Plus Therapeutics Reports Second Quarter Financial Results and Recent Business Highlights
Plus Therapeutics (NASDAQ:PSTV) reported Q2 2025 financial results and significant progress in its CNS cancer treatment programs. The company achieved net income of $5.2 million ($0.02 per share), compared to a net loss of $2.9 million in Q2 2024, primarily due to derivative instruments valuation changes. Cash position strengthened to $6.9 million as of June 30, 2025.
Key developments include the initiation of the REYOBIQ dose optimization trial for leptomeningeal metastases treatment and FDA clearance for pediatric brain cancer treatment. The company also announced the commercial launch of its CNSide CSF assay platform in Texas, targeting a $6 billion U.S. market, with plans for national expansion. Additionally, Plus completed restructuring of its $15 million equity financing and received a $1.6 million CPRIT grant payment.
Plus Therapeutics (NASDAQ:PSTV) ha reso noti i risultati finanziari del secondo trimestre 2025 e i progressi nei programmi di trattamento dei tumori del SNC. La societ脿 ha registrato un utile netto di 5,2 milioni di dollari (0,02 $ per azione), rispetto a una perdita netta di 2,9 milioni nel Q2 2024, principalmente a causa di rivalutazioni di strumenti derivati. La posizione di cassa 猫 salita a 6,9 milioni di dollari al 30 giugno 2025.
Tra gli sviluppi principali, 猫 stato avviato lo studio di ottimizzazione della dose REYOBIQ per le metastasi leptomeningee e ottenuta l'approvazione FDA per il trattamento dei tumori cerebrali pediatrici. L'azienda ha anche annunciato il lancio commerciale della sua piattaforma di test CNSide CSF in Texas, puntando a un mercato statunitense da 6 miliardi di dollari, con piani di espansione nazionale. Inoltre, Plus ha completato la ristrutturazione di un finanziamento azionario da 15 milioni di dollari e ricevuto un pagamento di 1,6 milioni di dollari da CPRIT.
Plus Therapeutics (NASDAQ:PSTV) inform贸 los resultados financieros del segundo trimestre de 2025 y avances significativos en sus programas para c谩ncer del SNC. La compa帽铆a obtuvo un ingreso neto de 5,2 millones de d贸lares (0,02 $ por acci贸n), frente a una p茅rdida neta de 2,9 millones en el Q2 de 2024, principalmente debido a ajustes en la valoraci贸n de instrumentos derivados. La posici贸n de efectivo se fortaleci贸 hasta 6,9 millones de d贸lares al 30 de junio de 2025.
Entre los hitos clave figura el inicio del ensayo de optimizaci贸n de dosis REYOBIQ para el tratamiento de met谩stasis leptomen铆ngeas y la aprobaci贸n de la FDA para el tratamiento de tumores cerebrales pedi谩tricos. La compa帽铆a tambi茅n anunci贸 el lanzamiento comercial de su plataforma de ensayo CNSide CSF en Texas, apuntando a un mercado estadounidense de 6.000 millones de d贸lares, con planes de expansi贸n nacional. Adem谩s, Plus complet贸 la reestructuraci贸n de un financiamiento de capital por 15 millones de d贸lares y recibi贸 un pago de 1,6 millones de d贸lares de CPRIT.
Plus Therapeutics (NASDAQ:PSTV)電� 2025雲� 2攵勱赴 鞛鞁れ爜瓿� 欷戩稊鞁犼步瓿�(CNS) 鞎� 旃橂 頂勲攴鸽灗鞚� 欤检殧 歆勳爠鞚� 氚滍憸頄堨姷雼堧嫟. 須岇偓電� 靾滌澊鞚� 520毵� 雼煬(欤茧嫻 0.02雼煬)毳� 旮半頄堨溂氅�, 鞚措姅 2024雲� 2攵勱赴 靾滌啇鞁� 290毵� 雼煬鞐愳劀鞚� 臧滌劆鞙茧, 欤茧 韺岇儩靸來拡 韽夑皜 氤�霃欖棎 旮办澑頃╇媹雼�. 2025雲� 6鞗� 30鞚� 旮办 順勱笀 氤挫湢鞎§潃 690毵� 雼煬搿� 臧曧檾霅橃棃鞀惦媹雼�.
