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[Form 4] Praxis Precision Medicines, Inc. Insider Trading Activity

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
4
Rhea-AI Filing Summary

Praxis Precision Medicines, Inc. (PRAX) � Form 4 insider filing

Director Jill DeSimone received a new option grant on 26 June 2025. The grant covers 10,520 shares of common stock at an exercise price of $44.04 and expires on 26 June 2035. Vesting is scheduled in twelve equal monthly installments over one year beginning on the grant date, aligning compensation with near-term company performance. After this transaction Ms. DeSimone holds 10,520 derivative securities directly. No common-stock transactions, sales, or additional option exercises were reported.

The filing represents a routine equity incentive for a non-employee director and does not change PRAX’s share count in a material way. The transaction code "A" confirms an acquisition of options rather than an open-market purchase, so immediate cash outlay or insider buy-signal implications are minimal.

Praxis Precision Medicines, Inc. (PRAX) � Comunicazione interna Modulo 4

La direttrice Jill DeSimone ha ricevuto una nuova concessione di opzioni il 26 giugno 2025. L'assegnazione riguarda 10.520 azioni ordinarie con un prezzo di esercizio di 44,04 $ e scade il 26 giugno 2035. La maturazione avverrà in dodici rate mensili uguali nell'arco di un anno a partire dalla data di concessione, allineando la remunerazione alla performance aziendale a breve termine. Dopo questa operazione, la signora DeSimone detiene direttamente 10.520 strumenti derivati. Non sono state segnalate transazioni in azioni ordinarie, vendite o ulteriori esercizi di opzioni.

La comunicazione rappresenta un incentivo azionario di routine per una direttrice non dipendente e non modifica in modo sostanziale il numero di azioni PRAX in circolazione. Il codice transazione "A" conferma un acquisto di opzioni piuttosto che un acquisto sul mercato aperto, quindi l'esborso immediato o segnali di acquisto da parte dell’insider sono minimi.

Praxis Precision Medicines, Inc. (PRAX) � Presentación interna Formulario 4

La directora Jill DeSimone recibió una nueva concesión de opciones el 26 de junio de 2025. La concesión cubre 10,520 acciones ordinarias a un precio de ejercicio de $44.04 y vence el 26 de junio de 2035. La ܾó se otorgará en doce cuotas mensuales iguales durante un año a partir de la fecha de concesión, alineando la compensación con el desempeño de la empresa a corto plazo. Tras esta transacción, la Sra. DeSimone posee directamente 10,520 valores derivados. No se reportaron transacciones, ventas ni ejercicios adicionales de opciones sobre acciones ordinarias.

La presentación representa un incentivo de capital rutinario para una directora no empleada y no cambia de manera significativa el número de acciones de PRAX. El código de transacción "A" confirma una ܾó de opciones en lugar de una compra en el mercado abierto, por lo que el desembolso inmediato o las implicaciones de señales de compra por parte del insider son mínimas.

Praxis Precision Medicines, Inc. (PRAX) � 내부� 보고� Form 4

이사 Jill DeSimone2025� 6� 26�� 새로� 스톡옵션� 부여받았습니다. � 부여는 10,520� 보통�� 대� 행사 갶� $44.04이며 만료일은 2035� 6� 26�입니�. 베스팅은 부여일로부� 1년간 매달 동일� 12� 분할� 이루어져 단기 회사 성과와 보상� 연계합니�. � 거래 � DeSimone 이사� 직접 10,520개의 파생 증권� 보유하게 됩니�. 보통� 거래, 매도 또는 추갶� 옵션 행사 내역은 보고되지 않았습니�.

� 보고� 비직� 이사� 대� 일상적인 주식 인센티브이며 PRAX 주식 수에 � 변동을 주지 않습니다. 거래 코드 "A"� 공개 시장 매입� 아닌 옵션 취득임을 확인하며, 즉각적인 현금 지출이� 내부� 매수 신호� 영향은 미미합니�.

Praxis Precision Medicines, Inc. (PRAX) � Déclaration d’initié Formulaire 4

La directrice Jill DeSimone a reçu une nouvelle attribution d’options le 26 juin 2025. Cette attribution porte sur 10 520 actions ordinaires à un prix d’exercice de 44,04 $ et expire le 26 juin 2035. La période d’acquisition est prévue en douze versements mensuels égaux sur un an à compter de la date d’attribution, alignant ainsi la rémunération sur la performance à court terme de l’entreprise. Après cette opération, Mme DeSimone détient directement 10 520 titres dérivés. Aucune transaction, vente ou exercice supplémentaire d’options sur actions ordinaires n’a été signalé.

