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STOCK TITAN

[Form 4] Karyopharm Therapeutics Inc. Insider Trading Activity

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
4
Rhea-AI Filing Summary

Serve Robotics Inc. (SERV) � Form 4 insider transaction

Chief Financial Officer Brian Read disclosed the sale of 1,212 SERV common shares on 30-Jul-2025 at a weighted-average price of $10.457. The shares were sold solely to cover federal and state tax-withholding obligations triggered by the vesting and settlement of restricted stock units (RSUs), as noted in Footnote 1. After the transaction, Read directly owns 396,266 shares.

No derivative securities were bought or sold, and the filing shows no 10b5-1 plan or other pre-arranged trading program. The disposition equals roughly 0.3 % of the executive’s reported holdings, suggesting the officer retains the vast majority of his equity exposure. The document contains no financial metrics, operational updates, or strategic commentary beyond the routine administrative sale.

Serve Robotics Inc. (SERV) � Transazione insider Form 4

Il Chief Financial Officer Brian Read ha comunicato la vendita di 1.212 azioni ordinarie SERV il 30-lug-2025 a un prezzo medio ponderato di 10,457 $. Le azioni sono state vendute esclusivamente per coprire le obbligazioni fiscali federali e statali derivanti dal vesting e dal regolamento delle restricted stock units (RSU), come indicato nella Nota 1. Dopo la transazione, Read detiene direttamente 396.266 azioni.

Non sono stati acquistati o venduti titoli derivati, e il documento non segnala alcun piano 10b5-1 o altro programma di trading predefinito. La vendita rappresenta circa il 0,3% delle partecipazioni dichiarate dell’esecutivo, indicando che l’ufficiale mantiene la stragrande maggioranza della sua esposizione azionaria. Il documento non contiene metriche finanziarie, aggiornamenti operativi o commenti strategici oltre alla normale vendita amministrativa.

Serve Robotics Inc. (SERV) � Transacción insider Formulario 4

El Director Financiero Brian Read reveló la venta de 1,212 acciones ordinarias de SERV el 30-jul-2025 a un precio promedio ponderado de $10.457. Las acciones se vendieron únicamente para cubrir obligaciones fiscales federales y estatales derivadas del vesting y liquidación de unidades de acciones restringidas (RSU), como se indica en la Nota 1. Tras la transacción, Read posee directamente 396,266 acciones.

No se compraron ni vendieron valores derivados, y el documento no muestra ningún plan 10b5-1 ni otro programa de negociación preestablecido. La disposición representa aproximadamente el 0.3% de las participaciones reportadas por el ejecutivo, sugiriendo que el funcionario conserva la gran mayoría de su exposición accionaria. El documento no contiene métricas financieras, actualizaciones operativas ni comentarios estratégicos más allá de la venta administrativa rutinaria.

Serve Robotics Inc. (SERV) � Form 4 내부� 거래

최고재무책임� Brian Read가 2025� 7� 30�1,212� SERV 보통�� 가중평� 가� $10.457� 매도했다� 공시했습니다. � 주식들은 제한 주식 단위(RSU)� 취득 � 정산으로 발생� 연방 � � 세금 원천징수 의무� 충당하기 위해서만 매도되었다고 1� 각주� 명시되어 있습니다. 거래 � Read� 직접 396,266�� 보유하고 있습니다.

파생 증권� 매매� 없었으며, 10b5-1 계획이나 기타 사전 거래 프로그램� 보고되지 않았습니�. 이번 매도� 경영진이 보고� 보유 지분의 � 0.3%� 해당하며, 임원은 대부분의 지� 노출� 유지하고 있음� 시사합니�. 문서에는 재무 지�, 운영 업데이트 또는 전략� 논평� 포함되어 있지 않으�, 단지 일상적인 행정� 매도� 관� 내용입니�.

Serve Robotics Inc. (SERV) � Transaction d’initié Formulaire 4

Le directeur financier Brian Read a déclaré la vente de 1 212 actions ordinaires SERV le 30 juillet 2025 à un prix moyen pondéré de 10,457 $. Les actions ont été vendues uniquement pour couvrir les obligations fiscales fédérales et étatiques liées à l’acquisition et au règlement des unités d’actions restreintes (RSU), comme indiqué en note 1. Après la transaction, Read détient directement 396 266 actions.