欤检殧 歆勴枆靷暛鞙茧電� 霠堨澊鞓る箙(REYOBIQ) 觳欖垬毵夓爠鞚挫 鞖╇焿 斓滌爜頇� 鞛勳儊鞁滍棙 臧滌嫓鞕� 靻岇晞 雵岇鞏� 旃橂鞐� 雽�頃� FDA 鞀轨澑 須嶋摑鞚� 韽暔霅╇媹雼�. 霕愴暅 韰嶌偓鞀れ棎靹� CNSide CSF 攵勳劃 頂岆灚韽�鞚� 靸侅梾鞝� 於滌嫓毳� 氚滍憸頄堨溂氅�, 氙戈淡 鞁滌灔 攴滊 60鞏� 雼煬毳� 氇╉憸搿� 鞝勱淡 頇曥灔 瓿勴殟鞚� 靾橂頄堨姷雼堧嫟. 於旉皜搿� Plus電� 1,500毵� 雼煬 攴滊鞚� 欤检嫕 鞛愱笀 臁半嫭 甑“臁办爼鞚� 鞕勲頃橁碃 160毵� 雼煬鞚� CPRIT 氤挫“旮� 歆�旮夓潉 氚涭晿鞀惦媹雼�.
Plus Therapeutics (NASDAQ:PSTV) a publi茅 ses r茅sultats financiers du deuxi猫me trimestre 2025 et des progr猫s notables dans ses programmes de traitement des cancers du SNC. La soci茅t茅 a enregistr茅 un r茅sultat net de 5,2 millions de dollars (0,02 $ par action), contre une perte nette de 2,9 millions au T2 2024, principalement en raison de r茅茅valuations d'instruments d茅riv茅s. La tr茅sorerie s'est renforc茅e 脿 6,9 millions de dollars au 30 juin 2025.
Parmi les d茅veloppements cl茅s figurent le lancement de l'essai d'optimisation de dose REYOBIQ pour le traitement des m茅tastases leptomening茅es et l'autorisation de la FDA pour le traitement des tumeurs c茅r茅brales p茅diatriques. La soci茅t茅 a 茅galement annonc茅 le lancement commercial de sa plateforme d'analyse CNSide CSF au Texas, visant un march茅 am茅ricain de 6 milliards de dollars, avec des plans d'expansion nationale. De plus, Plus a finalis茅 la restructuration d'un financement en actions de 15 millions de dollars et re莽u un paiement CPRIT de 1,6 million de dollars.
Plus Therapeutics (NASDAQ:PSTV) berichtete 眉ber die Finanzergebnisse des zweiten Quartals 2025 und bedeutende Fortschritte in seinen Therapieprogrammen f眉r ZNS-Tumoren. Das Unternehmen erzielte einen Nettoertrag von 5,2 Mio. USD (0,02 USD je Aktie) im Vergleich zu einem Nettoverlust von 2,9 Mio. USD im Q2 2024, haupts盲chlich bedingt durch Neubewertungen von Derivaten. Die Zahlungsmittelposition verbesserte sich auf 6,9 Mio. USD zum 30. Juni 2025.
Wesentliche Entwicklungen umfassen den Start der REYOBIQ-Dosisoptimierungsstudie f眉r die Behandlung leptomeningealer Metastasen sowie die FDA-Freigabe f眉r die Behandlung p盲diatrischer Hirntumoren. Das Unternehmen gab au脽erdem den kommerziellen Start seiner CNSide CSF Assay-Plattform in Texas bekannt und zielt auf einen US-Markt im Wert von 6 Milliarden USD ab, mit Pl盲nen zur landesweiten Expansion. Zus盲tzlich schloss Plus die Umstrukturierung einer 15 Mio. USD Eigenkapitalfinanzierung ab und erhielt eine 1,6 Mio. USD CPRIT-Zahlung.
- Net income improved to $5.2 million in Q2 2025 from -$2.9 million loss in Q2 2024
- Operating loss reduced to $1.5 million from $3.7 million year-over-year
- Cash position increased to $6.9 million from $3.6 million at year-end 2024
- Received $1.6 million CPRIT grant payment from $17.6 million total grant
- FDA clearance received for REYOBIQ pediatric brain cancer treatment
- CNSide platform targeting $6 billion U.S. market opportunity
- Significant portion of net income ($6.5 million) came from non-operational derivative value changes
- Commercial launch limited to Texas initially, with delayed national rollout
- Operating losses continue despite reduction
Insights
Plus Therapeutics shows promising progress with REYOBIQ radiotherapy for CNS cancers and upcoming CNSide diagnostic launch, despite ongoing financial challenges.
