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Taysha Gene Therapies, Inc. SEC Filings

TSHA NASDAQ

Welcome to our dedicated page for Taysha Gene Therapies SEC filings (Ticker: TSHA), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.

Decoding how an AAV gene-therapy startup finances multi-million-dollar trials and mitigates overexpression risks can feel impossible. Taysha Gene Therapies� SEC disclosures span technical manufacturing details, RMAT negotiations and complex stock-based compensation—critical points easily missed when you skim 200-page reports.

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Rhea-AI Summary

The Schedule 13G filed on 27 June 2025 discloses that The Goldman Sachs Group, Inc. and its affiliate Goldman Sachs & Co. LLC have acquired beneficial ownership of 12,748,968 shares of Taysha Gene Therapies, Inc. (TSHA) common stock. The position represents 5.1 % of TSHA’s outstanding shares, crossing the 5 % reporting threshold under Section 13(d) of the Securities Exchange Act.

All voting and dispositive authority over the shares is reported as shared; neither entity claims sole authority. The filing is on Schedule 13G, indicating a passive investment rather than an effort to influence control, as confirmed by the Item 10 certification.

Goldman Sachs & Co. LLC is classified as a broker-dealer, other organization, and investment adviser, while The Goldman Sachs Group, Inc. is identified as a holding company/control person. No additional group members or activist exhibits are included.

The disclosure confirms meaningful institutional ownership by a globally recognized financial institution, potentially improving share liquidity and lending credibility to TSHA. However, because it is a passive filing, it does not imply forthcoming strategic or operational changes at the issuer.

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FAQ

What is the current stock price of Taysha Gene Therapies (TSHA)?

The current stock price of Taysha Gene Therapies (TSHA) is $2.45 as of July 3, 2025.

What is the market cap of Taysha Gene Therapies (TSHA)?

The market cap of Taysha Gene Therapies (TSHA) is approximately 630.3M.

What is the primary focus of Taysha Gene Therapies, Inc.?

Taysha Gene Therapies focuses on developing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system, including rare conditions like Rett syndrome.

Which technology platform does TSHA use for its gene therapies?

TSHA employs a proven AAV9 vector platform combined with miRNA-Responsive Auto-Regulatory Element (miRARE) technology to deliver functional genes on a cell-by-cell basis in the CNS.

How does Taysha differentiate itself in the biotechnology market?

The company differentiates itself by specializing in CNS monogenic disorders, leveraging innovative AAV-based technology, robust manufacturing processes, and strategic academic partnerships to bridge preclinical research with clinical development.

What are some key product candidates in TSHA's pipeline?

Key candidates include TSHA-102 for Rett syndrome, along with other programs targeting GM2 gangliosidosis, CLN1 disease, SLC6A1 haploinsufficiency disorder, and Surfeit Locus 1 deficiency.

What regulatory designations has TSHA achieved for its lead candidate?

TSHA-102 has received designations such as Regenerative Medicine Advanced Therapy (RMAT), Fast Track, and Orphan Drug status, underscoring its potential to address unmet clinical needs.

Who are the likely stakeholders or customers for TSHA's therapies?

Stakeholders include patients suffering from rare genetic disorders, healthcare providers, academic and research institutions, and investors interested in innovative biopharmaceutical solutions.

How do strategic partnerships enhance TSHA's capabilities?

Collaborations, such as those with notable academic institutions, strengthen TSHA’s research and development efforts, improve clinical data collection, and help streamline the regulatory process for its novel therapies.

What role does TSHA's experienced management team play?

The management team brings deep expertise in gene therapy development and commercialization, ensuring that the company’s innovative products are advanced efficiently from the laboratory to the clinic.
Taysha Gene Therapies, Inc.

NASDAQ:TSHA

TSHA Rankings

TSHA Stock Data

630.29M
231.01M
18.34%
82.14%
12.45%
Biotechnology
Biological Products, (no Disgnostic Substances)
United States
DALLAS