Aucun titre dérivé n’a été acheté ou vendu, et le dépôt ne mentionne aucun plan 10b5-1 ni autre programme de trading préétabli. La cession représente environ 0,3 % des participations déclarées de l’exécutif, ce qui suggère que le dirigeant conserve la grande majorité de son exposition en actions. Le document ne contient aucune donnée financière, mise à jour opérationnelle ou commentaire stratégique au-delà de la vente administrative habituelle.

Serve Robotics Inc. (SERV) � Insider-Transaktion Form 4

Finanzvorstand Brian Read meldete den Verkauf von 1.212 SERV-Stammaktien am 30. Juli 2025 zu einem gewichteten Durchschnittspreis von 10,457 $. Die Aktien wurden ausschließlich verkauft, um die bundes- und landesstaatlichen Steuerabzugspflichten zu erfüllen, die durch die Zuteilung und Abwicklung von Restricted Stock Units (RSUs) ausgelöst wurden, wie in Fußnote 1 vermerkt. Nach der Transaktion besitzt Read direkt 396.266 Aktien.

Es wurden keine Derivate gekauft oder verkauft, und die Meldung zeigt keinen 10b5-1-Plan oder ein anderes vorab vereinbartes Handelsprogramm. Die Veräußerung entspricht etwa 0,3 % der gemeldeten Beteiligungen des Geschäftsführers, was darauf hindeutet, dass der Manager den Großteil seiner Aktienexponierung behält. Das Dokument enthält keine finanziellen Kennzahlen, operative Updates oder strategische Kommentare über den routinemäßigen administrativen Verkauf hinaus.

Positive
  • CFO retains 396,266 shares, signaling continued alignment with shareholder interests despite minor sale.
  • Sale was administrative for tax-withholding, reducing concern about negative insider sentiment.
Negative
  • Insider disposition, albeit small, can be perceived negatively by some investors monitoring executive selling activity.

Insights

TL;DR: Routine tax-withholding sale; immaterial impact on insider’s stake or investment thesis.

The CFO sold only 1,212 shares to satisfy RSU tax obligations, leaving him with almost 400k shares. The sale is tiny relative to both his holdings and SERV’s float, indicating no change in insider sentiment. Because the transaction is non-discretionary and disclosure is timely, I view it as compliance-related and not a bearish signal. I rate the filing as neutral for share-price outlook.

TL;DR: Filing shows standard Section 16 compliance; no governance red flags.

Serve Robotics� use of Form 4 for a small RSU-related sale demonstrates proper reporting discipline. The footnotes clarify pricing range and affirm willingness to provide trade detail—good transparency practice. Absence of a 10b5-1 plan notation is acceptable given the ministerial nature of the sale. Overall governance implications are neutral.

Serve Robotics Inc. (SERV) � Transazione insider Form 4

Il Chief Financial Officer Brian Read ha comunicato la vendita di 1.212 azioni ordinarie SERV il 30-lug-2025 a un prezzo medio ponderato di 10,457 $. Le azioni sono state vendute esclusivamente per coprire le obbligazioni fiscali federali e statali derivanti dal vesting e dal regolamento delle restricted stock units (RSU), come indicato nella Nota 1. Dopo la transazione, Read detiene direttamente 396.266 azioni.

Non sono stati acquistati o venduti titoli derivati, e il documento non segnala alcun piano 10b5-1 o altro programma di trading predefinito. La vendita rappresenta circa il 0,3% delle partecipazioni dichiarate dell’esecutivo, indicando che l’ufficiale mantiene la stragrande maggioranza della sua esposizione azionaria. Il documento non contiene metriche finanziarie, aggiornamenti operativi o commenti strategici oltre alla normale vendita amministrativa.

Serve Robotics Inc. (SERV) � Transacción insider Formulario 4

El Director Financiero Brian Read reveló la venta de 1,212 acciones ordinarias de SERV el 30-jul-2025 a un precio promedio ponderado de $10.457. Las acciones se vendieron únicamente para cubrir obligaciones fiscales federales y estatales derivadas del vesting y liquidación de unidades de acciones restringidas (RSU), como se indica en la Nota 1. Tras la transacción, Read posee directamente 396,266 acciones.

No se compraron ni vendieron valores derivados, y el documento no muestra ningún plan 10b5-1 ni otro programa de negociación preestablecido. La disposición representa aproximadamente el 0.3% de las participaciones reportadas por el ejecutivo, sugiriendo que el funcionario conserva la gran mayoría de su exposición accionaria. El documento no contiene métricas financieras, actualizaciones operativas ni comentarios estratégicos más allá de la venta administrativa rutinaria.

