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[SCHEDULE 13G/A] Ascendis Pharma A/S American SEC Filing

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
SCHEDULE 13G/A
Rhea-AI Filing Summary

Janus Henderson Group plc reported a significant minority holding in Ascendis Pharma A/S American Depositary Shares. The filing shows an aggregate holding of 4,427,792 ADSs, representing 8.0% of the class, with shared voting and shared dispositive power over those shares. The filer is organized in Jersey and lists a UK principal office; the issuer is headquartered in Hellerup, Denmark.

One Janus Henderson subsidiary, JHIUS, may be deemed the beneficial owner of 4,328,772 ADSs (7.8%) with corresponding shared voting and dispositive power. The filing includes a certification that the securities were acquired in the ordinary course of business and not to change or influence control, and attaches a power of attorney authorizing named officers to file required reports.

Janus Henderson Group plc ha segnalato una partecipazione minoritaria significativa nelle American Depositary Shares di Ascendis Pharma A/S. La comunicazione indica un detenuto complessivo di 4,427,792 ADS, pari all'8.0% della classe, con poteri di voto e di disposizione condivisi su tali azioni. Il dichiarante è costituito a Jersey e dichiara un ufficio principale nel Regno Unito; l'emittente ha sede centrale a Hellerup, in Danimarca.

Una controllata di Janus Henderson, JHIUS, potrebbe essere considerata il beneficiario effettivo di 4,328,772 ADS (7.8%) con i corrispondenti poteri di voto e di disposizione condivisi. La comunicazione include una certificazione che i titoli sono stati acquisiti nell'ordinaria attività commerciale e non al fine di modificare o influenzare il controllo, e alleghere una procura che autorizza gli ufficiali indicati a presentare le relazioni richieste.

Janus Henderson Group plc informó una participación minoritaria significativa en American Depositary Shares de Ascendis Pharma A/S. La presentación muestra una tenencia agregada de 4,427,792 ADS, que representa el 8.0% de la clase, con poder de voto y poder dispositvo compartidos sobre esas acciones. El declarante está constituido en Jersey y señala una oficina principal en el Reino Unido; el emisor tiene su sede en Hellerup, Dinamarca.

Una filial de Janus Henderson, JHIUS, podría considerarse la beneficiaria efectiva de 4,328,772 ADS (7.8%) con los correspondientes poderes de voto y de disposición compartidos. La presentación incluye una certificación de que los valores fueron adquiridos en el curso ordinario del negocio y no para cambiar o influir en el control, y adjunta un poder que autoriza a los funcionarios nombrados a presentar los informes requeridos.

Janus Henderson Group plcëŠ� Ascendis Pharma A/Sì� 미국예íƒì¦ì„œ(ADS)ì—� 대í•� ìƒë‹¹í•� 소수 ì§€ë¶„ì„ ì‹ ê³ í–ˆìŠµë‹ˆë‹¤. 제출 서류ëŠ� 해당 í´ëž˜ìŠ¤ì˜ 8.0%ë¥� 차지하는 ì´� 4,427,792 ADS 보유ë¥� 보여주며, 해당 주ì‹ì—� 대í•� ê³µë™ ì˜ê²°ê¶� ë°� ê³µë™ ì²˜ë¶„ê¶Œì„ ë³´ìœ í•˜ê³  있습니다. 제출ì¸ì€ 저지(Jersey)ì—� 설립ë˜ì–´ ì˜êµ­ì� 본사ë¥� 기재했으ë©�, 발행회사ëŠ� ë´ë§ˆí� 헬러ë£�(Hellerup)ì—� 본사ë¥� ë‘ê³  있습니다.

Janus Hendersonì� ìžíšŒì‚� JHIUSëŠ� 4,328,772 ADS(7.8%)ì� 실질ì � 소유ìž�ë¡� 간주ë� ìˆ� 있으ë©�, ì´ì— ìƒì‘하는 ê³µë™ ì˜ê²°ê¶� ë°� ê³µë™ ì²˜ë¶„ê¶Œì„ ê°€ì§‘ë‹ˆë‹�. 제출 서류ì—는 해당 ì¦ê¶Œì� ì •ìƒì ì¸ ì˜ì—… 과정ì—서 ì·¨ë“ë˜ì—ˆìœ¼ë©° 지배권ì� 변경하거나 ì˜í–¥ë ¥ì„ 행사하려ëŠ� 목ì ì� 아님ì� ì¸ì¦í•˜ëŠ” ë‚´ìš©ì� í¬í•¨ë˜ì–´ 있고, ì§€ì •ëœ ìž„ì›ë“¤ì´ í•„ìš”í•� 보고서를 제출í•� ìˆ� 있ë„ë¡� 권한ì� 부여하ëŠ� ìœ„ìž„ìž¥ë„ ì²¨ë¶€ë˜ì–´ 있습니다.

