AGÕæÈ˹ٷ½

STOCK TITAN

[Form 4] Zymeworks Inc. Insider Trading Activity

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
4
Rhea-AI Filing Summary

EcoR1 Capital, LLC, together with its affiliated fund and managing member Oleg Nodelman, filed a Form 4 disclosing the cashless exercise of 5,086,521 pre-funded warrants in Zymeworks Inc. (ticker: ZYME) on 26 Jun 2025.

  • The warrants carried a nominal exercise price of $0.0001 per share. To settle the aggregate exercise price, the reporting persons instructed the issuer to withhold 41 shares (valued at $12.71 each), issuing the remaining 5,086,480 new common shares.
  • Following the transaction, EcoR1’s Qualified Fund owns 21,582,563 ZYME shares and the group reports total indirect beneficial ownership of 22,970,388 shares.
  • The derivative position (pre-funded warrants) is now fully exhausted; the reporting persons hold 0 derivative securities post-transaction.
  • EcoR1 and Mr. Nodelman are both classified as 10% owners and hold board seats, reinforcing their strategic involvement with the company.

The filing signals continued insider alignment through an increase in equity exposure; however, it also converts previously outstanding warrants into issued equity, modestly expanding the public float.

EcoR1 Capital, LLC, insieme al suo fondo affiliato e al membro gestore Oleg Nodelman, ha depositato un Modulo 4 rivelando l'esercizio senza pagamento in contanti di 5.086.521 warrant pre-finanziati in Zymeworks Inc. (ticker: ZYME) il 26 giugno 2025.

  • I warrant avevano un prezzo nominale di esercizio di $0,0001 per azione. Per regolare il prezzo complessivo di esercizio, le persone che hanno effettuato la comunicazione hanno istruito l'emittente a trattenere 41 azioni (valutate $12,71 ciascuna), emettendo le restanti 5.086.480 nuove azioni ordinarie.
  • A seguito della transazione, il Fondo Qualificato di EcoR1 possiede 21.582.563 azioni ZYME e il gruppo dichiara una proprietà indiretta totale di 22.970.388 azioni.
  • La posizione derivata (warrant pre-finanziati) è ora completamente esaurita; le persone che hanno effettuato la comunicazione detengono 0 titoli derivati dopo la transazione.
  • EcoR1 e il Sig. Nodelman sono entrambi classificati come proprietari del 10% e occupano seggi nel consiglio di amministrazione, rafforzando il loro coinvolgimento strategico con la società.

La comunicazione segnala un continuo allineamento degli insider attraverso un aumento dell'esposizione azionaria; tuttavia, converte anche warrant precedentemente in circolazione in azioni emesse, ampliando modestamente il flottante pubblico.

EcoR1 Capital, LLC, junto con su fondo afiliado y el miembro gerente Oleg Nodelman, presentó un Formulario 4 revelando el ejercicio sin efectivo de 5,086,521 warrants prefinanciados en Zymeworks Inc. (ticker: ZYME) el 26 de junio de 2025.

  • Los warrants tenían un precio nominal de ejercicio de $0.0001 por acción. Para saldar el precio total de ejercicio, las personas que informaron instruyeron al emisor retener 41 acciones (valoradas en $12.71 cada una), emitiendo las restantes 5,086,480 nuevas acciones ordinarias.
  • Tras la transacción, el Fondo Calificado de EcoR1 posee 21,582,563 acciones de ZYME y el grupo reporta una propiedad indirecta total de 22,970,388 acciones.
  • La posición derivada (warrants prefinanciados) está ahora completamente agotada; las personas que informaron no poseen ²Ô¾±²Ô²µÃº²Ô valor derivado tras la transacción.
  • EcoR1 y el Sr. Nodelman están clasificados como propietarios del 10% y ocupan puestos en la junta directiva, reforzando su participación estratégica en la compañía.

La presentación indica una continua alineación interna mediante un aumento en la exposición accionaria; sin embargo, también convierte warrants previamente pendientes en acciones emitidas, ampliando modestamente el flotante público.

EcoR1 Capital, LLCëŠ� 계열 펀ë“� ë°� ê´€ë¦� 멤버 Oleg Nodelmanê³� 함께 2025ë…� 6ì›� 26ì� Zymeworks Inc.(티커: ZYME)ì—서 5,086,521ê°œì˜ ì„ ì§€ê¸� ì›ŒëŸ°íŠ¸ì˜ í˜„ê¸ˆ 없는 행사 ë‚´ìš©ì� ë‹´ì€ Form 4ë¥� 제출했습니다.

