AG˹ٷ

STOCK TITAN

[Form 4] Castle Biosciences, Inc. Insider Trading Activity

Filing Impact
(Neutral)
Filing Sentiment
(Negative)
Form Type
4
Rhea-AI Filing Summary

Codexis, Inc. (CDXS) received a Form 4 filing from Opaleye Management Inc., a 10% beneficial owner, detailing an open-market purchase completed on 27 June 2025.

  • Transaction: 100,000 shares of Codexis common stock were purchased (Code P) at an average price of $2.39 per share.
  • Post-transaction holdings: Opaleye now reports 12,350,000 shares held indirectly through Opaleye, L.P. and an additional 250,000 shares in a separately managed account, bringing total reported beneficial ownership to 12.6 million shares.
  • Ownership form: All shares are reported as indirect (Form I); the investment manager disclaims beneficial ownership beyond its pecuniary interest.
  • Reporting party status: Opaleye is classified as a 10% owner; no board or executive role is indicated.

The filing signals incremental insider accumulation by a large shareholder. While the 100 k-share purchase is modest relative to the 12.35 million-share position, fresh buying can be interpreted by investors as a vote of confidence in Codexis at current price levels. No derivative transactions, sales or options were disclosed in this filing.

Codexis, Inc. (CDXS) ha ricevuto una comunicazione Form 4 da parte di Opaleye Management Inc., un azionista con una partecipazione del 10%, che dettaglia un acquisto sul mercato aperto effettuato il 27 giugno 2025.

  • Transazione: sono state acquistate (Codice P) 100.000 azioni ordinarie di Codexis a un prezzo medio di 2,39 $ per azione.
  • Detenzione post-transazione: Opaleye dichiara ora di detenere indirettamente 12.350.000 azioni tramite Opaleye, L.P. e ulteriori 250.000 azioni in un conto gestito separatamente, per un totale di 12,6 milioni di azioni di proprietà beneficiaria.
  • Forma di proprietà: Tutte le azioni sono riportate come indirette (Modulo I); il gestore degli investimenti esclude la proprietà beneficiaria oltre il proprio interesse pecuniario.
  • Stato del soggetto segnalante: Opaleye è classificata come un azionista con il 10%; non è indicato alcun ruolo nel consiglio o esecutivo.

La comunicazione indica un accumulo incrementale da parte di un grande azionista interno. Sebbene l'acquisto di 100.000 azioni sia modesto rispetto alla posizione di 12,35 milioni di azioni, l'acquisto può essere interpretato dagli investitori come un segnale di fiducia in Codexis ai livelli di prezzo attuali. Non sono state divulgate transazioni derivati, vendite o opzioni in questa comunicazione.

Codexis, Inc. (CDXS) recibió una presentación Formulario 4 de Opaleye Management Inc., un propietario beneficiario del 10%, detallando una compra en el mercado abierto completada el 27 de junio de 2025.

  • հԲó: se adquirieron 100,000 acciones ordinarias de Codexis (Código P) a un precio promedio de $2.39 por acción.
  • Participación después de la transacción: Opaleye reporta ahora tener 12,350,000 acciones indirectamente a través de Opaleye, L.P. y otras 250,000 acciones en una cuenta gestionada por separado, sumando una propiedad beneficiaria total de 12.6 millones de acciones.
  • Forma de propiedad: Todas las acciones se reportan como indirectas (Formulario I); el gestor de inversiones niega la propiedad beneficiaria más allá de su interés pecuniario.
  • Estado del informante: Opaleye está clasificado como un propietario del 10%; no se indica ningún rol en la junta o ejecutivo.

La presentación indica una acumulación incremental por parte de un gran accionista interno. Aunque la compra de 100,000 acciones es modesta en relación con la posición de 12.35 millones de acciones, la compra puede interpretarse como un voto de confianza en Codexis a los niveles actuales de precio. No se divulgaron transacciones derivadas, ventas u opciones en esta presentación.