Plus Therapeutics is making meaningful clinical progress with its REYOBIQ radiotherapeutic platform for central nervous system cancers. The interim data presented at the Nuclear Medicine and Neuro-oncology conference showed encouraging safety and clinical benefit signals in patients with leptomeningeal metastases (LM), a notoriously difficult-to-treat condition with poor prognosis. The initiation of the dose optimization trial, advancing beyond single-dose studies to multiple-dose regimens via intraventricular catheter, represents a critical development milestone.
The FDA clearance for REYOBIQ in pediatric patients with high-grade glioma and ependymoma, supported by a
The company's CNSide CSF assay platform represents a potentially disruptive advancement in CNS metastasis diagnosis. The current standard of care, CSF cytology, offers suboptimal sensitivity, often delaying crucial treatment decisions. CNSide's commercialization strategy, starting in Texas with initial focus on NCI-designated cancer centers, is strategically sound as these institutions treat the highest volume of patients at risk for leptomeningeal metastases. The estimated
The CPRIT grant advance of
Plus Therapeutics shows improved cash position and reduced operating loss, but net income was primarily driven by non-operational accounting adjustments.
Plus Therapeutics' financial position shows some improvement, with cash and investments increasing to
The company's operational metrics show mixed signals. The total operating loss decreased significantly to
However, the reported net income of
The
The upcoming commercialization of the CNSide diagnostic platform, starting in Texas before expanding to other states, represents a potential revenue inflection point. If the company can execute effectively on their diagnostic launch while continuing to advance their therapeutic pipeline, their financial outlook could improve substantially in coming quarters.
Announced CNSide庐 CSF assay platform launch timeline
Initiated the REYOBIQ dose optimization trial for patients with leptomeningeal metastases
HOUSTON, Aug. 14, 2025 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. (Nasdaq: PSTV) (鈥淧lus鈥� or the 鈥淐ompany鈥�), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, today announces financial results for the second quarter ended June 30, 2025, and provides an overview of recent and upcoming business highlights.
鈥淭he second quarter of 2025 marked steady execution and progress on our key strategic initiatives:听 clinical development of our radiotherapeutic and the advancement of our diagnostic platform technologies toward commercialization,鈥� said Marc H. Hedrick, M.D., Plus Therapeutics President and Chief Executive Officer. 鈥淣ew data announcements on our REYOBIQ鈩� CNS cancer radiotherapeutic clinical trials continue to demonstrate favorable safety and efficacy signals, facilitating active enrollment on our dose optimization trial.听 Furthermore, the recently announced launch of the CNSide庐 cerebral spinal fluid (CSF) assay platform and testing services in with initial focus on national cancer centers validates the clinical need for our diagnostic management tool.听 We intend to expand our testing services and broaden the regional availability of CNSide over the next 12 months.鈥�
Q2 2025 & RECENT HIGHLIGHTS AND MILESTONES
Corporate
- Completed a comprehensive restructuring of the March 2025
$15 million equity financing on June 17, 2025, simplifying the Company鈥檚 capital structure - Received notice of an advance payment of
$1.6 million from the Cancer Prevention and Research Institute of Texas (CPRIT), the second-largest public cancer research funder globally, as part of the Company鈥檚 previously awarded$17.6 million grant - Added industry veteran Kyle Guse to the Board of Directors, Mr. Guse brings 30 years of professional experience in multiple executive roles, including Chief Financial Officer, General Counsel, Secretary for some of the world鈥檚 most innovative companies
REYOBIQ鈩� Clinical Trials
- Presented updated interim data on its lead compound REYOBIQ鈩� at the Nuclear Medicine and Neuro-oncology conference highlighting the safety and clinical benefit of REYOBIQ in patients with leptomeningeal metastases (LM)