Janus Henderson Group plc a déclaré une participation minoritaire significative dans les American Depositary Shares d'Ascendis Pharma A/S. Le dossier fait état d'une détention globale de 4,427,792 ADS, représentant 8.0% de la catégorie, avec des pouvoirs de vote et de disposition partagés sur ces actions. Le déclarant est constitué à Jersey et indique un bureau principal au Royaume‑Uni ; l'émetteur a son siège à Hellerup, au Danemark.

Une filiale de Janus Henderson, JHIUS, pourrait être considérée comme le propriétaire effectif de 4,328,772 ADS (7.8%) avec les pouvoirs de vote et de disposition partagés correspondants. Le dossier comprend une certification indiquant que les titres ont été acquis dans le cours normal des affaires et non dans le but de modifier ou d'influencer le contrôle, et joint une procuration autorisant les responsables nommés à déposer les rapports requis.

Janus Henderson Group plc meldete eine bedeutende Minderheitsbeteiligung an Ascendis Pharma A/S American Depositary Shares. Die Einreichung weist eine gesamte Beteiligung von 4,427,792 ADS aus, die 8.0% der Klasse darstellen, mit gemeinsamem Stimm- und gemeinsamem Verfügungsrecht über diese Aktien. Der Melder ist in Jersey organisiert und nennt ein Hauptbüro im Vereinigten Königreich; der Emittent hat seinen Hauptsitz in Hellerup, Dänemark.

Eine Tochtergesellschaft von Janus Henderson, JHIUS, kann als wirtschaftlicher Eigentümer von 4,328,772 ADS (7.8%) angesehen werden und verfügt über die entsprechenden gemeinsamen Stimm- und Verfügungsrechte. Die Einreichung enthält eine Bestätigung, dass die Wertpapiere im gewöhnlichen Geschäftsverlauf erworben wurden und nicht zum Zweck der Änderung oder Beeinflussung der Kontrolle, und fügt eine Vollmacht bei, die benannte leitende Angestellte zur Einreichung der erforderlichen Berichte ermächtigt.

Positive
  • Material disclosure of ownership: Aggregate position of 4,427,792 ADSs (8.0%) is clearly reported
  • Transparency on voting and dispositive power: Shared voting and shared dispositive power over reported ADSs is disclosed
  • Compliance documentation included: Certification of ordinary-course acquisition and a power of attorney for filing authority are attached
Negative
  • None.

Insights

TL;DR: Janus Henderson holds a material ~8% stake in Ascendis Pharma, disclosed via Schedule 13G, signaling a sizeable passive position.

The filing documents an aggregate position of 4,427,792 ADSs (8.0%) under Janus Henderson Group plc with shared voting and dispositive power. For one subsidiary (JHIUS) the filing reports 4,328,772 ADSs (7.8%). This is a clear disclosure of a large minority stake above the 5% reporting threshold and is consistent with passive investment activity as certified in the filing. From a portfolio viewpoint, the position is material and requires continued monitoring for changes but the filing itself indicates ordinary-course ownership rather than an active control intent.

TL;DR: The Schedule 13G shows regulatory compliance for a >5% holding, with explicit shared voting/dispositive power and a formal POA for filings.

The report identifies Janus Henderson Group plc as the reporting person, organized in Jersey, and discloses shared voting and dispositive authority over 4,427,792 ADSs (8.0%). It also notes a subsidiary-level beneficial ownership of 4,328,772 ADSs (7.8%). The filing includes a certification that the position is held in the ordinary course and a power of attorney dated December 9, 2022, delegating authority to named officers to execute regulatory reports. These elements demonstrate adherence to disclosure obligations without indicating an intent to influence control.