Codexis, Inc. (CDXS)� 10% 지분을 보유� Opaleye Management Inc.로부� 2025� 6� 27�� 완료� 공개 시장 매수� 관� Form 4 신고� 받았습니�.

  • 거래 내용: Codexis 보통� 100,000주를 주당 평균 $2.39구매(코드 P)했습니다.
  • 거래 � 보유 현황: 貹� 현재 Opaleye, L.P.� 통해 간접적으� 12,350,000주를 보유하고 있으�, 별도� 관리되� 계좌� 추가� 250,000주를 보유하여 � 1,260�주의 실질 소유권을 보고하고 있습니다.
  • 소유 형태: 모든 주식은 간접 소유(양식 I)� 보고되었으며, 투자 매니저� 금전� 이익� 초과하는 실질 소유권을 부인합니다.
  • 보고� 지�: 貹� 10% 소유�� 분류되며, 이사회나 임원 역할은 명시되지 않았습니�.

이번 신고� 대주주� 의한 점진적인 내부� 매수 신호� 나타냅니�. 10� � 매수� 1,235� � 보유� 비해 소규모이지�, 신규 매수� 투자자들에게 현재 가� 수준에서 Codexis� 대� 신뢰� 표시� 해석� � 있습니다. 이번 신고에는 파생상품 거래, 매도 또는 옵션은 포함되지 않았습니�.

Codexis, Inc. (CDXS) a reçu un dépôt Formulaire 4 de la part de Opaleye Management Inc., un détenteur bénéficiaire de 10%, détaillant un achat sur le marché ouvert réalisé le 27 juin 2025.

  • Transaction : 100 000 actions ordinaires de Codexis ont été achetées (Code P) à un prix moyen de 2,39 $ par action.
  • Détentions après la transaction : Opaleye déclare désormais détenir indirectement 12 350 000 actions via Opaleye, L.P., ainsi que 250 000 actions supplémentaires dans un compte géré séparément, portant la propriété bénéficiaire totale déclarée à 12,6 millions d'actions.
  • Forme de propriété : Toutes les actions sont déclarées comme indirectes (Formulaire I) ; le gestionnaire d'investissement décline toute propriété bénéficiaire au-delà de son intérêt pécuniaire.
  • Statut du déclarant : Opaleye est classé comme un détenteur de 10% ; aucun rôle au conseil d'administration ou exécutif n'est indiqué.

Le dépôt signale une accumulation progressive d'initié par un grand actionnaire. Bien que l'achat de 100 000 actions soit modeste par rapport à la position de 12,35 millions d'actions, ce nouvel achat peut être interprété par les investisseurs comme un vote de confiance en Codexis aux niveaux de prix actuels. Aucune transaction sur dérivés, vente ou option n'a été divulguée dans ce dépôt.

Codexis, Inc. (CDXS) erhielt eine Form 4-Meldung von Opaleye Management Inc., einem 10%igen wirtschaftlichen Eigentümer, die einen am 27. Juni 2025 abgeschlossenen Kauf am offenen Markt beschreibt.

  • Transaktion: 100.000 Aktien der Codexis-Stammaktien wurden zu einem Durchschnittspreis von 2,39 $ pro Aktie gekauft (Code P).
  • Bestand nach der Transaktion: Opaleye meldet nun indirekt 12.350.000 Aktien, gehalten über Opaleye, L.P., sowie weitere 250.000 Aktien in einem separat verwalteten Konto, was eine insgesamt gemeldete wirtschaftliche Beteiligung von 12,6 Millionen Aktien ergibt.
  • Form des Eigentums: Alle Aktien werden als indirekt (Formular I) gemeldet; der Investmentmanager lehnt eine wirtschaftliche Eigentümerschaft über sein geldliches Interesse hinaus ab.
  • Status der meldenden Partei: Opaleye wird als 10% Eigentümer eingestuft; keine Vorstandsfunktion oder leitende Position ist angegeben.

