Natera Highlights Latest Prospera鈩� Data at WTC 2025; 16 Abstracts Including Five Oral Presentations
High-impact datasets across heart, kidney and lung at WTC follows two major publications in the American Journal of Transplantation in the last three months
The presentations span kidney, heart and lung transplantation and represent one of the most comprehensive collections of data on Natera鈥檚 Prospera test to date. Highlights include five oral presentations and 11 poster sessions featuring evidence from high-impact studies that support the use of Natera鈥檚 products, such as:
- Multiple abstracts from the Trifecta series of studies, including three oral presentations which evaluated Prospera鈥檚 performance across kidney, heart and lung transplantation.
- Two posters tied to recently published studies in the American Journal of Transplantation: (1) The prospective, multi-center PEDAL clinical trial, which demonstrated Prospera Kidney鈥檚 ability to predict long-term outcomes following rejection; and (2) a study on Prospera Heart with Donor Quantity Score (DQS), highlighting its robust performance in detecting allograft rejection.
- An oral presentation detailing Prospera Kidney鈥檚 utility in monitoring treatment of chronic antibody-mediated rejection with anti-CD38 monoclonal antibody therapy. These findings were published earlier this month in Kidney International Reports.
鈥淲e are proud to share 16 presentations across kidney, heart and lung at this major global conference,鈥� said Sangeeta Bhorade, M.D., chief medical officer of organ health at Natera. 鈥淭hese new presentations and recent peer-reviewed publications underscore the clinical value of Prospera and affirm our leadership in advancing transplant care through innovation and science.鈥�
Full list of presentations at WTC include:
August 3, 5:35 PM PT | Presentation # OA11.8 (Oral Presentation)
Presenter: Patrick T. Gauthier, Ph.D.
Trifecta-Lung Study: dd-cfDNA Correlates with T Cell-Mediated Rejection and Parenchymal Injury in Mucosal Biopsies of Lung Transplants
August 4, 3:30 PM PT | Presentation # P2.07.92
Presenter: Vasanthi Balaraman, M.D.
Role of Broad Gene Panel for Kidney Disease in Kidney Transplant Donor Selection: A Case Study
August 4, 3:30 PM PT | Presentation # P2.07.165
Presenter: Yasar Caliskan, M.D.
Experiences Regarding Use of Genetic Testing in Living Donor Candidate Evaluation: A Survey of US Transplant Center Staff
August 4, 3:30 PM PT | Presentation # P2.07.198
Presenter: Katelynn S. Madill-Thomsen, Ph.D.
Calling All DSA Positive Allows Existing Banff Guidelines to Diagnose Many More Cases of Histologic ABMR Currently Missed Only Because They Are DSA-Negative
August 4, 4:41 PM PT | Presentation # OA18.2 (Oral Presentation)
Presenter: Krista Lentine, M.D., Ph.D.
Contemporary Practice and Challenges in Managing the Costs of Kidney Paired Donation: A Survey of US Transplant Professionals
August 5, 3:30 PM PT | Presentation # P3.03.50
Presenter: Suphamai Bunnapradist, M.D.
Monitoring the Response to Treatment of Kidney Allograft Rejection with Donor-Derived Cell-Free DNA
August 5, 3:30 PM PT | Presentation # P3.03.55
Presenter: Paul J. Kim, M.D.
A Two-Threshold Algorithm Using Donor-Derived Cell-Free DNA Fraction and Quantity to Detect Acute Rejection After 21 Days Post Heart Transplantation
August 5, 3:30 PM PT | Presentation # P3.03.56
Presenter: Alan Betensley, M.D., BSE, FCCP
Monitoring Changes in Donor-Derived Cell-Free DNA Levels in Treated Lung Allograft Rejection: Pilot Data
August 5, 3:30 PM PT | Presentation # P3.03.57
Presenter: David J. Ross, M.D., FCCP, FAST
Cell-Free DNA Does Not Discriminate Acute Rejection from Infection After Lung Transplant: Pilot Study
August 5, 3:30 PM PT | Presentation # P3.03.58
Presenter: Katherine Vandervest, M.D.
鈥楤aseline Lung Allograft Dysfunction鈥� is Associated with Different Cell-Free DNA Dynamics After Lung Transplantation
August 5, 3:30 PM PT | Presentation # P3.03.59
Presenter: Eileen Hsich, M.D.
Donor-Derived Cell-Free DNA is Not Associated with White Blood Cell Count in Heart Transplant Recipients
August 5, 3:30 PM PT | Presentation # P3.03.60
Presenter: Navchetan Kaur, Ph.D.
Trajectory of dd-cfDNA Levels in Patients Undergoing Repeat Kidney Transplantation
August 5, 3:30 PM PT | Presentation # P3.07.177
Presenter: Ziad S. Zaky, M.D.
Unsupervised Machine Learning with Dynamic Time Warping Helps Understand Longitudinal dd-cfDNA Trajectories in Kidney Transplant Patients
August 5, 4:41 PM PT | Presentation # OA36.2 (Oral Presentation)
Presenter: Katelynn S. Madill-Thomsen, Ph.D.
Defining Relationships Among Tests for Heart Transplant Antibody-Mediated Rejection
August 6, 8:44 AM PT | Presentation # OA50.4 (Oral Presentation)
Presenter: Katelynn S. Madill-Thomsen, Ph.D.
Defining the Hierarchy of Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection
August 6, 9:20 AM PT | Presentation # OA50.8 (Oral Presentation)
Presenter: Wai-Choong Lye, M.D.
Anti-CD38 Monoclonal Antibody Daratumumab for the Treatment of Chronic Active-Antibody Mediated Kidney Allograft Rejection
About Natera
Natera鈩� is a global leader in cell-free DNA and genetic testing, dedicated to oncology, women鈥檚 health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera鈥檚 tests are supported by more than 300 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in
Forward-Looking Statements
All statements other than statements of historical facts contained in this press release are forward-looking statements and are not a representation that Natera鈥檚 plans, estimates, or expectations will be achieved. These forward-looking statements represent Natera鈥檚 expectations as of the date of this press release, and Natera disclaims any obligation to update the forward-looking statements. These forward-looking statements are subject to known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect to whether the results of clinical or other studies will support the use of our product offerings, the impact of results of such studies, our expectations of the reliability, accuracy and performance of our tests, or of the benefits of our tests and product offerings to patients, providers and payers. Additional risks and uncertainties are discussed in greater detail in 鈥淩isk Factors鈥� in Natera鈥檚 recent filings on Forms 10-K and 10-Q and in other filings Natera makes with the SEC from time to time. These documents are available at and .
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Investor Relations: Mike Brophy, CFO, Natera, Inc., [email protected]
Media: Lesley Bogdanow, VP of Corporate Communications, Natera, Inc., [email protected]
Source: Natera, Inc.
