanced or Metastatic METex14 NSCLC Patients With or Without Prior Immunotherapy

Yongfeng Yu, Shanghai Chest Hospital, Shanghai, China


Poster: Metastatic NSCLC � Targeted Therapy
Tuesday, September 9, 2025
Frontline Treatment Duration in MET-Amplified NSCLC After Third-Generation EGFR-TKI Failure: SACHI Study Insights

Lijuan Chen, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China


Poster: Metastatic NSCLC � Targeted Therapy
Tuesday, September 9, 2025

Osimertinib + Savolitinib in EGFRm Advanced NSCLC With MET Overexp And/Or Amp Post-Progression on Osimertinib: SAVANNAH PROs

Silvia Novello, University of Turin, San Luigi Hospital, Turin, Italy


ePoster: Metastatic NSCLC � Targeted Therapy
Monday, September 8, 2025


INVESTIGATOR-INITIATED STUDIES
Efficacy and Safety of Surufatinib, Durvalumab in Combined with Chemotherapy as First-line Treatment of Extensive-stage Small-cell Lung CancerHui Zhang/ Ying Hu, Beijing Chest Hospital, Beijing, China
Poster: Small Cell Lung Cancer and Neuroendocrine Tumors
Tuesday, September 9, 2025


Clinical data of HMPL-653, a novel, selective and potent CSF-1R inhibitor, from a first-in-human Phase I study in patients with tenosynovial giant cell tumor in China will be presented for the first time at the CSCO Annual Meeting 2025.Details of the CSCO Annual Meeting 2025 presentations are as follows:

Abstract titlePresenter / Lead authorPresentation details

SPONSORED STUDIES
A first-in-human phase I study of HMPL-653, a CSF-1R inhibitor, in patients with tenosynovial giant cell tumorXiaohui Niu



25297
Oral Session
Friday, September 12, 2025
15:00 - 15:12PM HKT


INVESTIGATOR-INITIATED STUDIES
Fruquintinib Plus Serplulimab as First-Line Therapy in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (nccRCC): Updated Efficacy and Safety from a Multicenter, Single-Arm TrialJiwei Huang/ Wei Xue

23258
Oral Session
Thursday, September 11, 2025
16:50 - 17:15PM HKT
Fruquintinib plus camrelizumab combined with paclitaxel liposome and nedaplatin as first-line treatment for advanced esophageal squamous cell carcinoma (ESCC): updated data from a single-arm, phase II clinical trialTianzhu Qiu/ Yanhong Gu23766
Oral Session
Friday, September 12, 2025
11:20 - 12:00 noon HKT
Fruquintinib plus chemotherapy as second-line therapy in metastatic colorectal cancer: a multicenter, open-label, phase II clinical trialYongshun Chen

22084
Poster Session
Efficacy and Safety of Neoadjuvant Fruquintinib plus Toripalimab and Short-Course Radiotherapy (SCRT) for Locally Advanced Rectal Cancer: Updated Results from a Phase II Clinical TrialZhiping Li

21915
Abstract
Fruquintinib combined with chemotherapy as first-line treatment for advanced metastatic colorectal cancer: a propensity score-matched comparison of efficacy between a prospective single-arm cohort and a retrospective observational cohortFuxiang Zhou

23550
Abstract
Efficacy and safety of fruquintinib combined with PD-1 inhibitor and chidamide in MSS mCRC: a comparison with real-world bevacizumab plus anti-pd-1 and chidamide armMiaomiao Gou23591
Abstract
Phase ll Clinical Study of Surufatinib Combined with Gemcitabine and Cisplatin Plus Durvalumab/Pembrolizumab Regimen in the Treatment of Advanced Biliary Tract CancerMiaomiao Gou23610
Oral Session
Friday, September 12, 2025
16:53 - 16:59PM HKT
A single-arm, Phase Ib/II trial of surufatinib plus KN046 and gemcitabine and nab-paclitaxel as first-line treatment for unresectable advanced pancreatic cancerWenquan Wang/ Liang Liu