Serve Robotics Inc. (SERV) � Form 4 내부� 거래

최고재무책임� Brian Read가 2025� 7� 30�1,212� SERV 보통�� 가중평� 가� $10.457� 매도했다� 공시했습니다. � 주식들은 제한 주식 단위(RSU)� 취득 � 정산으로 발생� 연방 � � 세금 원천징수 의무� 충당하기 위해서만 매도되었다고 1� 각주� 명시되어 있습니다. 거래 � Read� 직접 396,266�� 보유하고 있습니다.

파생 증권� 매매� 없었으며, 10b5-1 계획이나 기타 사전 거래 프로그램� 보고되지 않았습니�. 이번 매도� 경영진이 보고� 보유 지분의 � 0.3%� 해당하며, 임원은 대부분의 지� 노출� 유지하고 있음� 시사합니�. 문서에는 재무 지�, 운영 업데이트 또는 전략� 논평� 포함되어 있지 않으�, 단지 일상적인 행정� 매도� 관� 내용입니�.

Serve Robotics Inc. (SERV) � Transaction d’initié Formulaire 4

Le directeur financier Brian Read a déclaré la vente de 1 212 actions ordinaires SERV le 30 juillet 2025 à un prix moyen pondéré de 10,457 $. Les actions ont été vendues uniquement pour couvrir les obligations fiscales fédérales et étatiques liées à l’acquisition et au règlement des unités d’actions restreintes (RSU), comme indiqué en note 1. Après la transaction, Read détient directement 396 266 actions.

Aucun titre dérivé n’a été acheté ou vendu, et le dépôt ne mentionne aucun plan 10b5-1 ni autre programme de trading préétabli. La cession représente environ 0,3 % des participations déclarées de l’exécutif, ce qui suggère que le dirigeant conserve la grande majorité de son exposition en actions. Le document ne contient aucune donnée financière, mise à jour opérationnelle ou commentaire stratégique au-delà de la vente administrative habituelle.

Serve Robotics Inc. (SERV) � Insider-Transaktion Form 4

Finanzvorstand Brian Read meldete den Verkauf von 1.212 SERV-Stammaktien am 30. Juli 2025 zu einem gewichteten Durchschnittspreis von 10,457 $. Die Aktien wurden ausschließlich verkauft, um die bundes- und landesstaatlichen Steuerabzugspflichten zu erfüllen, die durch die Zuteilung und Abwicklung von Restricted Stock Units (RSUs) ausgelöst wurden, wie in Fußnote 1 vermerkt. Nach der Transaktion besitzt Read direkt 396.266 Aktien.

Es wurden keine Derivate gekauft oder verkauft, und die Meldung zeigt keinen 10b5-1-Plan oder ein anderes vorab vereinbartes Handelsprogramm. Die Veräußerung entspricht etwa 0,3 % der gemeldeten Beteiligungen des Geschäftsführers, was darauf hindeutet, dass der Manager den Großteil seiner Aktienexponierung behält. Das Dokument enthält keine finanziellen Kennzahlen, operative Updates oder strategische Kommentare über den routinemäßigen administrativen Verkauf hinaus.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Poulton Stuart

(Last) (First) (Middle)
C/O KARYOPHARM THERAPEUTICS INC.
85 WELLS AVENUE

(Street)
NEWTON MA 02459

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Karyopharm Therapeutics Inc. [ KPTI ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
EVP, Chief Development Officer
3. Date of Earliest Transaction (Month/Day/Year)
07/29/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 07/29/2025 S(1) 191 D $4.37 27,223 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on May 18, 2022, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person.
/s/ Nancy Smith as Attorney-in-Fact for Stuart Poulton 07/30/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many SERV shares did CFO Brian Read sell?

He sold 1,212 common shares on 30-Jul-2025.

What was the sale price of the SERV shares?

The weighted-average price was $10.457, with trades ranging from $10.45 to $10.47.

Why were the shares sold by the CFO of Serve Robotics?

They were sold to cover tax-withholding obligations associated with vested RSUs.

How many SERV shares does the CFO own after the sale?

Brian Read now directly owns 396,266 shares of Serve Robotics.

Does the Form 4 mention any 10b5-1 trading plan?

No. The filing does not reference a 10b5-1 plan; the sale is classified as routine tax-withholding.
Karyopharm Therapeutics Inc

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Biotechnology
Pharmaceutical Preparations
United States
NEWTON