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• End of treatment (EOT) data from Cohort 4 of the听ENSURE听study suggest that patients responding to prior BRII-179 treatment achieved faster and higher rate of surface antigen clearance with curative treatments compared to BRII-179 na茂ve participants, strengthening the case for a novel听enrichment strategy, utilizing听BRII-179 to听identify听and prime patients for improved functional cure outcomes
• 24 Week follow-up results from Cohorts 1-3 of the ENSURE study demonstrated sustained off-treatment benefits of elebsiran + PEG-IFN伪 combination therapy vs PEG-IFN伪 alone

DURHAM, N.C. and BEIJING, May 7, 2025 /PRNewswire/ -- ("Brii Bio" or the "Company", stock code: 2137.HK), a biotechnology company developing therapies to improve patient health and choice across diseases with high unmet medical need, today announced data from its ongoing Phase 2 ENSURE study听as late-breaking posters at the European Association for the Study of the Liver (EASL) Congress 2025 in Amsterdam, the Netherlands.

ENSURE (NCT05970289) is a multicenter, open-label听Phase 2 study. Cohorts 1-3 were designed to evaluate the contribution of elebsiran, an investigational small interfering ribonucleic acid (siRNA), to the combination treatment with pegylated interferon alpha (PEG-IFN伪) in participants with chronic HBV infection with baseline hepatitis B surface antigen (HBsAg) of 100-3,000 IU/mL.

Cohort 4 enrolled participants who completed 9 doses of BRII-179, a recombinant protein-based therapeutic vaccine,听in combination with elebsiran in a previous APAC study BRII-179-835-001 (NCT04749368) to receive elebsiran and PEG-IFN伪 combination treatment. These participants were grouped based on their anti-HBs response induced by prior BRII-179 treatment: those with peak anti-HBs titers 鈮� 10 IU/L are defined as anti-HBs responders, and those with peak anti-HBs titers < 10 IU/L as non-responders. The design of Cohort 4 as part of this study was based on the insight that BRII-179 could differentiate between immune responders and non-responders, offering the potential to predict future response to therapy.

Interim听data听from听Cohort 4 showed that anti-HBs responders achieved a substantially higher rate of HBsAg seroclearance than non-responders.听At EOT (Week 48), 61% (11/18) of anti-HBs responders achieved HBsAg seroclearance, compared to 10% (1/10) of non-responders. Among the 11 anti-HBs responders who achieved HBsAg loss, 91% (10/11) had anti-HBs titers 鈮� 100 IU/L at EOT.

Of note, BRII-179 experienced participants in Cohort 4 achieved HBsAg loss faster than BRII-179 na茂ve听participants in Cohort 2 and 3. 83% (10/12) of HBsAg loss in BRII-179 experienced participants occurred by Week 24, compared to 55% (6/11) in BRII-179 na茂ve participants. These findings suggest rapid HBsAg seroclearance in subjects with higher anti-HBs titers may translate into durable HBsAg loss and the potential to evaluate shorter treatment durations of PEG-IFN伪.

Additional data from Cohorts 1-3 of the ENSURE study showed the combination therapy of elebsiran either 100 mg or 200 mg and PEG-IFN伪 resulted in higher HBsAg loss rate at 24 weeks post EOT compared to PEG-IFN伪 alone, supporting the additive benefit of siRNA.

"The data from Cohort 4 of the ENSURE study are encouraging. We saw in target populations that patients who were immune-responsive through pre-treatment with BRII-179 demonstrated a significant advantage in听achieving听a higher HBsAg seroclearance rate," said David Margolis, MD, Chief Medical Officer of Brii Bio. "With BRII-179, we may identify patients with less impaired intrinsic immunity and further prime their immune response. This approach may provide more durable HBsAg loss and potentially shorter treatment duration of PEG-IFN伪. We are moving full speed ahead with our clinical efforts to deliver a meaningful option to the chronic hepatitis B patients long left waiting."

Abstract Number:听LB25123/ LBP-018

罢颈迟濒别:听Chronic hepatitis B virus infected participants responding to prior BRII-179 treatment achieved faster and higher rate of hepatitis B virus surface antigen seroclearance on elebsiran plus pegylated interferon-alfa: end of treatment data from ENSURE study

Presenter:听Grace Lai-Hung Wong, MBChB (CUHK), MD (CUHK), FRCP (Lond, Edin), FHKCP, FHKAM (Medicine), Professor of Gastroenterology and Hepatology at CUHK Medical Data Analytics Centre (MDAC) and Department of Medicine and Therapeutics听in Hong Kong SAR, China