  • ì›ŒëŸ°íŠ¸ì˜ ëª…ëª© 행사 ê°€ê²©ì€ ì£¼ë‹¹ $0.0001ì´ì—ˆìŠµë‹ˆë‹�. ì´� 행사 ëŒ€ê¸ˆì„ ì •ì‚°í•˜ê¸° 위해 ë³´ê³ ìžëŠ” ë°œí–‰ì‚¬ì— 41ì£�(주당 $12.71 ê°€ì¹�)ë¥� ì›ì²œì§•수하ë„ë¡� 지시하ê³�, 나머지 5,086,480ì£¼ì˜ ì‹ ì£¼ 보통ì£�ë¥� 발행했습니다.
  • 거래 í›� EcoR1ì� ì ê²© 펀드는 21,582,563ì£�ì� ZYME 주ì‹ì� 보유하고 있으ë©�, ê·¸ë£¹ì€ ì´� ê°„ì ‘ 소유 ì§€ë¶� 22,970,388ì£�ë¥� 보고합니ë‹�.
  • 파ìƒìƒí’ˆ í¬ì§€ì…�(ì„ ì§€ê¸� 워런íŠ�)ì€ ì´ì œ 완전íž� 소진ë˜ì—ˆìœ¼ë©°, ë³´ê³ ìžëŠ” 거래 í›� 0ê°œì˜ íŒŒìƒìƒí’ˆì� 보유하고 있습니다.
  • EcoR1ê³� Nodelman 씨는 ëª¨ë‘ 10% 소유ì£�ë¡� 분류ë˜ë©° ì´ì‚¬íšŒì—ë� 참여하여 회사와ì� ì „ëžµì � 연계ë¥� 강화하고 있습니다.

ì´ë²ˆ ì œì¶œì€ ì§€ë¶� 노출 ì¦ê°€ë¥� 통한 ë‚´ë¶€ìž� ê°� ì§€ì†ì ì� ì •ë ¬ì� 나타내지ë§�, ë™ì‹œì—� 기존ì—� ë¯¸ê²°ì œëœ ì›ŒëŸ°íŠ¸ë¥¼ 발행 주ì‹ìœ¼ë¡œ 전환하여 공모 유통 ì£¼ì‹ ìˆ˜ë¥¼ 다소 확대합니ë‹�.

EcoR1 Capital, LLC, avec son fonds affilié et le membre gestionnaire Oleg Nodelman, a déposé un formulaire 4 révélant l'exercice sans numéraire de 5 086 521 bons de souscription préfinancés dans Zymeworks Inc. (symbole : ZYME) le 26 juin 2025.

  • Les bons avaient un prix d'exercice nominal de 0,0001 $ par action. Pour régler le prix d'exercice global, les déclarants ont demandé à l'émetteur de retenir 41 actions (valorisées à 12,71 $ chacune), émettant les 5 086 480 nouvelles actions ordinaires restantes.
  • À la suite de la transaction, le fonds qualifié d'EcoR1 détient 21 582 563 actions ZYME et le groupe déclare une propriété indirecte totale de 22 970 388 actions.
  • La position dérivée (bons préfinancés) est désormais entièrement épuisée ; les déclarants ne détiennent plus aucun titre dérivé après la transaction.
  • EcoR1 et M. Nodelman sont tous deux classés comme détenteurs de 10 % et siègent au conseil d'administration, renforçant leur implication stratégique dans la société.

Le dépôt signale une continuité dans l'alignement des initiés grâce à une augmentation de l'exposition en actions ; cependant, il convertit également des bons précédemment en circulation en actions émises, élargissant modestement le flottant public.

EcoR1 Capital, LLC hat zusammen mit seinem verbundenen Fonds und dem geschäftsführenden Mitglied Oleg Nodelman am 26. Juni 2025 ein Formular 4 eingereicht, das die bargeldlose Ausübung von 5.086.521 vorfinanzierten Warrants bei Zymeworks Inc. (Ticker: ZYME) offenlegt.

  • Die Warrants hatten einen nominalen Ausübungspreis von $0,0001 pro Aktie. Zur Begleichung des Gesamt-Ausübungspreises wiesen die meldenden Personen den Emittenten an, 41 Aktien (jeweils im Wert von $12,71) einzubehalten und die verbleibenden 5.086.480 neuen Stammaktien auszugeben.
  • Nach der Transaktion besitzt der qualifizierte Fonds von EcoR1 21.582.563 ZYME-Aktien, und die Gruppe meldet einen gesamten indirekten wirtschaftlichen Eigentum von 22.970.388 Aktien.
  • Die Derivatposition (vorfinanzierte Warrants) ist nun vollständig erschöpft; die meldenden Personen halten nach der Transaktion 0 derivative Wertpapiere.
  • EcoR1 und Herr Nodelman sind beide als 10%-·¡¾±²µ±ð²Ô³Ùü³¾±ð°ù klassifiziert und besitzen Sitze im Vorstand, was ihr strategisches Engagement im Unternehmen unterstreicht.

