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[SCHEDULE 13G/A] Monopar Therapeutics Inc. SEC Filing

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
SCHEDULE 13G/A
Rhea-AI Filing Summary

Janus Henderson Group plc reports a substantial disclosed holding in Monopar Therapeutics Inc. The filing shows the group beneficially owns 1,172,368 shares of Monopar common stock, representing 19.2% of the class, held with shared voting and shared dispositive power and no sole voting or dispositive power. A related vehicle, Janus Henderson Biotech Innovation Master Fund Ltd, holds 1,006,928 shares ( 16.5%). The filing states these securities are held in the ordinary course of business and were not acquired to change or influence control. The filing also includes a power of attorney authorizing named compliance officers to execute required ownership reports.

Janus Henderson Group plc comunica una partecipazione rilevante resa pubblica in Monopar Therapeutics Inc. La dichiarazione indica che il gruppo detiene beneficiariamente 1.172.368 azioni del capitale ordinario di Monopar, pari al 19,2% della classe, con potere di voto condiviso e potere dispositivo condiviso e senza potere di voto o potere dispositivo esclusivo. Un veicolo correlato, Janus Henderson Biotech Innovation Master Fund Ltd, detiene 1.006.928 azioni (16,5%). La comunicazione precisa che questi titoli sono detenuti nell'ambito ordinario dell'attività aziendale e non sono stati acquisiti per modificare o influenzare il controllo. La dichiarazione include inoltre una procura che autorizza i responsabili della conformità indicati a presentare i rapporti di proprietà richiesti.

Janus Henderson Group plc comunica una tenencia divulgada significativa en Monopar Therapeutics Inc. El formulario indica que el grupo posee a título beneficiario 1.172.368 acciones de las acciones ordinarias de Monopar, lo que representa el 19,2% de la clase, con poder de voto compartido y facultad dispositiva compartida y sin facultad dispositiva ni de voto exclusiva. Un vehículo relacionado, Janus Henderson Biotech Innovation Master Fund Ltd, posee 1.006.928 acciones (16,5%). El documento señala que estos valores se mantienen en el curso ordinario del negocio y no se adquirieron para cambiar o influir en el control. El informe también incluye un poder que autoriza a los responsables de cumplimiento nombrados a presentar los informes de propiedad requeridos.

Janus Henderson Group plc� Monopar Therapeutics Inc.� 대� 중요� 공시 지분을 보고했습니다. 제출 서류� 따르� 그룹은 Monopar 보통� 1,172,368�� 실질적으� 보유하고 있으� 이 해당 등급� 19.2%� 해당하고, 공동 의결� � 공동 처분�으로 보유되어 단독 의결권이� 단독 처분권은 없다� 기재되어 있습니다. 관� 기관� Janus Henderson Biotech Innovation Master Fund Ltd1,006,928�(16.5%)� 보유하고 있습니다. 서류에 � 증권들이 통상적인 영업 과정에서 보유� 것이� 지배권� 변경하거나 영향력을 행사하기 위해 취득� 것이 아니라 내용� 포함되어 있습니다. 또한 명시� 준법감� 담당자들� 필수 소유 보고서를 제출� � 있도� 하 위임장도 포함되어 있습니다.

Janus Henderson Group plc déclare une participation importante portée à connaissance dans Monopar Therapeutics Inc. Le dépôt indique que le groupe détient à titre bénéficiaire 1 172 368 actions d'actions ordinaires de Monopar, représentant 19,2 % de la catégorie, détenues avec pouvoir de vote partagé et pouvoir dispositif partagé, et sans pouvoir de vote ni pouvoir dispositif exclusif. Un véhicule lié, Janus Henderson Biotech Innovation Master Fund Ltd, détient 1 006 928 actions (16,5 %). Le dépôt précise que ces titres sont détenus dans le cadre normal des activités et n'ont pas été acquis dans le but de modifier ou d'influencer le contrôle. Le dossier inclut également une procuration autorisant les responsables conformité nommés à remplir les déclarations de détention requises.

Janus Henderson Group plc meldet eine wesentliche offenlegungspflichtige Beteiligung an Monopar Therapeutics Inc. Die Einreichung weist aus, dass die Gruppe wirtschaftlich 1.172.368 Aktien der Stammaktien von Monopar hält, was 19,2% der Klasse entspricht, und diese mit gemeinsamen Stimmrechten und gemeinsamer Verfügungsbefugnis gehalten werden, ohne alleinige Stimm- oder Verfügungsbefugnis. Ein verbundenes Vehikel, Janus Henderson Biotech Innovation Master Fund Ltd, hält 1.006.928 Aktien (16,5%). In der Meldung heißt es, dass diese Wertpapiere im gewöhnlichen Geschäftsbetrieb gehalten werden und nicht erworben wurden, um die Kontrolle zu ändern oder zu beeinflussen. Die Einreichung enthält außerdem eine Vollmacht, die benannte Compliance-Beauftragte bevollmächtigt, die erforderlichen Eigentumsberichte zu unterzeichnen.