• A total of 28 participants with baseline听HBsAg > 100 and 鈮� 3000 IU/mL were analyzed. 18 and 10 participants had peak anti-HBs titer 鈮� 10 IU/L (defined as anti-HBs responders) and < 10 IU/L (defined as non-responders) induced by BRII-179 in the previous study, respectively.
• Median [range]听HBsAg at the time of initiating elebsiran + PEG-IFN伪 was numerically higher in anti-HBs responders (539.4 [106.7-2165.0] IU/mL) than in non-responders (219.3 [106.7-671.5] IU/mL). At EOT (Week 48), 61% (11/18) of anti-HBs responders achieved HBsAg seroclearance, compared to 10% (1/10) of non-responders.
• Among the听anti-HBs responders who lost HBsAg, 91% (10/11) had anti-HBs titers 鈮� 100 IU/L at EOT.
• BRII-179 experienced participants achieved听HBsAg loss faster than BRII-179 na茂ve participants, with 83% (10/12) of HBsAg loss occurring by Week 24 (vs 55% [6/11] in BRII-179 na茂ve participants).
• Elebsiran + PEG-IFN伪 was generally safe and tolerated in BRII-179 experienced participants.

Abstract Number:听LB25115/ LBP-016
Title: Efficacy and safety of elebsiran and pegylated interferon alfa combination therapy versus pegylated interferon alfa in participants with chronic hepatitis B virus infection: follow-up results from the ongoing phase 2, randomized, open-label ENSURE study
Presenter:听David Margolis, MD, MPH, Chief Medical Officer of Brii Biosciences

• At Week 72 (24 weeks post听EOT), higher HBsAg loss rate was observed in participants on combination therapy of either elebsiran 200mg or 100 mg and PEG-IFN伪 compared to PEG-IFN伪 alone (21.1% [4/19] or 33.3% [6/18] vs 5.6% [1/18]). 听All the 11 participants with HBsAg loss had baseline HBsAg < 1500 IU/mL.
• Incidence of treatment emergent adverse events (TEAEs) was comparable between combination therapy cohorts and PEG-IFN伪 alone cohort. Most TEAEs were consistent with known side effects of PEG-IFN伪.

As part of Brii Bio's unique approach to developing a functional cure for HBV, the Company and its partners are actively progressing multiple combination studies with our differentiated portfolio, including听BRII-179 being evaluated in multiple combination studies with elebsiran led by Brii Bio; elebsiran being evaluated in combination with PEG-IFN伪 in studies led by Brii Bio;听and tobevibart, an investigational broadly neutralizing monoclonal antibody targeting HBV, being evaluated in multiple Phase 2 and 3 tobevibart and elebsiran combination studies led by Vir Biotechnology.听Key data readouts will be shared in the coming months at scientific conferences throughout 2025.

About Hepatitis B

Hepatitis B virus (HBV) infection is one of the world's most significant infectious disease threats with more than 254 million people infected globally.^[1] Chronic HBV infection is the leading cause of liver disease and an estimated 820,000 people die of complications from chronic HBV infection each year.^[1]听HBV is of exceptional concern in China, where 87 million people are chronically infected.^[2]

About BRII-179

BRII-179 is a novel recombinant protein-based HBV immunotherapeutic candidate that expresses the Pre-S1, Pre-S2, and S HBV surface antigens, and is designed to induce enhanced and broad B-cell and T-cell immunity. In November 2023, the Center for Drug Evaluation (the "CDE") of the National Medical Products Administration (the "NMPA") granted BRII-179 Breakthrough Therapy Designation.

About Elebsiran (previously known as BRII-835, VIR-2218)

Elebsiran is an investigational subcutaneously听administered HBV-targeting siRNA designed to degrade hepatitis B virus RNA transcripts and听limit the production of hepatitis B surface antigen. It has the potential to have direct antiviral听activity against HBV and HDV. It is the first siRNA in the clinic to include Enhanced Stabilization听Chemistry Plus technology to enhance stability and minimize off-target activity, which potentially听can result in an increased therapeutic index. Brii Bio听licensed exclusive rights to develop and听commercialize elebsiran for the听Greater China territory from Vir Biotechnology, Inc. in 2020.

About Brii Bio

Brii Biosciences Limited ("Brii Bio", stock code: 2137.HK) is a biotechnology company developing therapies to address major public health challenges where patients experience high unmet medical needs, limited choice and significant social stigmas. With a focus on infectious diseases, the Company is advancing a broad pipeline of unique therapeutic candidates with lead programs against hepatitis B virus (HBV) infection. The Company is led by a visionary and experienced leadership team and has operations in key biotech hubs, including Raleigh-Durham, the San Francisco Bay Area, Beijing and Shanghai. For more information, visit .

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