- Initiated and treated the first two patients in the ReSPECT-LM dose optimization trial for REYOBIQ to evaluate multiple-dose regimens of REYOBIQ administered at defined intervals via intraventricular catheter (Ommaya reservoir) following encouraging results from the Company鈥檚 single-dose escalation trial. 听More information on the trial design can be found
- Received U.S. Food and Drug Administration (FDA) clearance of its Investigational New Drug (IND) application for REYOBIQ for the treatment of pediatric patients with supratentorial recurrent, refractory, or progressive high-grade glioma (HGG) and ependymoma that will be funded by a
$3 million grant from Department of Defense. 听More information can be found - Announced that the Company will give an oral presentation of its ReSPECT-LM clinical trial results titled, 鈥淧hase 1 Dose Escalation of Rhenium (186Re) Obisbemeda (Rhenium Nanoliposome,186RNL (REYOBIQ) for the Treatment of Leptomeningeal Metastases (LM): Clinical Study Results for Safety and Efficacy鈥� (CTSI-06) along with a sponsored educational symposium, at the upcoming SNO/ASCO CNS Metastases Conference on August 14-16, 2025, at the Baltimore Waterfront Marriott Hotel in Baltimore, MD
CNSide CSF Assay Platform
- Hosted a business update wherein details of the anticipated launch of the CNSide cerebral spinal-fluid assay platform were discussed. Highlights include:
- CNS Mets are an epidemic affecting as many as
30% of adult cancer patients and affect the highly protected CNS space; diagnosis and treatment are difficult and as a result, approximately half of patients with CSF metastases instead receive just palliative care or hospice - Current standard of care for CNS Mets diagnosis, CSF cytology, was developed over a century ago and offers suboptimal test sensitivity leading to missed or delayed diagnosis and treatment
- The first test to be commercialized, CNSide CSF Tumor Cell Enumeration (TCE), has a total addressable market estimated to be
$6 billion in the U.S.1 with three additional CNS assays to be added in the coming months - CNSide commercialization to commence in Texas in the third quarter of 2025, followed rapidly by expansion into additional states in late 2025 and 2026
- CNS Mets are an epidemic affecting as many as
- Announced that CNSide will be showcasing two presentations at the upcoming SNO/ASCO CNS Metastases Conference on August 14-16, 2025, at the Baltimore Waterfront Marriott Hotel in Baltimore, MD
- Provided a CNSide Diagnostic launch update, with our CSF assay platform and testing services commercially available in Texas in August 2025. Initial commercial focus will be on National Cancer Institute Designated Cancer Centers, which treat the highest number of patients at risk for leptomeningeal metastases and previously used CNSide
1听The Company has derived this number based on published CNS cancer incidence data, third-party projections of test utilization, and established market benchmarks
Q2 2025 FINANCIAL RESULTS
- The Company鈥檚 cash and investments balance was
$6.9 million at June 30, 2025 compared to$3.6 million at December 31, 2024 - Recognized
$1.4 million in grant revenue in the second quarter of 2025 compared to$1.3 million in the same quarter of 2024, which represents CPRIT鈥檚 share of the costs incurred for our REYOBIQ platform advancement for the treatment of patients with LM - Total operating loss for the second quarter of 2025 was
$1.5 million compared to$3.7 million in the same quarter of 2024 with the decrease primarily attributed to a more heightened focus on operational cost control - Net income for second quarter of 2025 was
$5.2 million , or$0.02 per share, compared to a net loss of$2.9 million , or$(0.45) per share, for the same quarter the prior year; the substantial change is due to$6.5 million of pre-tax income from change in the fair value of derivative instruments
About Plus Therapeutics
Headquartered in Houston, Texas, Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company developing targeted radiotherapeutics for difficult-to-treat cancers of the central nervous system with the potential to enhance clinical outcomes. Combining image-guided local beta radiation and targeted drug delivery approaches, the Company is advancing a pipeline of product candidates with lead programs in LM and recurrent glioblastoma (GBM). The Company has built a supply chain through strategic partnerships that enable the development, manufacturing, and future potential commercialization of its products. For more information, visit .