Positive
  • Material disclosure of 19.2% ownership (1,172,368 shares) by Janus Henderson Group plc
  • Related fund holds 16.5% (1,006,928 shares), showing substantial investor interest
  • Holdings reported with shared voting and dispositive power, not sole control
  • Filing states securities were acquired and are held in the ordinary course, not to change control
  • Power of attorney included to authorize compliance officers to make required filings
Negative
  • None.

Insights

TL;DR Janus Henderson disclosed a material 19.2% stake in MNPR, a significant ownership position disclosed on Schedule 13G/A.

The holding of 1,172,368 shares (19.2%) is large relative to the public float and qualifies as a material position that must be disclosed. The report clarifies the position is held in the ordinary course of business and not for the purpose of changing control, and the group reports shared voting and dispositive powers rather than sole control. For investors, this confirms concentrated institutional interest but does not, per the filing, indicate an active campaign to influence governance.

TL;DR A near-20% beneficial ownership with shared voting power is material and could translate to governance influence, though the filer disclaims control intent.

The disclosure shows Janus Henderson Group plc and a related fund together occupy large stakes (19.2% and 16.5% individually). The filing records shared voting and dispositive power and an explicit certification that the securities are not held to effect control changes. The inclusion of a power of attorney for compliance officers to file reports is standard governance practice for group filings and ensures timely regulatory compliance.

Janus Henderson Group plc comunica una partecipazione rilevante resa pubblica in Monopar Therapeutics Inc. La dichiarazione indica che il gruppo detiene beneficiariamente 1.172.368 azioni del capitale ordinario di Monopar, pari al 19,2% della classe, con potere di voto condiviso e potere dispositivo condiviso e senza potere di voto o potere dispositivo esclusivo. Un veicolo correlato, Janus Henderson Biotech Innovation Master Fund Ltd, detiene 1.006.928 azioni (16,5%). La comunicazione precisa che questi titoli sono detenuti nell'ambito ordinario dell'attività aziendale e non sono stati acquisiti per modificare o influenzare il controllo. La dichiarazione include inoltre una procura che autorizza i responsabili della conformità indicati a presentare i rapporti di proprietà richiesti.

Janus Henderson Group plc comunica una tenencia divulgada significativa en Monopar Therapeutics Inc. El formulario indica que el grupo posee a título beneficiario 1.172.368 acciones de las acciones ordinarias de Monopar, lo que representa el 19,2% de la clase, con poder de voto compartido y facultad dispositiva compartida y sin facultad dispositiva ni de voto exclusiva. Un vehículo relacionado, Janus Henderson Biotech Innovation Master Fund Ltd, posee 1.006.928 acciones (16,5%). El documento señala que estos valores se mantienen en el curso ordinario del negocio y no se adquirieron para cambiar o influir en el control. El informe también incluye un poder que autoriza a los responsables de cumplimiento nombrados a presentar los informes de propiedad requeridos.

Janus Henderson Group plc� Monopar Therapeutics Inc.� 대� 중요� 공시 지분을 보고했습니다. 제출 서류� 따르� 그룹은 Monopar 보통� 1,172,368�� 실질적으� 보유하고 있으� 이 해당 등급� 19.2%� 해당하고, 공동 의결� � 공동 처분�으로 보유되어 단독 의결권이� 단독 처분권은 없다� 기재되어 있습니다. 관� 기관� Janus Henderson Biotech Innovation Master Fund Ltd1,006,928�(16.5%)� 보유하고 있습니다. 서류에 � 증권들이 통상적인 영업 과정에서 보유� 것이� 지배권� 변경하거나 영향력을 행사하기 위해 취득� 것이 아니라 내용� 포함되어 있습니다. 또한 명시� 준법감� 담당자들� 필수 소유 보고서를 제출� � 있도� 하 위임장도 포함되어 있습니다.