23783
Oral Session
Thursday, September 11, 2025
16:20 - 16:35PM HKT
Updated results of surufatinib plus transarterial embolization versus surufatinib monotherapy in neuroendocrine tumor with liver metastasis: a prospective, randomized, controlled trialDan Cao22652
Poster Session
Surufatinib in patients with soft tissue myeloma who have failed first-line standard chemotherapy or anlotinib: a multicenter, prospective, two-cohort, phase II clinical studyYuhong Zhou/ Xi GuoP80
Poster Session
Efficacy and Mechanistic Study of the NASCA Regimen (Surufatinib Combined with Camrelizumab, Nab-Paclitaxel, and S-1) in Advanced Pancreatic Cancer Patients with Liver MetastasisGuanghai Dai/ Ru Jia22309
Abstract
A Phase II, Single-Arm Study of Surufatinib Combined with Zimberelimab and Nab-Paclitaxel in Patients with Advanced Triple-Negative Breast Cancer: Data UpdateCaixia Wang

23679
Abstract
Efficacy and safety of surufatinib combined with gemcitabine, cisplatin and immune checkpoint inhibitor for the treatment of unresectable locally advanced or metastatic intrahepatic cholangiocarcinomaXuetao Shi/ Jingtao Zhong24133
Abstract
Efficacy and Safety of Surufatinib in Patients with Neuroendocrine Neoplasms: A Multicenter Retrospective StudyJiang Long24294
Abstract


About HUTCHMED

HUTCHMED (Nasdaq/AIM:​HCM; HKEX:�13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery and global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Since inception it has focused on bringing drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, the first of which is also approved around the world including in the US, Europe and Japan. For more information, please visit: or follow us on .

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor� provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect HUTCHMED’s current expectations regarding future events, including but not limited to its expectations regarding the therapeutic potential of fruquintinib, surufatinib, savolitinib and HMPL-653, the further clinical development for fruquintinib, surufatinib, savolitinib and HMPL-653, its expectations as to whether any studies on fruquintinib, surufatinib, savolitinib and HMPL-653 would meet their primary or secondary endpoints, and its expectations as to the timing of the completion and the release of results from such studies. Such risks and uncertainties include, among other things, assumptions regarding enrollment rates and the timing and availability of subjects meeting a study’s inclusion and exclusion criteria; changes to clinical protocols or regulatory requirements; unexpected adverse events or safety issues; the ability of fruquintinib, surufatinib, savolitinib and HMPL-653, including as combination therapies, to meet the primary or secondary endpoint of a study, to obtain regulatory approval in different jurisdictions and to gain commercial acceptance after obtaining regulatory approval; the potential markets of fruquintinib, surufatinib, savolitinib and HMPL-653 for a targeted indication, and the sufficiency of funding. In addition, as certain studies rely on the use of other drug productsas combination therapeutics, such risks and uncertainties include assumptions regarding their safety, efficacy, supply and continued regulatory approval. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. For further discussion of these and other risks, see HUTCHMED’s filings with the US Securities and Exchange Commission, The Stock Exchange of Hong Kong Limited and on AIM. HUTCHMED undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.

Medical Information

This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.

CONTACTS

Investor Enquiries+85221218200 / [email protected]
Media Enquiries
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Brunswick � Zhou Yi+85297836894(Mobile)/ [email protected]
Panmure LiberumNominated Advisor and Joint Broker
Atholl Tweedie/ Emma Earl/ Rupert Dearden+442078862500
CavendishJoint Broker
Geoff Nash/ Nigel Birks+442072200500
Deutsche NumisJoint Broker
Freddie Barnfield / Jeffrey Wong / Duncan Monteith+44 20 7260 1000

FAQ

When and where will HUTCHMED present its clinical data at WCLC 2025?

HUTCHMED will present at the World Conference on Lung Cancer (WCLC) from September 6-9, 2025 in Barcelona, Spain.

What is the main focus of HCM's presentations at WCLC 2025?

The presentations will focus on savolitinib, including updated analyses from the SACHI and SAVANNAH trials in non-small cell lung cancer (NSCLC) patients.

What new data will HUTCHMED present at CSCO 2025?

HUTCHMED will present first-time data from a Phase I study of HMPL-653, their novel CSF-1R inhibitor, in patients with tenosynovial giant cell tumor.

What is the collaboration between HUTCHMED and AstraZeneca for savolitinib?

Savolitinib is being jointly developed by HUTCHMED and AstraZeneca, with AstraZeneca handling the commercialization of the drug.

When is the CSCO Annual Meeting 2025 and what will HCM present there?

The CSCO Annual Meeting takes place September 10-14, 2025 in Jinan, China, where HUTCHMED will present data on multiple compounds including HMPL-653, fruquintinib, and surufatinib across various cancer types.
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