Janus Henderson Group plc ha segnalato una partecipazione minoritaria significativa nelle American Depositary Shares di Ascendis Pharma A/S. La comunicazione indica un detenuto complessivo di 4,427,792 ADS, pari all'8.0% della classe, con poteri di voto e di disposizione condivisi su tali azioni. Il dichiarante è costituito a Jersey e dichiara un ufficio principale nel Regno Unito; l'emittente ha sede centrale a Hellerup, in Danimarca.

Una controllata di Janus Henderson, JHIUS, potrebbe essere considerata il beneficiario effettivo di 4,328,772 ADS (7.8%) con i corrispondenti poteri di voto e di disposizione condivisi. La comunicazione include una certificazione che i titoli sono stati acquisiti nell'ordinaria attività commerciale e non al fine di modificare o influenzare il controllo, e alleghere una procura che autorizza gli ufficiali indicati a presentare le relazioni richieste.

Janus Henderson Group plc informó una participación minoritaria significativa en American Depositary Shares de Ascendis Pharma A/S. La presentación muestra una tenencia agregada de 4,427,792 ADS, que representa el 8.0% de la clase, con poder de voto y poder dispositvo compartidos sobre esas acciones. El declarante está constituido en Jersey y señala una oficina principal en el Reino Unido; el emisor tiene su sede en Hellerup, Dinamarca.

Una filial de Janus Henderson, JHIUS, podría considerarse la beneficiaria efectiva de 4,328,772 ADS (7.8%) con los correspondientes poderes de voto y de disposición compartidos. La presentación incluye una certificación de que los valores fueron adquiridos en el curso ordinario del negocio y no para cambiar o influir en el control, y adjunta un poder que autoriza a los funcionarios nombrados a presentar los informes requeridos.

Janus Henderson Group plcëŠ� Ascendis Pharma A/Sì� 미국예íƒì¦ì„œ(ADS)ì—� 대í•� ìƒë‹¹í•� 소수 ì§€ë¶„ì„ ì‹ ê³ í–ˆìŠµë‹ˆë‹¤. 제출 서류ëŠ� 해당 í´ëž˜ìŠ¤ì˜ 8.0%ë¥� 차지하는 ì´� 4,427,792 ADS 보유ë¥� 보여주며, 해당 주ì‹ì—� 대í•� ê³µë™ ì˜ê²°ê¶� ë°� ê³µë™ ì²˜ë¶„ê¶Œì„ ë³´ìœ í•˜ê³  있습니다. 제출ì¸ì€ 저지(Jersey)ì—� 설립ë˜ì–´ ì˜êµ­ì� 본사ë¥� 기재했으ë©�, 발행회사ëŠ� ë´ë§ˆí� 헬러ë£�(Hellerup)ì—� 본사ë¥� ë‘ê³  있습니다.

Janus Hendersonì� ìžíšŒì‚� JHIUSëŠ� 4,328,772 ADS(7.8%)ì� 실질ì � 소유ìž�ë¡� 간주ë� ìˆ� 있으ë©�, ì´ì— ìƒì‘하는 ê³µë™ ì˜ê²°ê¶� ë°� ê³µë™ ì²˜ë¶„ê¶Œì„ ê°€ì§‘ë‹ˆë‹�. 제출 서류ì—는 해당 ì¦ê¶Œì� ì •ìƒì ì¸ ì˜ì—… 과정ì—서 ì·¨ë“ë˜ì—ˆìœ¼ë©° 지배권ì� 변경하거나 ì˜í–¥ë ¥ì„ 행사하려ëŠ� 목ì ì� 아님ì� ì¸ì¦í•˜ëŠ” ë‚´ìš©ì� í¬í•¨ë˜ì–´ 있고, ì§€ì •ëœ ìž„ì›ë“¤ì´ í•„ìš”í•� 보고서를 제출í•� ìˆ� 있ë„ë¡� 권한ì� 부여하ëŠ� ìœ„ìž„ìž¥ë„ ì²¨ë¶€ë˜ì–´ 있습니다.

Janus Henderson Group plc a déclaré une participation minoritaire significative dans les American Depositary Shares d'Ascendis Pharma A/S. Le dossier fait état d'une détention globale de 4,427,792 ADS, représentant 8.0% de la catégorie, avec des pouvoirs de vote et de disposition partagés sur ces actions. Le déclarant est constitué à Jersey et indique un bureau principal au Royaume‑Uni ; l'émetteur a son siège à Hellerup, au Danemark.

