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Item 5.02 8-K: On 18 Jul 2025 Lixte Biotechnology appointed Jason Sawyer and Dr. Michael Holloway as independent directors under designation rights granted to investors that bought 3,573,190 Series B Preferred Shares on 3 Jul 2025. Sawyer also becomes Chair of the Compensation Committee and joins the Audit Committee.

To accommodate the appointments, Dr. Stephen Forman and Dr. Yun Yen resigned from the Board and moved to the company’s Scientific Advisory Committee. The company states these departures were not due to disagreements.

Separately, Chief Medical Officer Dr. Jan Schellens tendered his resignation and his consulting agreement will end 31 Jul 2025 so he can pursue other opportunities; no disputes were cited.

No financial results, guidance, or operational metrics were provided—this filing is strictly a corporate-governance update linked to the recent preferred-equity financing.

Voce 5.02 8-K: Il 18 luglio 2025 Lixte Biotechnology ha nominato Jason Sawyer e il dott. Michael Holloway come amministratori indipendenti, in base ai diritti di designazione concessi agli investitori che hanno acquistato 3.573.190 azioni privilegiate di Serie B il 3 luglio 2025. Sawyer è inoltre diventato Presidente del Comitato per la Remunerazione e membro del Comitato di Revisione.

Per consentire queste nomine, il dott. Stephen Forman e il dott. Yun Yen si sono dimessi dal Consiglio di Amministrazione e sono passati al Comitato Consultivo Scientifico dell’azienda. La società ha dichiarato che queste dimissioni non sono dovute a disaccordi.

Separatamente, il Direttore Medico, dott. Jan Schellens, ha presentato le dimissioni e il suo contratto di consulenza terminerà il 31 luglio 2025 per permettergli di perseguire altre opportunità; non sono state segnalate controversie.

Non sono stati forniti risultati finanziari, previsioni o indicatori operativi: questa comunicazione riguarda esclusivamente un aggiornamento sulla governance aziendale collegato al recente finanziamento tramite azioni privilegiate.

Artículo 5.02 8-K: El 18 de julio de 2025, Lixte Biotechnology nombró a Jason Sawyer y al Dr. Michael Holloway como directores independientes bajo los derechos de designación otorgados a los inversores que compraron 3,573,190 acciones preferentes Serie B el 3 de julio de 2025. Sawyer también se convierte en presidente del Comité de Compensación y se une al Comité de Auditoría.

Para facilitar los nombramientos, el Dr. Stephen Forman y el Dr. Yun Yen renunciaron a la Junta y pasaron al Comité Asesor Científico de la empresa. La compañía afirma que estas salidas no se debieron a desacuerdos.

Por separado, el Director Médico, Dr. Jan Schellens, presentó su renuncia y su contrato de consultoría finalizará el 31 de julio de 2025 para que pueda buscar otras oportunidades; no se mencionaron disputas.

No se proporcionaron resultados financieros, pronósticos ni métricas operativas; esta presentación es estrictamente una actualización de gobierno corporativo relacionada con la reciente financiación de acciones preferentes.

항목 5.02 8-K: 2025ë…� 7ì›� 18ì�, Lixte BiotechnologyëŠ� 2025ë…� 7ì›� 3ì¼ì— 3,573,190ì£¼ì˜ ì‹œë¦¬ì¦� B 우선주를 구매í•� 투ìžìžì—ê²� ë¶€ì—¬ëœ ì§€ëª� 권리ì—� ë”°ë¼ Jason Sawyer와 Dr. Michael Hollowayë¥� ë…립 ì´ì‚¬ë¡� 임명했습니다. SawyerëŠ� ë˜í•œ ë³´ìƒìœ„ì›íš� ì˜ìž¥ì´ìž ê°ì‚¬ìœ„ì›íš� 위ì›ì� ë˜ì—ˆìŠµë‹ˆë‹�.

ì� 임명ì� 수용하기 위해 Dr. Stephen Formanê³� Dr. Yun Yenì€ ì´ì‚¬íšŒì—ì„� 사임하고 회사ì� 과학 ìžë¬¸ 위ì›íšŒë¡œ ì´ë™í–ˆìŠµë‹ˆë‹¤. 회사ëŠ� ì´ë“¤ì� 사임ì� ì˜ê²¬ ì°¨ì´ ë•Œë¬¸ì� 아니ë¼ê³  ë°í˜”습니ë‹�.

별ë„ë¡�, 최고 ì˜ë£Œ ì±…ìž„ìžì¸ Dr. Jan SchellensëŠ� 사임 ì˜ì‚¬ë¥� ë°í˜”으며, ê·¸ì˜ ì»¨ì„¤íŒ� ê³„ì•½ì€ 2025ë…� 7ì›� 31ì� 종료ë˜ì–´ 다른 기회ë¥� 추구í•� 예정입니ë‹�; ë¶„ìŸì€ 없었습니ë‹�.

재무 실ì , ê°€ì´ë“œë¼ì¸ ë˜ëŠ” ìš´ì˜ ì§€í‘œëŠ” 제공ë˜ì§€ 않았으며, ì´ë²ˆ ì œì¶œì€ ìµœê·¼ ìš°ì„ ì£� ìžê¸ˆ 조달ê³� ê´€ë ¨ëœ ê¸°ì—… 거버넌스 ì—…ë°ì´íЏì—� 한정ë©ë‹ˆë‹�.