Die Meldung signalisiert eine schrittweise Insider-Akkumulation durch einen Großaktionär. Obwohl der Kauf von 100.000 Aktien im Verhältnis zu der Position von 12,35 Millionen Aktien gering ist, kann das frische Kaufinteresse von Investoren als Vertrauensbeweis in Codexis zu den aktuellen Kursniveaus interpretiert werden. In dieser Meldung wurden keine Derivatgeschäfte, Verkäufe oder Optionen offengelegt.

Positive
  • 10% owner purchased 100,000 shares at $2.39, signalling confidence and raising total indirect stake to 12.35 million shares.
Negative
  • None.

Insights

TL;DR 10% owner Opaleye adds 100 k shares, lifting indirect stake to 12.35 m; modest but positive insider-buy signal.

Analysis: The $2.39 purchase price sits near recent lows, implying the investor views shares as undervalued. Although the incremental buy represents less than 1% of Opaleye’s existing position, continued accumulation by a fund already above the 10% threshold can bolster market sentiment. No sales or hedges were reported, reducing concerns of near-term distribution. Absent earnings data, the purchase is a standalone bullish indicator rather than confirmation of fundamental improvement.

TL;DR Additional indirect insider purchase strengthens alignment but retains disclaimer of true beneficial ownership.

The filing underscores sustained economic exposure by Opaleye without altering governance dynamics—no board seat, no direct control. Indirect holding structure limits transparency, yet repeated open-market buying typically aligns interests with minority shareholders. The absence of derivative grants or preferential terms suggests market-rate acquisition, lowering agency-risk concerns. Overall governance impact: mildly positive.

Codexis, Inc. (CDXS) ha ricevuto una comunicazione Form 4 da parte di Opaleye Management Inc., un azionista con una partecipazione del 10%, che dettaglia un acquisto sul mercato aperto effettuato il 27 giugno 2025.

  • Transazione: sono state acquistate (Codice P) 100.000 azioni ordinarie di Codexis a un prezzo medio di 2,39 $ per azione.
  • Detenzione post-transazione: Opaleye dichiara ora di detenere indirettamente 12.350.000 azioni tramite Opaleye, L.P. e ulteriori 250.000 azioni in un conto gestito separatamente, per un totale di 12,6 milioni di azioni di proprietà beneficiaria.
  • Forma di proprietà: Tutte le azioni sono riportate come indirette (Modulo I); il gestore degli investimenti esclude la proprietà beneficiaria oltre il proprio interesse pecuniario.
  • Stato del soggetto segnalante: Opaleye è classificata come un azionista con il 10%; non è indicato alcun ruolo nel consiglio o esecutivo.

La comunicazione indica un accumulo incrementale da parte di un grande azionista interno. Sebbene l'acquisto di 100.000 azioni sia modesto rispetto alla posizione di 12,35 milioni di azioni, l'acquisto può essere interpretato dagli investitori come un segnale di fiducia in Codexis ai livelli di prezzo attuali. Non sono state divulgate transazioni derivati, vendite o opzioni in questa comunicazione.

Codexis, Inc. (CDXS) recibió una presentación Formulario 4 de Opaleye Management Inc., un propietario beneficiario del 10%, detallando una compra en el mercado abierto completada el 27 de junio de 2025.

  • հԲó: se adquirieron 100,000 acciones ordinarias de Codexis (Código P) a un precio promedio de $2.39 por acción.
  • Participación después de la transacción: Opaleye reporta ahora tener 12,350,000 acciones indirectamente a través de Opaleye, L.P. y otras 250,000 acciones en una cuenta gestionada por separado, sumando una propiedad beneficiaria total de 12.6 millones de acciones.
  • Forma de propiedad: Todas las acciones se reportan como indirectas (Formulario I); el gestor de inversiones niega la propiedad beneficiaria más allá de su interés pecuniario.
  • Estado del informante: Opaleye está clasificado como un propietario del 10%; no se indica ningún rol en la junta o ejecutivo.