Die Meldung signalisiert eine fortgesetzte Insider-Ausrichtung durch eine Erhöhung der Aktienexponierung; gleichzeitig werden zuvor ausstehende Warrants in ausgegebene Aktien umgewandelt, wodurch der Streubesitz moderat erweitert wird.

Positive
  • Insider confidence: 10% owner EcoR1 converted 5.1 M warrants, increasing its direct equity exposure.
  • Removal of derivative overhang: All pre-funded warrants are now exercised, simplifying capital structure.
  • Enhanced alignment: Board-affiliated investor now holds 22.97 M common shares, strengthening governance accountability.
Negative
  • Share count increase: Issuance of 5.09 M new shares marginally dilutes existing shareholders.
  • No cash inflow: Nominal $0.0001 exercise price yields de-minimis capital to the company.

Insights

TL;DR: EcoR1 converted 5.1 M pre-funded warrants, boosting its common share stake to 23 M and eliminating warrant overhang.

The warrant exercise adds 5.1 M shares to the outstanding count at a de-minimis cost, indicating EcoR1’s ongoing commitment as a long-term holder. Because pre-funded warrants are typically included in diluted share calculations, the impact on fully-diluted EPS is likely limited. Nonetheless, the shift from derivative to common stock removes execution risk and signals insider confidence, which investors often interpret positively. The small share withholding (41 shares) to cover exercise costs is immaterial. Overall, this is a constructive insider transaction with negligible cash inflow to the company.

TL;DR: Director/10% owner deepens equity stake, reinforcing governance influence.

EcoR1 and Oleg Nodelman already hold board representation; converting the warrants increases their voting power by roughly 5 million shares, further entrenching their influence. Because the exercise price is negligible, there is no meaningful capital contribution to the issuer, but the move aligns board and shareholder interests by turning options into vested ownership. No new compensation or dilution beyond what was already disclosed under the warrant terms arises. Overall governance impact is positive due to stronger insider alignment, with limited negative effects apart from a minor uptick in issued share count.

EcoR1 Capital, LLC, insieme al suo fondo affiliato e al membro gestore Oleg Nodelman, ha depositato un Modulo 4 rivelando l'esercizio senza pagamento in contanti di 5.086.521 warrant pre-finanziati in Zymeworks Inc. (ticker: ZYME) il 26 giugno 2025.

  • I warrant avevano un prezzo nominale di esercizio di $0,0001 per azione. Per regolare il prezzo complessivo di esercizio, le persone che hanno effettuato la comunicazione hanno istruito l'emittente a trattenere 41 azioni (valutate $12,71 ciascuna), emettendo le restanti 5.086.480 nuove azioni ordinarie.
  • A seguito della transazione, il Fondo Qualificato di EcoR1 possiede 21.582.563 azioni ZYME e il gruppo dichiara una proprietà indiretta totale di 22.970.388 azioni.
  • La posizione derivata (warrant pre-finanziati) è ora completamente esaurita; le persone che hanno effettuato la comunicazione detengono 0 titoli derivati dopo la transazione.
  • EcoR1 e il Sig. Nodelman sono entrambi classificati come proprietari del 10% e occupano seggi nel consiglio di amministrazione, rafforzando il loro coinvolgimento strategico con la società.

La comunicazione segnala un continuo allineamento degli insider attraverso un aumento dell'esposizione azionaria; tuttavia, converte anche warrant precedentemente in circolazione in azioni emesse, ampliando modestamente il flottante pubblico.

EcoR1 Capital, LLC, junto con su fondo afiliado y el miembro gerente Oleg Nodelman, presentó un Formulario 4 revelando el ejercicio sin efectivo de 5,086,521 warrants prefinanciados en Zymeworks Inc. (ticker: ZYME) el 26 de junio de 2025.

  • Los warrants tenían un precio nominal de ejercicio de $0.0001 por acción. Para saldar el precio total de ejercicio, las personas que informaron instruyeron al emisor retener 41 acciones (valoradas en $12.71 cada una), emitiendo las restantes 5,086,480 nuevas acciones ordinarias.
  • Tras la transacción, el Fondo Calificado de EcoR1 posee 21,582,563 acciones de ZYME y el grupo reporta una propiedad indirecta total de 22,970,388 acciones.
  • La posición derivada (warrants prefinanciados) está ahora completamente agotada; las personas que informaron no poseen ²Ô¾±²Ô²µÃº²Ô valor derivado tras la transacción.
  • EcoR1 y el Sr. Nodelman están clasificados como propietarios del 10% y ocupan puestos en la junta directiva, reforzando su participación estratégica en la compañía.