Cette déclaration représente une incitation en actions de routine pour une administratrice non salariée et ne modifie pas de manière significative le nombre d’actions PRAX. Le code de transaction « A » confirme une acquisition d’options plutôt qu’un achat sur le marché ouvert, ce qui minimise les sorties de trésorerie immédiates ou les implications d’un signal d’achat de la part de l’initié.

Praxis Precision Medicines, Inc. (PRAX) � Insider-Meldung Formular 4

Die Direktorin Jill DeSimone erhielt am 26. Juni 2025 eine neue Optionszuteilung. Die Zuteilung umfasst 10.520 Stammaktien zu einem Ausübungspreis von 44,04 $ und läuft am 26. Juni 2035 ab. Die Vesting erfolgt in zwölf gleichen monatlichen Raten über ein Jahr ab dem Zuteilungsdatum, wodurch die Vergütung an die kurzfristige Unternehmensleistung gekoppelt wird. Nach dieser Transaktion hält Frau DeSimone direkt 10.520 derivative Wertpapiere. Es wurden keine Transaktionen mit Stammaktien, Verkäufe oder weitere Optionsausübungen gemeldet.

Die Meldung stellt einen routinemäßigen Aktienanreiz für einen nicht angestellten Direktor dar und verändert die Anzahl der PRAX-Aktien nicht wesentlich. Der Transaktionscode "A" bestätigt einen Erwerb von Optionen und keinen Kauf am offenen Markt, sodass sofortige Barausgaben oder Insider-Kaufsignale minimal sind.

Positive
  • None.
Negative
  • None.

Insights

TL;DR: Standard director option grant; aligns incentives, immaterial to float.

This Form 4 reflects a customary annual equity award for an independent director. The one-year monthly vesting schedule incentivises short-term engagement without over-leveraging equity compensation. With only 10.5 k options granted, the potential dilution is de minimis relative to PRAX’s ~47 m shares outstanding. No red flags appear regarding grant size or pricing; the strike at $44.04 mirrors recent market levels, preserving accounting neutrality under ASC 718. Impact on governance quality is modestly positive but financially negligible.

TL;DR: Neutral—routine compensation, no buy/sell signal.

The filing does not indicate insider confidence through open-market buying; it is a scheduled option grant coded "A". Because the award has a 10-year term and vests monthly, the director is not likely to exercise imminently, so no liquidity event is expected. Investors should view this as administrative rather than indicative of near-term fundamentals. Overall share-based compensation expense will rise slightly, but at this scale EPS impact rounds to zero.

Praxis Precision Medicines, Inc. (PRAX) � Comunicazione interna Modulo 4

La direttrice Jill DeSimone ha ricevuto una nuova concessione di opzioni il 26 giugno 2025. L'assegnazione riguarda 10.520 azioni ordinarie con un prezzo di esercizio di 44,04 $ e scade il 26 giugno 2035. La maturazione avverrà in dodici rate mensili uguali nell'arco di un anno a partire dalla data di concessione, allineando la remunerazione alla performance aziendale a breve termine. Dopo questa operazione, la signora DeSimone detiene direttamente 10.520 strumenti derivati. Non sono state segnalate transazioni in azioni ordinarie, vendite o ulteriori esercizi di opzioni.

La comunicazione rappresenta un incentivo azionario di routine per una direttrice non dipendente e non modifica in modo sostanziale il numero di azioni PRAX in circolazione. Il codice transazione "A" conferma un acquisto di opzioni piuttosto che un acquisto sul mercato aperto, quindi l'esborso immediato o segnali di acquisto da parte dell’insider sono minimi.

Praxis Precision Medicines, Inc. (PRAX) � Presentación interna Formulario 4

La directora Jill DeSimone recibió una nueva concesión de opciones el 26 de junio de 2025. La concesión cubre 10,520 acciones ordinarias a un precio de ejercicio de $44.04 y vence el 26 de junio de 2035. La ܾó se otorgará en doce cuotas mensuales iguales durante un año a partir de la fecha de concesión, alineando la compensación con el desempeño de la empresa a corto plazo. Tras esta transacción, la Sra. DeSimone posee directamente 10,520 valores derivados. No se reportaron transacciones, ventas ni ejercicios adicionales de opciones sobre acciones ordinarias.

La presentación representa un incentivo de capital rutinario para una directora no empleada y no cambia de manera significativa el número de acciones de PRAX. El código de transacción "A" confirma una ܾó de opciones en lugar de una compra en el mercado abierto, por lo que el desembolso inmediato o las implicaciones de señales de compra por parte del insider son mínimas.