About REYOBIQ (rhenium 186re obisbemeda)
REYOBIQ (rhenium 186re obisbemeda) is a novel injectable radiotherapy specifically formulated to deliver direct targeted high dose radiation in CNS tumors in a safe, effective, and convenient manner to optimize patient outcomes. REYOBIQ has the potential to reduce off target risks and improve outcomes for CNS cancer patients, versus currently approved therapies, with a more targeted and potent radiation dose. Rhenium-186 is an ideal radioisotope for CNS therapeutic applications due to its short half-life, beta energy for destroying cancerous tissue, and gamma energy for real-time imaging. REYOBIQ is being evaluated for the treatment of recurrent glioblastoma and leptomeningeal metastases in the ReSPECT-GBM and ReSPECT-LM clinical trials. ReSPECT-GBM is supported by an award from the National Cancer Institute (NCI), part of the U.S. National Institutes of Health (NIH), and ReSPECT-LM is funded by a three-year
About CNSide Diagnostic, LLC
CNSide Diagnostics, LLC is a wholly owned subsidiary of Plus Therapeutics, Inc. that develops and commercializes proprietary laboratory-developed tests, such as CNSide, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide CSF Assay Platform enables quantitative analysis and molecular characterization of tumor cells and circulating tumor DNA in the cerebrospinal fluid that inform and improve the management of patients with leptomeningeal metastases. The Company is planning to commercialize CNSide in the U.S. in 2025.
Cautionary Statement Regarding Forward-Looking Statements
This press release contains statements that may be deemed 鈥渇orward-looking statements鈥� within the meaning of U.S. securities laws, including statements regarding clinical trials, expected operations and upcoming developments. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as 鈥渆xpect鈥� 鈥減otential,鈥� 鈥渁nticipating,鈥� 鈥減lanning鈥� and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate.
These statements include, without limitation, statements regarding the potential promise of REYOBIQ, expectations as to the Company鈥檚 future performance, including the next steps in developing the Company鈥檚 product candidates; the Company鈥檚 clinical trials, including statements regarding the timing and characteristics of the ReSPECT-LM single dose and multi-dose clinical trials; the continued evaluation of REYOBIQ鈩� including through evaluations in additional patient cohorts; and expectations regarding receipt of grant funds.
The forward-looking statements included in this press release could differ materially from those expressed or implied by these forward-looking statements because of risks, uncertainties, and other factors that include, but are not limited to, the following: the Company鈥檚 ability to maintain the listing of its common stock on Nasdaq; risks related to a halt in trading or delisting of the Company鈥檚 common stock on Nasdaq; the early stage of the Company鈥檚 product candidates and therapies; the results of the Company鈥檚 research and development activities, including uncertainties relating to the clinical trials of its product candidates and therapies; the Company鈥檚 liquidity and capital resources and its ability to raise additional cash; the outcome of the Company鈥檚 partnering/licensing efforts, risks associated with laws or regulatory requirements applicable to it; market conditions, product performance, litigation or potential litigation, and competition within the cancer diagnostics and therapeutics field; ability to develop and protect proprietary intellectual property or obtain licenses to intellectual property developed by others on commercially reasonable and competitive terms; challenges associated with radiotherapeutic manufacturing, production and distribution capabilities necessary to support the Company鈥檚 clinical trials and any commercial level product demand; and material security breach or cybersecurity attack affecting the Company鈥檚 operations or property. This list of risks, uncertainties, and other factors is not complete. Plus Therapeutics discusses some of these matters more fully, as well as certain risk factors that could affect Plus Therapeutics鈥� business, financial condition, results of operations, and prospects, in its reports filed with the SEC, including Plus Therapeutics鈥� annual report on Form 10-K for the fiscal year ended December 31, 2024, quarterly reports on Form 10-Q, and current reports on Form 8-K. These filings are available for review through the SEC鈥檚 website at www.sec.gov. Any or all forward-looking statements Plus Therapeutics makes may turn out to be wrong and can be affected by inaccurate assumptions Plus Therapeutics might make or by known or unknown risks, uncertainties, and other factors, including those identified in this press release. Accordingly, you should not place undue reliance on the forward-looking statements made in this press release, which speak only as of its date. The Company assumes no responsibility to update or revise any forward-looking statements to reflect events, trends or circumstances after the date they are made unless the Company has an obligation under U.S. federal securities laws to do so.
