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Aaron Freidin, Chief Financial Officer and Director of GRAIL, Inc. (GRAL), reported a sale of 877 shares of GRAIL common stock on 08/19/2025 at a weighted-average price of $32.02 per share. After the reported transactions, he beneficially owns 285,143 shares, held directly. The filing states the sale was executed as a block trade in multiple transactions and that the broker-calculated price is a weighted average; the reporter offers to provide detailed per-trade pricing on request. No derivative transactions were reported.

Form 144 notice for GRAIL, Inc. (GRAL) states that an individual plans to sell 4,511 shares of the issuer's common stock on the NASDAQ with an aggregate market value of $147,964.08, against 36,047,799 shares outstanding. The securities were acquired on 06/28/2024 when 8,076 shares vested from restricted stock units issued by the company; payment was recorded as services rendered. The filer discloses two recent sales by the same person in the past three months: 9,692 shares sold on 06/12/2025 for $410,019.09 and 6,992 shares sold on 06/30/2025 for $503,984. The form includes the required representation that the seller is not aware of undisclosed material adverse information.

GRAIL, Inc. Form 144 discloses a proposed sale under Rule 144 of 952 shares of common stock by the named person, with an aggregate market value of $30,873.36, and an approximate sale date of 08/21/2025 on the NASDAQ. The shares were acquired upon vesting of restricted stock units on 06/28/2024 and were granted as compensation for services. The filing also reports a prior sale by Aaron Freidin of 8,000 shares on 07/15/2025 generating gross proceeds of $311,440. The filer affirms no undisclosed material adverse information is known.

This Schedule 13G/A reports that PRIMECAP MANAGEMENT CO/CA beneficially owns 2,057,089 shares of GRAIL common stock (class reported as COM), representing 5.72% of the outstanding class. The filing discloses sole voting power over 2,027,466 shares and sole dispositive power over 2,057,089 shares.

The statement affirms the securities are held in the ordinary course of business and were not acquired to change or influence control of the issuer. Items identifying group members, subsidiaries and related classifications are marked not applicable, and the filing includes the certification required under Item 10 attesting to the accuracy of the disclosure.

GRAIL, Inc. (GRAL) reported Q2 2025 results showing revenue growth and materially smaller operating losses versus prior-year periods after large pushdown impairments in 2024. Total revenue was $35.5 million for the quarter and $67.4 million for the six months, driven mainly by screening revenue. Net loss was $114.0 million for the quarter and $220.2 million for six months, versus multi鈥慼undred鈥憁illion and billion鈥憀evel losses in 2024 primarily from goodwill and IPR&D impairments. The balance sheet shows $130.8 million of cash and restricted cash and $475.3 million of short鈥憈erm marketable securities; management believes these resources are sufficient to fund operations for at least 12 months. The company completed its Spin鈥慜ff from Illumina, received $932.3 million of disposal funding subject to a time鈥憀imited clawback, and disclosed positive registrational trial signals (NHS鈥慓alleri prevalent round and initial PATHFINDER 2 top鈥憀ine results). Significant amortization and prior impairment charges continue to affect reported operating results and accumulated deficit.

GRAIL, Inc. furnished a press release reporting its financial results for the second quarter ended June 30, 2025; the press release is attached as Exhibit 99.1 to this current report. The 8-K text states the press release announces second-quarter financial results but does not include the underlying financial tables or metrics within the filing itself.

The exhibit is furnished, not filed, so the press release is not automatically incorporated by reference into other SEC filings unless explicitly stated. The report also identifies the companyas an emerging growth company and confirms its common stock (par value $0.001) trades under the symbol GRAL on the Nasdaq Global Select Market. Readers must consult Exhibit 99.1 for the full financial figures and management commentary.