Praxis Precision Medicines, Inc. (PRAX) � 내부� 보고� Form 4

이사 Jill DeSimone2025� 6� 26�� 새로� 스톡옵션� 부여받았습니다. � 부여는 10,520� 보통�� 대� 행사 갶� $44.04이며 만료일은 2035� 6� 26�입니�. 베스팅은 부여일로부� 1년간 매달 동일� 12� 분할� 이루어져 단기 회사 성과와 보상� 연계합니�. � 거래 � DeSimone 이사� 직접 10,520개의 파생 증권� 보유하게 됩니�. 보통� 거래, 매도 또는 추갶� 옵션 행사 내역은 보고되지 않았습니�.

� 보고� 비직� 이사� 대� 일상적인 주식 인센티브이며 PRAX 주식 수에 � 변동을 주지 않습니다. 거래 코드 "A"� 공개 시장 매입� 아닌 옵션 취득임을 확인하며, 즉각적인 현금 지출이� 내부� 매수 신호� 영향은 미미합니�.

Praxis Precision Medicines, Inc. (PRAX) � Déclaration d’initié Formulaire 4

La directrice Jill DeSimone a reçu une nouvelle attribution d’options le 26 juin 2025. Cette attribution porte sur 10 520 actions ordinaires à un prix d’exercice de 44,04 $ et expire le 26 juin 2035. La période d’acquisition est prévue en douze versements mensuels égaux sur un an à compter de la date d’attribution, alignant ainsi la rémunération sur la performance à court terme de l’entreprise. Après cette opération, Mme DeSimone détient directement 10 520 titres dérivés. Aucune transaction, vente ou exercice supplémentaire d’options sur actions ordinaires n’a été signalé.

Cette déclaration représente une incitation en actions de routine pour une administratrice non salariée et ne modifie pas de manière significative le nombre d’actions PRAX. Le code de transaction « A » confirme une acquisition d’options plutôt qu’un achat sur le marché ouvert, ce qui minimise les sorties de trésorerie immédiates ou les implications d’un signal d’achat de la part de l’initié.

Praxis Precision Medicines, Inc. (PRAX) � Insider-Meldung Formular 4

Die Direktorin Jill DeSimone erhielt am 26. Juni 2025 eine neue Optionszuteilung. Die Zuteilung umfasst 10.520 Stammaktien zu einem Ausübungspreis von 44,04 $ und läuft am 26. Juni 2035 ab. Die Vesting erfolgt in zwölf gleichen monatlichen Raten über ein Jahr ab dem Zuteilungsdatum, wodurch die Vergütung an die kurzfristige Unternehmensleistung gekoppelt wird. Nach dieser Transaktion hält Frau DeSimone direkt 10.520 derivative Wertpapiere. Es wurden keine Transaktionen mit Stammaktien, Verkäufe oder weitere Optionsausübungen gemeldet.

Die Meldung stellt einen routinemäßigen Aktienanreiz für einen nicht angestellten Direktor dar und verändert die Anzahl der PRAX-Aktien nicht wesentlich. Der Transaktionscode "A" bestätigt einen Erwerb von Optionen und keinen Kauf am offenen Markt, sodass sofortige Barausgaben oder Insider-Kaufsignale minimal sind.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
DeSimone Jill

(Last) (First) (Middle)
C/O PRAXIS PRECISION MEDICINES, INC.
99 HIGH STREET, 30TH FLOOR

(Street)
BOSTON MA 02110

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Praxis Precision Medicines, Inc. [ PRAX ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
06/26/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $44.04 06/26/2025 A 10,520 (1) 06/26/2035 Common Stock 10,520 $0 10,520 D
Explanation of Responses:
1. The shares subject to this option shall vest in twelve (12) equal monthly installments over one (1) year commencing on June 26, 2025.
Remarks:
/s/ Alex Nemiroff, as Attorney-in-Fact 06/27/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Praxis Precision Medicines (PRAX) report on this Form 4?

An option grant of 10,520 shares to director Jill DeSimone at an exercise price of $44.04, dated 26 Jun 2025.

Does the filing show any insider buying or selling of PRAX common stock?

No. It discloses only an option acquisition; there were no direct stock purchases or sales.

When do the options granted to Jill DeSimone vest and expire?

They vest in 12 equal monthly installments over one year starting 26 Jun 2025 and expire on 26 Jun 2035.

How many derivative securities does the director own after the transaction?

Ms. DeSimone beneficially owns 10,520 stock options following the reported grant.

Is the transaction likely to materially dilute existing PRAX shareholders?

Dilution is immaterial; 10,520 options represent far less than 1% of outstanding shares.
Praxis Precision Medicines, Inc.

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882.59M
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9.03%
Biotechnology
Pharmaceutical Preparations
United States
BOSTON