La presentación indica una continua alineación interna mediante un aumento en la exposición accionaria; sin embargo, también convierte warrants previamente pendientes en acciones emitidas, ampliando modestamente el flotante público.

EcoR1 Capital, LLCëŠ� 계열 펀ë“� ë°� ê´€ë¦� 멤버 Oleg Nodelmanê³� 함께 2025ë…� 6ì›� 26ì� Zymeworks Inc.(티커: ZYME)ì—서 5,086,521ê°œì˜ ì„ ì§€ê¸� ì›ŒëŸ°íŠ¸ì˜ í˜„ê¸ˆ 없는 행사 ë‚´ìš©ì� ë‹´ì€ Form 4ë¥� 제출했습니다.

  • ì›ŒëŸ°íŠ¸ì˜ ëª…ëª© 행사 ê°€ê²©ì€ ì£¼ë‹¹ $0.0001ì´ì—ˆìŠµë‹ˆë‹�. ì´� 행사 ëŒ€ê¸ˆì„ ì •ì‚°í•˜ê¸° 위해 ë³´ê³ ìžëŠ” ë°œí–‰ì‚¬ì— 41ì£�(주당 $12.71 ê°€ì¹�)ë¥� ì›ì²œì§•수하ë„ë¡� 지시하ê³�, 나머지 5,086,480ì£¼ì˜ ì‹ ì£¼ 보통ì£�ë¥� 발행했습니다.
  • 거래 í›� EcoR1ì� ì ê²© 펀드는 21,582,563ì£�ì� ZYME 주ì‹ì� 보유하고 있으ë©�, ê·¸ë£¹ì€ ì´� ê°„ì ‘ 소유 ì§€ë¶� 22,970,388ì£�ë¥� 보고합니ë‹�.
  • 파ìƒìƒí’ˆ í¬ì§€ì…�(ì„ ì§€ê¸� 워런íŠ�)ì€ ì´ì œ 완전íž� 소진ë˜ì—ˆìœ¼ë©°, ë³´ê³ ìžëŠ” 거래 í›� 0ê°œì˜ íŒŒìƒìƒí’ˆì� 보유하고 있습니다.
  • EcoR1ê³� Nodelman 씨는 ëª¨ë‘ 10% 소유ì£�ë¡� 분류ë˜ë©° ì´ì‚¬íšŒì—ë� 참여하여 회사와ì� ì „ëžµì � 연계ë¥� 강화하고 있습니다.

ì´ë²ˆ ì œì¶œì€ ì§€ë¶� 노출 ì¦ê°€ë¥� 통한 ë‚´ë¶€ìž� ê°� ì§€ì†ì ì� ì •ë ¬ì� 나타내지ë§�, ë™ì‹œì—� 기존ì—� ë¯¸ê²°ì œëœ ì›ŒëŸ°íŠ¸ë¥¼ 발행 주ì‹ìœ¼ë¡œ 전환하여 공모 유통 ì£¼ì‹ ìˆ˜ë¥¼ 다소 확대합니ë‹�.

EcoR1 Capital, LLC, avec son fonds affilié et le membre gestionnaire Oleg Nodelman, a déposé un formulaire 4 révélant l'exercice sans numéraire de 5 086 521 bons de souscription préfinancés dans Zymeworks Inc. (symbole : ZYME) le 26 juin 2025.

  • Les bons avaient un prix d'exercice nominal de 0,0001 $ par action. Pour régler le prix d'exercice global, les déclarants ont demandé à l'émetteur de retenir 41 actions (valorisées à 12,71 $ chacune), émettant les 5 086 480 nouvelles actions ordinaires restantes.
  • À la suite de la transaction, le fonds qualifié d'EcoR1 détient 21 582 563 actions ZYME et le groupe déclare une propriété indirecte totale de 22 970 388 actions.
  • La position dérivée (bons préfinancés) est désormais entièrement épuisée ; les déclarants ne détiennent plus aucun titre dérivé après la transaction.
  • EcoR1 et M. Nodelman sont tous deux classés comme détenteurs de 10 % et siègent au conseil d'administration, renforçant leur implication stratégique dans la société.

Le dépôt signale une continuité dans l'alignement des initiés grâce à une augmentation de l'exposition en actions ; cependant, il convertit également des bons précédemment en circulation en actions émises, élargissant modestement le flottant public.

