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Early data from robust Autonomy Phase 2b posdinemab trial demonstrate Company's leadership in multimodal biomarkers and early detection

New findings highlight the central role of tau in disease progression, bolstering confidence in the Company's industry-leading anti-tau portfolio

Featured research session to share new findings from GNPC, the world's largest neurodegenerative disease proteomics resource, co-founded with Gates Ventures

TITUSVILLE, N.J., July 24, 2025 /PRNewswire/ -- Johnson & Johnson (NYSE: JNJ) today announced promising new data from its Alzheimer's disease (AD) research program will be presented at the Alzheimer's Association International Conference (AAIC), taking place July 27鈥�31 in Toronto, Canada. Across 12 abstracts, the Company will share听颈苍sight into how tau impacts brain function in early AD and reinforce the predictive strength of plasma biomarker pTau217 for tracking cognitive decline in at-risk individuals. The Company will also introduce findings from the Global Neurodegeneration Proteomics Consortium听(GNPC), a public-private partnership co-founded by Johnson & Johnson and Gates Ventures, the private office of Bill Gates.

"Our long-standing leadership in Alzheimer's disease research gives us critical perspective on where the field has been and where it needs to go," said Bill Martin, Ph.D., Global Therapeutic Area Head, Neuroscience, Johnson & Johnson. "These data reflect how we are reconceptualizing the way we diagnose and treat disorders that are among the most prevalent and debilitating of our time, underscoring our unmatched legacy of advancing neuroscience and improving lives, and bringing us closer to a future where Alzheimer's disease may one day be a thing of the past."

Following the July 15 听颈苍 Nature Medicine and Nature Aging, and the public release of the GNPC dataset, leaders from Johnson & Johnson and Gates Ventures will host a featured research session at AAIC to share new findings from the world's largest neurodegenerative disease proteomics resource.听

"Long-standing challenges in assembling large, diverse datasets have made progress in understanding the biology of neurodegenerative diseases extremely slow. At AAIC, we are sharing how the GNPC is enabling discovery at scale," said Niranjan Bose, Ph.D., Managing Director, Health & Life Sciences at Gates Ventures. "Even at this early stage, researchers are uncovering new insights into some of the most studied risk factors, highlighting the power of the GNPC to drive discovery, reveal new targets, and ultimately accelerate progress for the more than 57 million people living with Alzheimer's disease and other dementias worldwide."

The following Company-sponsored and Company-partnered abstracts will be presented at AAIC 2025:

ABOUT ALZHEIMER'S DISEASE (AD) & DEMENTIA
Alzheimer's disease (AD), the most common form of dementia worldwide, is a fatal neurodegenerative disorder characterized by progressive memory loss and a decline in other cognitive abilities severe enough to significantly interfere with daily life.¹ Diagnostic criteria for AD are based on established classifications but continue to evolve as research advances. Preclinical AD refers to individuals with detectable AD pathology (amyloid and tau) who are cognitively unimpaired. Early AD includes individuals with mild cognitive impairment due to AD (also known as prodromal AD) and mild Alzheimer's dementia.

As AD advances, patients experience worsening cognitive decline, eventually losing the ability to perform basic tasks, communicate or recognize loved ones, ultimately leading to death.¹ There is no cure for AD, and despite several new advancements, significant unmet need remains across the spectrum of this devastating disease.

ABOUT POSDINEMAB
Posdinemab is an investigational monoclonal antibody that is designed to target the mid-domain of AD-specific phosphorylated tau. Posdinemab is designed to bind to pathological phosphorylated tau when it is released from neurons and neutralize it before it can seed/spread to another neuron. The internally-discovered antibody has shown promise in reducing tau seeding鈥攖he process by which toxic tau spreads through the brain鈥攊n both in vitro and in vivo non-clinical studies.

The Phase 2b "AuTonomy" study investigating posdinemab in participants with early AD is fully enrolled and ongoing ().

ABOUT JOHNSON & JOHNSON
At听Johnson & Johnson,听we believe health is everything. Our strength in healthcare innovation empowers us to build a听world where complex diseases are prevented, treated, and cured,听where treatments are smarter and less invasive, and听where solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.听

Learn more at听听or at听

Follow us at听@JNJInnovMed.

Janssen Research & Development, LLC is a Johnson & Johnson company.

CAUTIONS CONCERNING FORWARD-LOOKING STATEMENTS
This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of posdinemab. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products, and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of healthcare products and services; changes to applicable laws and regulations, including global healthcare reforms; and trends toward healthcare cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's most recent Annual Report on Form 10-K, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at , or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statement as a result of new information or future events or developments.

漏 Johnson & Johnson 2025. All rights reserved.

Media contact:
Allie Prull
Johnson & Johnson
[email protected]

Investor contact:
Lauren Johnson
Johnson & Johnson
investor-relations@its.jnj.com

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