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[SCHEDULE 13G/A] Lexeo Therapeutics, Inc. SEC Filing

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
SCHEDULE 13G/A
Rhea-AI Filing Summary

Janus Henderson Group plc disclosed a significant passive position in Lexeo Therapeutics, reporting beneficial ownership of 3,684,383 shares, representing 11.1% of the company's common stock. The filing shows shared voting and dispositive power over these shares rather than sole control, and the filer certifies the holdings are held in the ordinary course of business and not to change or influence control.

Separately, Janus Henderson Biotech Innovation Master Fund Ltd is reported to beneficially own 2,041,481 shares (about 6.2%) with shared voting and dispositive power. The filing includes a power of attorney authorizing Janus Henderson personnel to make required regulatory filings on behalf of the group.

Janus Henderson Group plc ha reso nota una rilevante posizione passiva in Lexeo Therapeutics, dichiarando la titolarità effettiva di 3.684.383 azioni, pari al 11,1% del capitale ordinario della società. La comunicazione precisa che sulle azioni sussiste una potestà di voto e dispositiva condivisa, non il controllo esclusivo, e il dichiarante attesta che le partecipazioni sono detenute nell'ordinario esercizio dell'attività e non con l'intento di modificare o influenzare il controllo.

Separatamente, Janus Henderson Biotech Innovation Master Fund Ltd risulta essere titolare effettivo di 2.041.481 azioni (circa il 6,2%) con analoga potestà di voto e dispositiva condivisa. La comunicazione include inoltre una procura che autorizza il personale di Janus Henderson a presentare le necessarie comunicazioni regolamentari per conto del gruppo.

Janus Henderson Group plc declaró una posición pasiva significativa en Lexeo Therapeutics, informando la propiedad beneficiaria de 3.684.383 acciones, que representan el 11,1% del capital social ordinario. La presentación señala que existe poder de voto y dispositvo compartido sobre dichas acciones en lugar de control exclusivo, y el declarante certifica que las participaciones se mantienen en el curso ordinario de negocios y no con la finalidad de cambiar o influir en el control.

Por separado, Janus Henderson Biotech Innovation Master Fund Ltd figura como titular beneficiario de 2.041.481 acciones (aproximadamente el 6,2%) con poder de voto y dispositivo compartido. La presentación incluye además un poder que autoriza al personal de Janus Henderson a realizar las presentaciones reglamentarias requeridas en nombre del grupo.

Janus Henderson Group plc� Lexeo Therapeutics� 대� 중요� 수동� 지분을 공시하며, 회사 보통� � 3,684,383�� 실질 보유하고 있어 전체� 11.1%� 해당한다� 보고했습니다. 제출 문서에는 해당 주식� 대� 단독 통제가 아니� 공동 의결� � 처분�� 있음� 명시하고 있으�, 보유 물량� 영업� 통상� 범위에서 보유되고 있으� 지배권� 변경하거나 영향� 주려� 목적� 아님� 신고인이 증명하고 있습니다.

별도�, Janus Henderson Biotech Innovation Master Fund Ltd� � 6.2%� 해당하는 2,041,481�� 실질 보유� 것으� 보고되었으며 마찬가지� 공동 의결� � 처분권을 보유하고 있습니다. 제출 문서에는 그룹� 대신해 필요� 규제 신고� � � 있도� Janus Henderson 직원들에� 위임장을 부여한 내용� 포함되어 있습니다.

Janus Henderson Group plc a déclaré une position passive significative dans Lexeo Therapeutics, signalant la propriété bénéficiaire de 3 684 383 actions, représentant 11,1% du capital social ordinaire. Le dépôt indique qu'il existe un pouvoir de vote et de disposition partagé sur ces actions plutôt qu'un contrôle exclusif, et le déclarant certifie que les détentions sont maintenues dans le cours normal des affaires et n'ont pas pour but de modifier ou d'influencer le contrôle.

é貹éԳ, Janus Henderson Biotech Innovation Master Fund Ltd détiendrait effectivement 2 041 481 actions (environ 6,2%) avec un même pouvoir de vote et de disposition partagé. Le dossier comprend également une procuration autorisant le personnel de Janus Henderson à effectuer les déclarations réglementaires requises au nom du groupe.

Janus Henderson Group plc hat eine bedeutende passive Beteiligung an Lexeo Therapeutics gemeldet und gibt den wirtschaftlichen Besitz von 3.684.383 Aktien an, was 11,1% des Stammkapitals entspricht. Die Meldung weist darauf hin, dass über diese Aktien gemeinsame Stimm- und Verfügungsbefugnisse bestehen und kein alleiniger Kontrollanspruch vorliegt; der Meldende bestätigt, dass die Bestände im gewöhnlichen Geschäftsverkehr gehalten werden und nicht dazu dienen, die Kontrolle zu ändern oder zu beeinflussen.