EcoR1 Capital, LLC hat zusammen mit seinem verbundenen Fonds und dem geschäftsführenden Mitglied Oleg Nodelman am 26. Juni 2025 ein Formular 4 eingereicht, das die bargeldlose Ausübung von 5.086.521 vorfinanzierten Warrants bei Zymeworks Inc. (Ticker: ZYME) offenlegt.

  • Die Warrants hatten einen nominalen Ausübungspreis von $0,0001 pro Aktie. Zur Begleichung des Gesamt-Ausübungspreises wiesen die meldenden Personen den Emittenten an, 41 Aktien (jeweils im Wert von $12,71) einzubehalten und die verbleibenden 5.086.480 neuen Stammaktien auszugeben.
  • Nach der Transaktion besitzt der qualifizierte Fonds von EcoR1 21.582.563 ZYME-Aktien, und die Gruppe meldet einen gesamten indirekten wirtschaftlichen Eigentum von 22.970.388 Aktien.
  • Die Derivatposition (vorfinanzierte Warrants) ist nun vollständig erschöpft; die meldenden Personen halten nach der Transaktion 0 derivative Wertpapiere.
  • EcoR1 und Herr Nodelman sind beide als 10%-·¡¾±²µ±ð²Ô³Ùü³¾±ð°ù klassifiziert und besitzen Sitze im Vorstand, was ihr strategisches Engagement im Unternehmen unterstreicht.

Die Meldung signalisiert eine fortgesetzte Insider-Ausrichtung durch eine Erhöhung der Aktienexponierung; gleichzeitig werden zuvor ausstehende Warrants in ausgegebene Aktien umgewandelt, wodurch der Streubesitz moderat erweitert wird.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
EcoR1 Capital, LLC

(Last) (First) (Middle)
357 TEHAMA STREET #3

(Street)
SAN FRANCISCO CA 94103

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Zymeworks Inc. [ ZYME ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
06/26/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/26/2025 X 5,086,480(2) A $0.0001 22,970,388(3) I See Note(1)
Common Stock 06/26/2025 F(4) 41 D $12.71 22,970,388(3) I See Note(1)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Pre-Funded Warrants (right to acquire) $0.0001 06/26/2025 X 5,086,521(5) 12/26/2023 (6) Common Stock 5,086,521 $0 0 I See note(1)
1. Name and Address of Reporting Person*
EcoR1 Capital, LLC

(Last) (First) (Middle)
357 TEHAMA STREET #3

(Street)
SAN FRANCISCO CA 94103

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer
X Director X 10% Owner
Officer (give title below) Other (specify below)
1. Name and Address of Reporting Person*
NODELMAN OLEG

(Last) (First) (Middle)
357 TEHAMA STREET #3

(Street)
SAN FRANCISCO CA 94103

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer
X Director X 10% Owner
Officer (give title below) Other (specify below)
Explanation of Responses:
1. The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.
2. Qualified Fund acquired 4,818,424 shares of Common Stock in connection with the exercise of the pre-funded warrants.
3. After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock.
4. On June 26, 2025,the reporting persons exercised pre-funded warrants to purchase 5,086,521 shares of the Issuer's Common Stock for $0.0001 per share. The reporting persons paid the exercise price on a cashless basis, resulting in the Issuer withholding 41 of the warrant shares (including 38 warrant shares issuable to Qualified Fund) to pay the exercise price and issuing to the reporting persons the remaining 5,086,480 shares.
5. Qualified Fund exercised 4,818,462 of the pre-funded warrants reported in this transaction.
6. The pre-funded warrants did not have an expiration date.
Remarks:
Mr. Nodelman is a director of the Issuer. Scott Platshon, an employee of EcoR1, also serves as a director of the Issuer and was nominated for the board by EcoR1 and the Funds.
/s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC 06/27/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many ZYME shares did EcoR1 acquire on 26 Jun 2025?

EcoR1 received 5,086,480 additional common shares after netting 41 shares for the exercise price.

What is EcoR1’s total ownership in Zymeworks after the Form 4 transaction?

The group now reports indirect beneficial ownership of 22,970,388 common shares.

Were any derivative securities still outstanding after the warrant exercise?

No. The 5,086,521 pre-funded warrants were fully exercised, leaving 0 derivative securities.

Did Zymeworks receive significant cash from the warrant exercise?

No. The warrants had a $0.0001 per-share price, resulting in immaterial cash proceeds.

Does EcoR1 hold board representation at Zymeworks?

Yes. Oleg Nodelman and EcoR1 employee Scott Platshon serve as directors of the issuer.
Zymeworks

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Biotechnology
Pharmaceutical Preparations
United States
MIDDLETOWN