Janus Henderson Group plc déclare une participation importante portée à connaissance dans Monopar Therapeutics Inc. Le dépôt indique que le groupe détient à titre bénéficiaire 1 172 368 actions d'actions ordinaires de Monopar, représentant 19,2 % de la catégorie, détenues avec pouvoir de vote partagé et pouvoir dispositif partagé, et sans pouvoir de vote ni pouvoir dispositif exclusif. Un véhicule lié, Janus Henderson Biotech Innovation Master Fund Ltd, détient 1 006 928 actions (16,5 %). Le dépôt précise que ces titres sont détenus dans le cadre normal des activités et n'ont pas été acquis dans le but de modifier ou d'influencer le contrôle. Le dossier inclut également une procuration autorisant les responsables conformité nommés à remplir les déclarations de détention requises.

Janus Henderson Group plc meldet eine wesentliche offenlegungspflichtige Beteiligung an Monopar Therapeutics Inc. Die Einreichung weist aus, dass die Gruppe wirtschaftlich 1.172.368 Aktien der Stammaktien von Monopar hält, was 19,2% der Klasse entspricht, und diese mit gemeinsamen Stimmrechten und gemeinsamer Verfügungsbefugnis gehalten werden, ohne alleinige Stimm- oder Verfügungsbefugnis. Ein verbundenes Vehikel, Janus Henderson Biotech Innovation Master Fund Ltd, hält 1.006.928 Aktien (16,5%). In der Meldung heißt es, dass diese Wertpapiere im gewöhnlichen Geschäftsbetrieb gehalten werden und nicht erworben wurden, um die Kontrolle zu ändern oder zu beeinflussen. Die Einreichung enthält außerdem eine Vollmacht, die benannte Compliance-Beauftragte bevollmächtigt, die erforderlichen Eigentumsberichte zu unterzeichnen.






Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)






SCHEDULE 13G





SCHEDULE 13G





SCHEDULE 13G



JANUS HENDERSON GROUP PLC
Signature:Kristin Mariani
Name/Title:Head of North America Compliance, CCO
Date:08/14/2025
Janus Henderson Biotech Innovation Master Fund Ltd
Signature:Kristin Mariani
Name/Title:Head of North America Compliance, CCO
Date:08/14/2025
Exhibit Information

POWER OF ATTORNEY The undersigned, Janus Henderson Group plc ("the Company"), does hereby make, constitute and appoint each of Kristin Mariani and Caroline Barotti acting severally, as its true and lawful attorneys in-fact, for the purpose of, from time to time, executing in its name and on its behalf, whether the Company individually or as representative of others, any and all documents, certificates, instruments, statements, other filings and amendments to the foregoing (collectively, "documents") determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including, without limitation, Forms 13D, 13F, 13G and 13H and any amendments to any of the foregoing as may be required to be filed with the Securities and Exchange Commission, and delivering, furnishing or filing any such documents with the appropriate governmental, regulatory authority or other person, and giving and granting to each such attorney-in-fact power and authority to act in the premises as fully and to all intents and purposes as the Company might or could do if personally present by one of its authorized signatories, hereby ratifying and confirming all that said attorney-in-fact shall lawfully do or cause to be done by virtue hereof. Any such determination by an attorney-in-fact named herein shall be conclusively evidenced by such person's execution, delivery, furnishing or filing of the applicable document. This power of attorney shall be valid from the date hereof and shall remain in full force and effect until either revoked in writing by the Company, or, in respect of any attorney-in-fact named herein, until such person ceases to be an employee of the Company or one of its affiliates. IN WITNESS WHEREOF, the undersigned has caused this power of attorney to be executed as of this 9th day of December, 2022. Janus Henderson Group plc By: /s/ Michelle Rosenberg Name: Michelle Rosenberg Title: General Counsel and Company Secretary

FAQ

Who filed this Schedule 13G/A for MNPR?

Janus Henderson Group plc and Janus Henderson Biotech Innovation Master Fund Ltd are the reporting persons listed in the filing.

How many Monopar (MNPR) shares does Janus Henderson Group plc report owning?

1,172,368 shares, representing 19.2% of the class, held with shared voting and dispositive power.

How many shares does Janus Henderson Biotech Innovation Master Fund Ltd report?

1,006,928 shares, representing 16.5% of the class, with shared voting and dispositive power.

Does the filing state the intent behind the holdings in MNPR?

Yes; the filing certifies the shares are held in the ordinary course of business and were not acquired to change or influence control of the issuer.

Who signed the filing on behalf of the reporting persons?

Kristin Mariani, Head of North America Compliance, CCO, signed the filing on behalf of both reporting entities.
Monopar Therapeutics Inc

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Biotechnology
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United States
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