Separat wird angegeben, dass Janus Henderson Biotech Innovation Master Fund Ltd wirtschaftlich 2.041.481 Aktien (etwa 6,2%) hält, ebenfalls mit gemeinsamer Stimm- und Verfügungsbefugnis. Die Meldung enthält zudem eine Vollmacht, die Janus Henderson-Mitarbeiter zur Abgabe der erforderlichen regulatorischen Meldungen im Namen der Gruppe ermächtigt.

Positive
  • Material institutional ownership disclosed: Janus Henderson Group reports 3,684,383 shares (11.1%) beneficial ownership, signaling credible investor interest.
  • Affiliated fund holds >5%: Janus Henderson Biotech Innovation Master Fund Ltd holds 2,041,481 shares (6.2%), indicating multiple related entities have meaningful stakes.
Negative
  • None.

Insights

TL;DR: Institutional investor disclosed a material, passive >10% stake; no stated intent to influence control.

The Schedule 13G filing documents that Janus Henderson Group plc holds 3,684,383 shares (11.1%) of LXEO with shared voting and dispositive power, while an affiliated fund holds 2,041,481 shares (6.2%). Because the filing is a 13G and includes a certification that the position is held in the ordinary course of business, the holder characterizes the stake as passive rather than activist. For investors, the disclosure signals meaningful institutional ownership that may increase monitoring and engagement, but it does not, on its face, indicate an intent to change company control.

TL;DR: Material ownership disclosed with shared powers; governance influence appears limited per filing language.

The report shows shared voting and dispositive authority rather than sole control, and the filer explicitly states the securities are not held to influence control. The inclusion of a power of attorney for filings is routine for large asset managers and confirms delegated filing authority. From a governance standpoint, this is a material disclosure of institutional ownership but does not by itself signal a change in board-level dynamics or control intentions.

Janus Henderson Group plc ha reso nota una rilevante posizione passiva in Lexeo Therapeutics, dichiarando la titolarità effettiva di 3.684.383 azioni, pari al 11,1% del capitale ordinario della società. La comunicazione precisa che sulle azioni sussiste una potestà di voto e dispositiva condivisa, non il controllo esclusivo, e il dichiarante attesta che le partecipazioni sono detenute nell'ordinario esercizio dell'attività e non con l'intento di modificare o influenzare il controllo.

Separatamente, Janus Henderson Biotech Innovation Master Fund Ltd risulta essere titolare effettivo di 2.041.481 azioni (circa il 6,2%) con analoga potestà di voto e dispositiva condivisa. La comunicazione include inoltre una procura che autorizza il personale di Janus Henderson a presentare le necessarie comunicazioni regolamentari per conto del gruppo.

Janus Henderson Group plc declaró una posición pasiva significativa en Lexeo Therapeutics, informando la propiedad beneficiaria de 3.684.383 acciones, que representan el 11,1% del capital social ordinario. La presentación señala que existe poder de voto y dispositvo compartido sobre dichas acciones en lugar de control exclusivo, y el declarante certifica que las participaciones se mantienen en el curso ordinario de negocios y no con la finalidad de cambiar o influir en el control.

Por separado, Janus Henderson Biotech Innovation Master Fund Ltd figura como titular beneficiario de 2.041.481 acciones (aproximadamente el 6,2%) con poder de voto y dispositivo compartido. La presentación incluye además un poder que autoriza al personal de Janus Henderson a realizar las presentaciones reglamentarias requeridas en nombre del grupo.

Janus Henderson Group plc� Lexeo Therapeutics� 대� 중요� 수동� 지분을 공시하며, 회사 보통� � 3,684,383�� 실질 보유하고 있어 전체� 11.1%� 해당한다� 보고했습니다. 제출 문서에는 해당 주식� 대� 단독 통제가 아니� 공동 의결� � 처분�� 있음� 명시하고 있으�, 보유 물량� 영업� 통상� 범위에서 보유되고 있으� 지배권� 변경하거나 영향� 주려� 목적� 아님� 신고인이 증명하고 있습니다.

별도�, Janus Henderson Biotech Innovation Master Fund Ltd� � 6.2%� 해당하는 2,041,481�� 실질 보유� 것으� 보고되었으며 마찬가지� 공동 의결� � 처분권을 보유하고 있습니다. 제출 문서에는 그룹� 대신해 필요� 규제 신고� � � 있도� Janus Henderson 직원들에� 위임장을 부여한 내용� 포함되어 있습니다.