Investor Contact
CORE IR
[email protected]
| 听 | 听 | |||||||
| PLUS THERAPEUTICS, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) (in thousands, except share and par value data) | 听 | |||||||
| 听 | 听 | |||||||
| 听 | 听 | June听30, 2025 | 听 | 听 | December 31, 2024 | 听 | ||
| Assets | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Current assets: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Cash and cash equivalents | 听 | $ | 2,233 | 听 | 听 | $ | 76 | 听 |
| Investments | 听 | 听 | 4,646 | 听 | 听 | 听 | 3,530 | 听 |
| Grant receivable | 听 | 听 | 1,021 | 听 | 听 | 听 | 571 | 听 |
| Other current assets | 听 | 听 | 1,314 | 听 | 听 | 听 | 1,082 | 听 |
| Total current assets | 听 | 听 | 9,214 | 听 | 听 | 听 | 5,259 | 听 |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Property and equipment, net | 听 | 听 | 289 | 听 | 听 | 听 | 448 | 听 |
| Operating lease right-use-of assets | 听 | 听 | 29 | 听 | 听 | 听 | 73 | 听 |
| Goodwill | 听 | 听 | 372 | 听 | 听 | 听 | 372 | 听 |
| Intangible assets, net | 听 | 听 | 401 | 听 | 听 | 听 | 469 | 听 |
| Other assets | 听 | 听 | 45 | 听 | 听 | 听 | 12 | 听 |
| Total assets | 听 | $ | 10,350 | 听 | 听 | $ | 6,633 | 听 |
| Liabilities and Stockholders鈥� Equity (Deficit) | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Current liabilities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Accounts payable and accrued expenses | 听 | $ | 6,359 | 听 | 听 | $ | 11,288 | 听 |
| Operating lease liability | 听 | 听 | 30 | 听 | 听 | 听 | 44 | 听 |
| Deferred grant liability | 听 | 听 | 927 | 听 | 听 | 听 | 927 | 听 |
| Line of credit | 听 | 听 | 鈥� | 听 | 听 | 听 | 3,292 | 听 |
| Total current liabilities | 听 | 听 | 7,316 | 听 | 听 | 听 | 15,551 | 听 |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Noncurrent operating lease liability | 听 | 听 | 鈥� | 听 | 听 | 听 | 31 | 听 |
| Total liabilities | 听 | 听 | 7,316 | 听 | 听 | 听 | 15,582 | 听 |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Commitments and contingencies (Note 7) | 听 | 听 | 听 | 听 | 听 | 听 | ||
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Stockholders鈥� equity (deficit): | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Preferred stock, | 听 | 听 | 鈥� | 听 | 听 | 听 | 鈥� | 听 |
| Common stock, | 听 | 听 | 92 | 听 | 听 | 听 | 6 | 听 |
| Treasury stock (at cost), 258,425 shares as of June 30, 2025 and December 31, 2024, respectively | 听 | 听 | (500 | ) | 听 | 听 | (500 | ) |
| Additional paid-in capital | 听 | 听 | 509,171 | 听 | 听 | 听 | 485,024 | 听 |
| Accumulated deficit | 听 | 听 | (505,729 | ) | 听 | 听 | (493,479 | ) |
| Total stockholders鈥� equity (deficit) | 听 | 听 | 3,034 | 听 | 听 | 听 | (8,949 | ) |
| Total liabilities and stockholders鈥� equity | 听 | $ | 10,350 | 听 | 听 | $ | 6,633 | 听 |
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| PLUS THERAPEUTICS, INC. CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED) (in thousands, except share and per share data) | 听 | |||||||||||||||
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| 听 | 听 | For the Three Months Ended June 30, | 听 | 听 | For the Six Months Ended June 30, | 听 | ||||||||||
| 听 | 听 | 2025 | 听 | 听 | 2024 | 听 | 听 | 2025 | 听 | 听 | 2024 | 听 | ||||
| Grant revenue | 听 | $ | 1,390 | 听 | 听 | $ | 1,279 | 听 | 听 | $ | 2,449 | 听 | 听 | $ | 2,956 | 听 |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| Operating expenses: | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| Research and development | 听 | 听 | 1,246 | 听 | 听 | 听 | 2,773 | 听 | 听 | 听 | 3,002 | 听 | 听 | 听 | 5,536 | 听 |