Une filiale de Janus Henderson, JHIUS, pourrait être considérée comme le propriétaire effectif de 4,328,772 ADS (7.8%) avec les pouvoirs de vote et de disposition partagés correspondants. Le dossier comprend une certification indiquant que les titres ont été acquis dans le cours normal des affaires et non dans le but de modifier ou d'influencer le contrôle, et joint une procuration autorisant les responsables nommés à déposer les rapports requis.

Janus Henderson Group plc meldete eine bedeutende Minderheitsbeteiligung an Ascendis Pharma A/S American Depositary Shares. Die Einreichung weist eine gesamte Beteiligung von 4,427,792 ADS aus, die 8.0% der Klasse darstellen, mit gemeinsamem Stimm- und gemeinsamem Verfügungsrecht über diese Aktien. Der Melder ist in Jersey organisiert und nennt ein Hauptbüro im Vereinigten Königreich; der Emittent hat seinen Hauptsitz in Hellerup, Dänemark.

Eine Tochtergesellschaft von Janus Henderson, JHIUS, kann als wirtschaftlicher Eigentümer von 4,328,772 ADS (7.8%) angesehen werden und verfügt über die entsprechenden gemeinsamen Stimm- und Verfügungsrechte. Die Einreichung enthält eine Bestätigung, dass die Wertpapiere im gewöhnlichen Geschäftsverlauf erworben wurden und nicht zum Zweck der Änderung oder Beeinflussung der Kontrolle, und fügt eine Vollmacht bei, die benannte leitende Angestellte zur Einreichung der erforderlichen Berichte ermächtigt.






Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)






SCHEDULE 13G





SCHEDULE 13G



JANUS HENDERSON GROUP PLC
Signature:Kristin Mariani
Name/Title:Head of North America Compliance, CCO
Date:08/14/2025
Exhibit Information

POWER OF ATTORNEY The undersigned, Janus Henderson Group plc ("the Company"), does hereby make, constitute and appoint each of Kristin Mariani and Caroline Barotti acting severally, as its true and lawful attorneys in-fact, for the purpose of, from time to time, executing in its name and on its behalf, whether the Company individually or as representative of others, any and all documents, certificates, instruments, statements, other filings and amendments to the foregoing (collectively, "documents") determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including, without limitation, Forms 13D, 13F, 13G and 13H and any amendments to any of the foregoing as may be required to be filed with the Securities and Exchange Commission, and delivering, furnishing or filing any such documents with the appropriate governmental, regulatory authority or other person, and giving and granting to each such attorney-in-fact power and authority to act in the premises as fully and to all intents and purposes as the Company might or could do if personally present by one of its authorized signatories, hereby ratifying and confirming all that said attorney-in-fact shall lawfully do or cause to be done by virtue hereof. Any such determination by an attorney-in-fact named herein shall be conclusively evidenced by such person's execution, delivery, furnishing or filing of the applicable document. This power of attorney shall be valid from the date hereof and shall remain in full force and effect until either revoked in writing by the Company, or, in respect of any attorney-in-fact named herein, until such person ceases to be an employee of the Company or one of its affiliates. IN WITNESS WHEREOF, the undersigned has caused this power of attorney to be executed as of this 9th day of December, 2022. Janus Henderson Group plc By: /s/ Michelle Rosenberg Name: Michelle Rosenberg Title: General Counsel and Company Secretary

FAQ

What stake does Janus Henderson report in Ascendis Pharma (ASND)?

The filing reports an aggregate holding of 4,427,792 ADSs, equal to 8.0% of the class held with shared voting and dispositive power.

Does any Janus Henderson subsidiary own Ascendis ADSs separately?

Yes. The filing states that JHIUS may be deemed beneficial owner of 4,328,772 ADSs (7.8%) with shared voting and dispositive power.

What class of Ascendis securities is being reported?

The report covers American Depositary Shares of Ascendis Pharma A/S, CUSIP 04351P101.

Does the filing indicate an intent to influence control of Ascendis Pharma?

No. The filing includes a certification stating the securities were acquired and are held in the ordinary course of business and not to change or influence control.

Who signed the Schedule 13G on behalf of Janus Henderson?

The signature block lists Kristin Mariani, Head of North America Compliance, CCO, as the signing party.

Is there authorization for individuals to file reports for Janus Henderson?

Yes. The filing attaches a power of attorney appointing named officers to execute and file required ownership reports on the Company’s behalf.
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