FMR LLC / Abigail Johnson Report 14.3% Stake in ANNX (15.7M Shares)

Q: What stake in ANNX does FMR LLC report?

FMR LLC reports beneficial ownership of 15,695,226.36 shares , representing 14.3% of Annexon Inc.

Q: Does Abigail P. Johnson hold voting power in ANNX according to the filing?

The filing reports Abigail P. Johnson has 0.00 sole voting power and sole dispositive power of 15,695,226.36 shares .

Q: When is the event date and filing signature date on the Schedule 13G/A?

Date of event requiring the filing is 06/30/2025 and the signature is dated 08/05/2025 .

Q: Are any shared voting or dispositive powers reported?

No; the filing reports shared voting power 0.00 and shared dispositive power 0.00 .

[SCHEDULE 13G/A] Annexon, Inc. SEC Filing

Filing Impact

(Low)

Filing Sentiment

(Neutral)

Form Type

SCHEDULE 13G/A

Rhea-AI Filing Summary

Filing: Schedule 13G/A (Amendment No. 3) reporting beneficial ownership in Annexon Inc. (ANNX) as of 06/30/2025; signature dated 08/05/2025.

Key facts

Reporting persons: FMR LLC and Abigail P. Johnson.
Aggregate beneficial ownership: 15,695,226.36 shares, representing 14.3% of the class.
Voting/dispositive powers reported: FMR LLC sole voting power 15,690,765.00; sole dispositive power 15,695,226.36; shared powers 0.00; Abigail P. Johnson reports sole dispositive power 15,695,226.36; no voting power.

Certification: Signatory certifies the securities are held in the ordinary course of business and not to change or influence control of the issuer. Exhibit 99 and Exhibit 24 references included.

Positive

Material disclosure of ownership: Reporting persons disclose 15,695,226.36 shares (14.3%) beneficial ownership in ANNX.
Clear voting/dispositive breakdown: FMR LLC reports sole voting power 15,690,765 and sole dispositive power 15,695,226.36; shared powers reported as 0.00.
Certification included: Statement that securities are held in the ordinary course of business and not for the purpose of changing or influencing control.

Negative

None.

Insights

TL;DR: FMR LLC and Abigail P. Johnson report a material 14.3% stake in ANNX; disclosure is informational, not an activist signal.

The Schedule 13G/A discloses an aggregate beneficial ownership of 15,695,226.36 shares (14.3%) in Annexon Inc. The cover-page and Item 4 detail sole voting and dispositive powers held by FMR LLC and sole dispositive power reported for Abigail P. Johnson, with all shared powers at 0.00. The filing includes a certification that the holdings are held in the ordinary course of business and not for purposes of changing control. For investors, this is a material ownership disclosure that may affect float and potential investor composition but does not, by itself, indicate governance action.

TL;DR: A >5% institutional stake (14.3%) is material for governance monitoring though the filer disclaims intent to influence control.

The document identifies FMR LLC and Abigail P. Johnson as reporting persons and documents precise voting and dispositive figures, including FMR LLC's sole voting power of 15,690,765 and sole dispositive power of 15,695,226.36. The signature block references a power of attorney and cross-references Exhibit 24 and Exhibit 99. From a governance perspective, the filing requires boards and investors to note an influential shareholder position, while the certification asserts passive intent; further filings or communications would be needed to alter the governance implications.

08/06/2025 - 11:51 AM

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 3)

ANNEXON INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

03589W102

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No.

03589W102

Names of Reporting Persons

FMR LLC

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 15,690,765.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 15,695,226.36
8	Shared Dispositive Power 0.00

Aggregate Amount Beneficially Owned by Each Reporting Person

15,695,226.36

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Percent of class represented by amount in row (9)

14.3 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

03589W102

Names of Reporting Persons

Abigail P. Johnson

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

Sec Use Only

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 15,695,226.36
8	Shared Dispositive Power 0.00

Aggregate Amount Beneficially Owned by Each Reporting Person

15,695,226.36

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Percent of class represented by amount in row (9)

14.3 %

Type of Reporting Person (See Instructions)

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of May 23, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	08/05/2025

Abigail P. Johnson

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of May 23, 2023, by and on behalf of Abigail P. Johnson*
Date:	08/05/2025

Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on August 8, 2023, accession number: 0000315066-23-002397.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.

Source:

FAQ

What stake in ANNX does FMR LLC report?

FMR LLC reports beneficial ownership of 15,695,226.36 shares, representing 14.3% of Annexon Inc.

Does Abigail P. Johnson hold voting power in ANNX according to the filing?

The filing reports Abigail P. Johnson has 0.00 sole voting power and sole dispositive power of 15,695,226.36 shares.

When is the event date and filing signature date on the Schedule 13G/A?

Date of event requiring the filing is 06/30/2025 and the signature is dated 08/05/2025.

Does the filing indicate the holdings are intended to influence control of Annexon?

No; the certification states the securities are held in the ordinary course of business and were not acquired to change or influence control.

Are any shared voting or dispositive powers reported?

No; the filing reports shared voting power 0.00 and shared dispositive power 0.00.

AG真人官方

[SCHEDULE 13G/A] Annexon, Inc. SEC Filing

Insights

FAQ

What stake in ANNX does FMR LLC report?

Does Abigail P. Johnson hold voting power in ANNX according to the filing?

When is the event date and filing signature date on the Schedule 13G/A?

Does the filing indicate the holdings are intended to influence control of Annexon?

Are any shared voting or dispositive powers reported?

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[SCHEDULE 13G/A] Annexon, Inc. SEC Filing

Insights

Securities Analyst neutral

Corporate Governance Expert neutral

FAQ

What stake in ANNX does FMR LLC report?

Does Abigail P. Johnson hold voting power in ANNX according to the filing?

When is the event date and filing signature date on the Schedule 13G/A?

Does the filing indicate the holdings are intended to influence control of Annexon?

Are any shared voting or dispositive powers reported?

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