| General and administrative | 听 | 听 | 1,682 | 听 | 听 | 听 | 2,203 | 听 | 听 | 听 | 4,521 | 听 | 听 | 听 | 4,416 | 听 |
| Total operating expenses | 听 | 听 | 2,928 | 听 | 听 | 听 | 4,976 | 听 | 听 | 听 | 7,523 | 听 | 听 | 听 | 9,952 | 听 |
| Operating loss | 听 | 听 | (1,538 | ) | 听 | 听 | (3,697 | ) | 听 | 听 | (5,074 | ) | 听 | 听 | (6,996 | ) |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| Other income (expense): | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| Interest income | 听 | 听 | 27 | 听 | 听 | 听 | 67 | 听 | 听 | 听 | 28 | 听 | 听 | 听 | 139 | 听 |
| Interest expense | 听 | 听 | 鈥� | 听 | 听 | 听 | (27 | ) | 听 | 听 | (548 | ) | 听 | 听 | (61 | ) |
| Financing expenses | 听 | 听 | 150 | 听 | 听 | 听 | (3,545 | ) | 听 | 听 | (3,061 | ) | 听 | 听 | (3,545 | ) |
| Warrant issuance costs | 听 | 听 | 鈥� | 听 | 听 | 听 | (432 | ) | 听 | 听 | (964 | ) | 听 | 听 | (432 | ) |
| Change in fair value of derivative instruments | 听 | 听 | 6,512 | 听 | 听 | 听 | 4,694 | 听 | 听 | 听 | (2,631 | ) | 听 | 听 | 4,694 | 听 |
| Total other income (expense) | 听 | 听 | 6,689 | 听 | 听 | 听 | 757 | 听 | 听 | 听 | (7,176 | ) | 听 | 听 | 795 | 听 |
| Net income (loss) | 听 | $ | 5,151 | 听 | 听 | $ | (2,940 | ) | 听 | $ | (12,250 | ) | 听 | $ | (6,201 | ) |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| Per share information | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| Net income (loss) per share of common stock 鈥� basic | 听 | $ | 0.02 | 听 | 听 | $ | (0.45 | ) | 听 | $ | (0.50 | ) | 听 | $ | (1.15 | ) |
| Weighted average number of shares of common stock outstanding 鈥� basic | 听 | 听 | 48,388,862 | 听 | 听 | 听 | 6,500,831 | 听 | 听 | 听 | 24,422,125 | 听 | 听 | 听 | 5,411,382 | 听 |
| Net loss per share of common stock 鈥� diluted | 听 | $ | (0.01 | ) | 听 | $ | (0.71 | ) | 听 | $ | (0.50 | ) | 听 | $ | (1.45 | ) |
| Weighted average number of shares of common stock outstanding 鈥� diluted | 听 | 听 | 209,154,994 | 听 | 听 | 听 | 10,742,924 | 听 | 听 | 听 | 24,422,125 | 听 | 听 | 听 | 7,532,428 | 听 |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||||
| PLUS THERAPEUTICS, INC. CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) (In thousands) | 听 | |||||||
| 听 | 听 | |||||||
| 听 | 听 | For the Six Months Ended June 30, | 听 | |||||
| 听 | 听 | 2025 | 听 | 听 | 2024 | 听 | ||
| Cash flows used in operating activities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Net loss | 听 | $ | (12,250 | ) | 听 | $ | (6,201 | ) |
| Adjustments to reconcile net loss to net cash used in operating activities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Depreciation and amortization | 听 | 听 | 223 | 听 | 听 | 听 | 325 | 听 |
| Amortization of deferred financing costs and debt discount | 听 | 听 | 鈥� | 听 | 听 | 听 | 20 | 听 |
| Share-based compensation expense | 听 | 听 | 300 | 听 | 听 | 听 | 297 | 听 |
| Noncash financing expenses | 听 | 听 | 3,061 | 听 | 听 | 听 | 3,545 | 听 |
| Change in fair value of derivative instruments | 听 | 听 | 2,631 | 听 | 听 | 听 | (4,694 | ) |
| Accretion of discount on short-term investments | 听 | 听 | (22 | ) | 听 | 听 | (23 | ) |
| Reduction in the carrying amount of operating lease right-of-use assets | 听 | 听 | 44 | 听 | 听 | 听 | 63 | 听 |
| Gain on sale of assets | 听 | 听 | (16 | ) | 听 | 听 | 鈥� | 听 |