Janus Henderson Group plc a déclaré une position passive significative dans Lexeo Therapeutics, signalant la propriété bénéficiaire de 3 684 383 actions, représentant 11,1% du capital social ordinaire. Le dépôt indique qu'il existe un pouvoir de vote et de disposition partagé sur ces actions plutôt qu'un contrôle exclusif, et le déclarant certifie que les détentions sont maintenues dans le cours normal des affaires et n'ont pas pour but de modifier ou d'influencer le contrôle.

é貹éԳ, Janus Henderson Biotech Innovation Master Fund Ltd détiendrait effectivement 2 041 481 actions (environ 6,2%) avec un même pouvoir de vote et de disposition partagé. Le dossier comprend également une procuration autorisant le personnel de Janus Henderson à effectuer les déclarations réglementaires requises au nom du groupe.

Janus Henderson Group plc hat eine bedeutende passive Beteiligung an Lexeo Therapeutics gemeldet und gibt den wirtschaftlichen Besitz von 3.684.383 Aktien an, was 11,1% des Stammkapitals entspricht. Die Meldung weist darauf hin, dass über diese Aktien gemeinsame Stimm- und Verfügungsbefugnisse bestehen und kein alleiniger Kontrollanspruch vorliegt; der Meldende bestätigt, dass die Bestände im gewöhnlichen Geschäftsverkehr gehalten werden und nicht dazu dienen, die Kontrolle zu ändern oder zu beeinflussen.

Separat wird angegeben, dass Janus Henderson Biotech Innovation Master Fund Ltd wirtschaftlich 2.041.481 Aktien (etwa 6,2%) hält, ebenfalls mit gemeinsamer Stimm- und Verfügungsbefugnis. Die Meldung enthält zudem eine Vollmacht, die Janus Henderson-Mitarbeiter zur Abgabe der erforderlichen regulatorischen Meldungen im Namen der Gruppe ermächtigt.






Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)






SCHEDULE 13G





SCHEDULE 13G





SCHEDULE 13G



JANUS HENDERSON GROUP PLC
Signature:Kristin Mariani
Name/Title:Head of North America Compliance, CCO
Date:08/14/2025
Janus Henderson Biotech Innovation Master Fund Ltd
Signature:Kristin Mariani
Name/Title:Head of North America Compliance, CCO
Date:08/14/2025
Exhibit Information

POWER OF ATTORNEY The undersigned, Janus Henderson Group plc ("the Company"), does hereby make, constitute and appoint each of Kristin Mariani and Caroline Barotti acting severally, as its true and lawful attorneys in-fact, for the purpose of, from time to time, executing in its name and on its behalf, whether the Company individually or as representative of others, any and all documents, certificates, instruments, statements, other filings and amendments to the foregoing (collectively, "documents") determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including, without limitation, Forms 13D, 13F, 13G and 13H and any amendments to any of the foregoing as may be required to be filed with the Securities and Exchange Commission, and delivering, furnishing or filing any such documents with the appropriate governmental, regulatory authority or other person, and giving and granting to each such attorney-in-fact power and authority to act in the premises as fully and to all intents and purposes as the Company might or could do if personally present by one of its authorized signatories, hereby ratifying and confirming all that said attorney-in-fact shall lawfully do or cause to be done by virtue hereof. Any such determination by an attorney-in-fact named herein shall be conclusively evidenced by such person's execution, delivery, furnishing or filing of the applicable document. This power of attorney shall be valid from the date hereof and shall remain in full force and effect until either revoked in writing by the Company, or, in respect of any attorney-in-fact named herein, until such person ceases to be an employee of the Company or one of its affiliates. IN WITNESS WHEREOF, the undersigned has caused this power of attorney to be executed as of this 9th day of December, 2022. Janus Henderson Group plc By: /s/ Michelle Rosenberg Name: Michelle Rosenberg Title: General Counsel and Company Secretary

FAQ

How many LXEO shares does Janus Henderson Group plc report owning?

The filing reports Janus Henderson Group plc beneficially owns 3,684,383 shares of Lexeo Therapeutics common stock.

What percent of LXEO does Janus Henderson Group plc own?

Janus Henderson Group plc's reported position represents 11.1% of the outstanding common stock.

Does the filing indicate Janus Henderson intends to influence control of Lexeo (LXEO)?

No. The schedule includes a certification that the securities are held in the ordinary course of business and were not acquired to change or influence control.

What stake does Janus Henderson Biotech Innovation Master Fund Ltd report in LXEO?

That fund reports beneficial ownership of 2,041,481 shares, or approximately 6.2% of the class.

What voting and dispositive power is reported?

The filing reports shared voting and shared dispositive power over the reported shares rather than sole voting or dispositive power.
Lexeo Therapeutics Inc

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Biotechnology
Biological Products, (no Disgnostic Substances)
United States
NEW YORK