La presentación indica una acumulación incremental por parte de un gran accionista interno. Aunque la compra de 100,000 acciones es modesta en relación con la posición de 12.35 millones de acciones, la compra puede interpretarse como un voto de confianza en Codexis a los niveles actuales de precio. No se divulgaron transacciones derivadas, ventas u opciones en esta presentación.

Codexis, Inc. (CDXS)� 10% 지분을 보유� Opaleye Management Inc.로부� 2025� 6� 27�� 완료� 공개 시장 매수� 관� Form 4 신고� 받았습니�.

  • 거래 내용: Codexis 보통� 100,000주를 주당 평균 $2.39구매(코드 P)했습니다.
  • 거래 � 보유 현황: 貹� 현재 Opaleye, L.P.� 통해 간접적으� 12,350,000주를 보유하고 있으�, 별도� 관리되� 계좌� 추가� 250,000주를 보유하여 � 1,260�주의 실질 소유권을 보고하고 있습니다.
  • 소유 형태: 모든 주식은 간접 소유(양식 I)� 보고되었으며, 투자 매니저� 금전� 이익� 초과하는 실질 소유권을 부인합니다.
  • 보고� 지�: 貹� 10% 소유�� 분류되며, 이사회나 임원 역할은 명시되지 않았습니�.

이번 신고� 대주주� 의한 점진적인 내부� 매수 신호� 나타냅니�. 10� � 매수� 1,235� � 보유� 비해 소규모이지�, 신규 매수� 투자자들에게 현재 가� 수준에서 Codexis� 대� 신뢰� 표시� 해석� � 있습니다. 이번 신고에는 파생상품 거래, 매도 또는 옵션은 포함되지 않았습니�.

Codexis, Inc. (CDXS) a reçu un dépôt Formulaire 4 de la part de Opaleye Management Inc., un détenteur bénéficiaire de 10%, détaillant un achat sur le marché ouvert réalisé le 27 juin 2025.

  • Transaction : 100 000 actions ordinaires de Codexis ont été achetées (Code P) à un prix moyen de 2,39 $ par action.
  • Détentions après la transaction : Opaleye déclare désormais détenir indirectement 12 350 000 actions via Opaleye, L.P., ainsi que 250 000 actions supplémentaires dans un compte géré séparément, portant la propriété bénéficiaire totale déclarée à 12,6 millions d'actions.
  • Forme de propriété : Toutes les actions sont déclarées comme indirectes (Formulaire I) ; le gestionnaire d'investissement décline toute propriété bénéficiaire au-delà de son intérêt pécuniaire.
  • Statut du déclarant : Opaleye est classé comme un détenteur de 10% ; aucun rôle au conseil d'administration ou exécutif n'est indiqué.

Le dépôt signale une accumulation progressive d'initié par un grand actionnaire. Bien que l'achat de 100 000 actions soit modeste par rapport à la position de 12,35 millions d'actions, ce nouvel achat peut être interprété par les investisseurs comme un vote de confiance en Codexis aux niveaux de prix actuels. Aucune transaction sur dérivés, vente ou option n'a été divulguée dans ce dépôt.

Codexis, Inc. (CDXS) erhielt eine Form 4-Meldung von Opaleye Management Inc., einem 10%igen wirtschaftlichen Eigentümer, die einen am 27. Juni 2025 abgeschlossenen Kauf am offenen Markt beschreibt.

  • Transaktion: 100.000 Aktien der Codexis-Stammaktien wurden zu einem Durchschnittspreis von 2,39 $ pro Aktie gekauft (Code P).
  • Bestand nach der Transaktion: Opaleye meldet nun indirekt 12.350.000 Aktien, gehalten über Opaleye, L.P., sowie weitere 250.000 Aktien in einem separat verwalteten Konto, was eine insgesamt gemeldete wirtschaftliche Beteiligung von 12,6 Millionen Aktien ergibt.
  • Form des Eigentums: Alle Aktien werden als indirekt (Formular I) gemeldet; der Investmentmanager lehnt eine wirtschaftliche Eigentümerschaft über sein geldliches Interesse hinaus ab.
  • Status der meldenden Partei: Opaleye wird als 10% Eigentümer eingestuft; keine Vorstandsfunktion oder leitende Position ist angegeben.