| Increases (decreases) in cash caused by changes in operating assets and liabilities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Grant receivable | 听 | 听 | (450 | ) | 听 | 听 | 鈥� | 听 |
| Other current assets | 听 | 听 | (265 | ) | 听 | 听 | 335 | 听 |
| Accounts payable and accrued expenses | 听 | 听 | (5,181 | ) | 听 | 听 | 360 | 听 |
| Change in operating lease liabilities | 听 | 听 | (45 | ) | 听 | 听 | (63 | ) |
| Deferred grant liability | 听 | 听 | 鈥� | 听 | 听 | 听 | 373 | 听 |
| Net cash used in operating activities | 听 | 听 | (11,970 | ) | 听 | 听 | (5,663 | ) |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Cash flows used in investing activities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Purchases of property and equipment | 听 | 听 | (10 | ) | 听 | 听 | (121 | ) |
| Purchase of short-term investments | 听 | 听 | (7,756 | ) | 听 | 听 | (3,500 | ) |
| Redemption of short-term investments | 听 | 听 | 6,662 | 听 | 听 | 听 | 鈥� | 听 |
| Purchase of intangible assets | 听 | 听 | 鈥� | 听 | 听 | 听 | (545 | ) |
| Proceeds from sale of property and equipment | 听 | 听 | 30 | 听 | 听 | 听 | 鈥� | 听 |
| Net cash used in investing activities | 听 | 听 | (1,074 | ) | 听 | 听 | (4,166 | ) |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Cash flows provided by financing activities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Principal payments of term loan obligation | 听 | 听 | 鈥� | 听 | 听 | 听 | (3,996 | ) |
| Proceeds from credit facility | 听 | 听 | 鈥� | 听 | 听 | 听 | 3,292 | 听 |
| Repayment of line of credit facility | 听 | 听 | (3,292 | ) | 听 | 听 | 鈥� | 听 |
| Repayment of notes payable | 听 | 听 | (3,703 | ) | 听 | 听 | 鈥� | 听 |
| Issuance of notes payable and warrants | 听 | 听 | 3,738 | 听 | 听 | 听 | 鈥� | 听 |
| Proceeds from exercise of Series B Warrants from May 2024 PIPE | 听 | 听 | 882 | 听 | 听 | 听 | 鈥� | 听 |
| Purchase of treasury stock | 听 | 听 | 鈥� | 听 | 听 | 听 | (374 | ) |
| Proceeds from sale of common stock, pre-funded warrants and warrants | 听 | 听 | 15,001 | 听 | 听 | 听 | 7,310 | 听 |
| Proceeds from sale of common stock under Lincoln Park Purchase Agreement | 听 | 听 | 2,795 | 听 | 听 | 听 | 鈥� | 听 |
| Costs from sale of common stock | 听 | 听 | (220 | ) | 听 | 听 | (45 | ) |
| Net cash provided by financing activities | 听 | 听 | 15,201 | 听 | 听 | 听 | 6,187 | 听 |
| Net increase (decrease) in cash and cash equivalents | 听 | 听 | 2,157 | 听 | 听 | 听 | (3,642 | ) |
| Cash and cash equivalents at beginning of period | 听 | 听 | 76 | 听 | 听 | 听 | 8,554 | 听 |
| Cash and cash equivalents at end of period | 听 | $ | 2,233 | 听 | 听 | $ | 4,912 | 听 |
| 听 | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Supplemental disclosure of cash flows information: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Cash paid during period for: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Interest | 听 | $ | 539 | 听 | 听 | $ | 32 | 听 |
| Supplemental schedule of non-cash investing and financing activities: | 听 | 听 | 听 | 听 | 听 | 听 | ||
| Exchange of warrants for notes payable | 听 | $ | 3,694 | 听 | 听 | $ | 鈥� | 听 |
| Redemption of notes by issuance of common stock, pre-funded warrants and warrants | 听 | $ | 3,512 | 听 | 听 | $ | 鈥� | 听 |
| Unpaid offering cost | 听 | $ | 252 | 听 | 听 | $ | 375 | 听 |
FAQ
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