Die Meldung signalisiert eine schrittweise Insider-Akkumulation durch einen Großaktionär. Obwohl der Kauf von 100.000 Aktien im Verhältnis zu der Position von 12,35 Millionen Aktien gering ist, kann das frische Kaufinteresse von Investoren als Vertrauensbeweis in Codexis zu den aktuellen Kursniveaus interpretiert werden. In dieser Meldung wurden keine Derivatgeschäfte, Verkäufe oder Optionen offengelegt.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
MAETZOLD DEREK J

(Last) (First) (Middle)
C/O CASTLE BIOSCIENCES, INC.
505 S. FRIENDSWOOD DRIVE, SUITE 401

(Street)
FRIENDSWOOD TX 77546

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
CASTLE BIOSCIENCES INC [ CSTL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
X Officer (give title below) Other (specify below)
Pres. & Chief Exec. Officer
3. Date of Earliest Transaction (Month/Day/Year)
06/27/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/27/2025 S(1) 4,944 D $20.3(2) 69,683 D
Common Stock 06/27/2025 S(1) 8,068 D $20.3(2) 52,923 I By The Maetzold Descendants 2020 Trust(3)
Common Stock 06/27/2025 S(1) 6,924 D $20.3(2) 44,986 I By Derek Maetzold 2020 Irrevocable Trust(4)
Common Stock 06/27/2025 S(1) 660 D $20.3(2) 3,618 I By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk(5)
Common Stock 06/27/2025 S(1) 660 D $20.3(2) 3,615 I By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold(6)
Common Stock 06/27/2025 S(1) 660 D $20.3(2) 3,615 I By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold(7)
Common Stock 06/27/2025 S(1) 660 D $20.3(2) 3,615 I By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold(8)
Common Stock 122,866 I By DJM Grantor Retained Annuity Trust No. 5(9)
Common Stock 26,134 I By DJM Grantor Retained Annuity Trust No. 6(10)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person, The Maetzold Descendants 2020 Trust, Derek Maetzold 2020 Irrevocable Trust, The Maetzold 2018 Remainder Trust f/b/o Emily Carol Kirk, The Maetzold 2018 Remainder Trust f/b/o Hannah Elizabeth Maetzold, The Maetzold 2018 Remainder Trust f/b/o John Derek Maetzold, and The Maetzold 2018 Remainder Trust f/b/o Peter Douglas Maetzold on November 11, 2024.
2. This transaction was executed in multiple trades at prices ranging from $20.00 to $20.51, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
3. Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries.
4. Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries.
5. Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary.
6. Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
7. Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
8. Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
9. Held by DJM Grantor Retained Annuity Trust No. 5 of which the Reporting Person is the trustee and beneficiary.
10. Held by DJM Grantor Retained Annuity Trust No. 6 of which the Reporting Person is the trustee and the beneficiaries are The Maetzold 2018 Remainder Trust FBO John Derek Maetzold, The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk, The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold and The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold.
Remarks:
/s/ Frank Stokes, Attorney-in-fact 07/01/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many Codexis (CDXS) shares did Opaleye buy on 27 June 2025?

100,000 shares of common stock were purchased.

What was the purchase price for the insider transaction in CDXS?

The shares were acquired at $2.39 per share.

What is Opaleye’s total reported ownership in Codexis after the transaction?

Opaleye reports 12,350,000 shares via Opaleye, L.P. plus 250,000 in a managed account.

Did the Form 4 include any stock sales or derivative transactions?

No. The filing discloses only a purchase of common stock and reports no derivatives or sales.

Why is Opaleye considered a 10% owner of Codexis?

Its aggregated indirect holdings exceed 10% of Codexis� outstanding common stock, triggering Section 16 reporting.
Castle Biosciences

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Diagnostics & Research
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United States
FRIENDSWOOD