Point 5.02 8-K : Le 18 juillet 2025, Lixte Biotechnology a nommé Jason Sawyer et le Dr Michael Holloway en tant qu’administrateurs indépendants, conformément aux droits de désignation accordés aux investisseurs ayant acquis 3 573 190 actions privilégiées de série B le 3 juillet 2025. Sawyer devient également président du comité de rémunération et rejoint le comité d’audit.

Pour permettre ces nominations, le Dr Stephen Forman et le Dr Yun Yen ont démissionné du conseil d’administration et ont rejoint le comité consultatif scientifique de l’entreprise. La société précise que ces départs ne sont pas dus à des désaccords.

Par ailleurs, le directeur médical, le Dr Jan Schellens, a présenté sa démission et son contrat de consultant prendra fin le 31 juillet 2025 afin qu’il puisse poursuivre d’autres opportunités ; aucun différend n’a été signalé.

Aucun résultat financier, prévision ou indicateur opérationnel n’a été fourni � ce dépôt est strictement une mise à jour de la gouvernance d’entreprise liée au récent financement par actions privilégiées.

Punkt 5.02 8-K: Am 18. Juli 2025 ernannte Lixte Biotechnology Jason Sawyer und Dr. Michael Holloway als unabhängige Direktoren gemäß den Benennungsrechten, die Investoren eingeräumt wurden, die am 3. Juli 2025 3.573.190 Series B Vorzugsaktien erworben hatten. Sawyer wurde zudem Vorsitzender des Vergütungsausschusses und Mitglied des Prüfungsausschusses.

Um die Ernennungen zu ermöglichen, traten Dr. Stephen Forman und Dr. Yun Yen aus dem Vorstand zurück und wechselten in den Wissenschaftlichen Beirat des Unternehmens. Das Unternehmen gab an, dass diese Abgänge nicht auf Meinungsverschiedenheiten zurückzuführen sind.

Separat reichte der Chief Medical Officer Dr. Jan Schellens seinen Rücktritt ein, und sein Beratungsvertrag endet am 31. Juli 2025, damit er andere Möglichkeiten verfolgen kann; es wurden keine Streitigkeiten angegeben.

Es wurden keine Finanzergebnisse, Prognosen oder operative Kennzahlen bereitgestellt � diese Meldung ist ausschließlich ein Update zur Unternehmensführung im Zusammenhang mit der jüngsten Vorzugsaktienfinanzierung.

Positive
  • Preferred-shareholder representation adds two independent directors, potentially strengthening oversight and aligning new capital with governance.
  • Reassignment of departing directors to the Scientific Advisory Committee retains domain expertise, limiting knowledge loss.
Negative
  • Chief Medical Officer resignation may slow clinical development and poses leadership continuity risk.
  • Multiple board departures in a short window can create strategic uncertainty and distract management.

Insights

TL;DR: Board expands to include preferred-shareholder nominees; independent oversight rises, but key executive exits.

The Series B investors have swiftly exercised their right to place two nominees on the Board, increasing shareholder representation and potentially improving governance. Sawyer’s instant elevation to Compensation Committee chair implies influence over pay policy. Reassignment of Forman and Yen to the Scientific Advisory Committee preserves institutional knowledge, mitigating disruption. However, simultaneous turnover of three directors plus the CMO creates near-term execution risk. Overall impact appears balanced.

TL;DR: Governance shuffle after financing; CMO departure raises pipeline execution questions.

Adding investor-backed directors may speed strategic decisions and signal confidence from new capital. Yet losing the CMO during clinical development could delay trials, require recruiting costs, and unsettle partner discussions. Because no programs were referenced, the operational effect is uncertain but potentially negative if replacement lags. Net impact: neutral-to-slightly negative until a suitable scientific leader is hired.

Voce 5.02 8-K: Il 18 luglio 2025 Lixte Biotechnology ha nominato Jason Sawyer e il dott. Michael Holloway come amministratori indipendenti, in base ai diritti di designazione concessi agli investitori che hanno acquistato 3.573.190 azioni privilegiate di Serie B il 3 luglio 2025. Sawyer è inoltre diventato Presidente del Comitato per la Remunerazione e membro del Comitato di Revisione.

Per consentire queste nomine, il dott. Stephen Forman e il dott. Yun Yen si sono dimessi dal Consiglio di Amministrazione e sono passati al Comitato Consultivo Scientifico dell’azienda. La società ha dichiarato che queste dimissioni non sono dovute a disaccordi.

Separatamente, il Direttore Medico, dott. Jan Schellens, ha presentato le dimissioni e il suo contratto di consulenza terminerà il 31 luglio 2025 per permettergli di perseguire altre opportunità; non sono state segnalate controversie.

Non sono stati forniti risultati finanziari, previsioni o indicatori operativi: questa comunicazione riguarda esclusivamente un aggiornamento sulla governance aziendale collegato al recente finanziamento tramite azioni privilegiate.

Artículo 5.02 8-K: El 18 de julio de 2025, Lixte Biotechnology nombró a Jason Sawyer y al Dr. Michael Holloway como directores independientes bajo los derechos de designación otorgados a los inversores que compraron 3,573,190 acciones preferentes Serie B el 3 de julio de 2025. Sawyer también se convierte en presidente del Comité de Compensación y se une al Comité de Auditoría.

Para facilitar los nombramientos, el Dr. Stephen Forman y el Dr. Yun Yen renunciaron a la Junta y pasaron al Comité Asesor Científico de la empresa. La compañía afirma que estas salidas no se debieron a desacuerdos.

Por separado, el Director Médico, Dr. Jan Schellens, presentó su renuncia y su contrato de consultoría finalizará el 31 de julio de 2025 para que pueda buscar otras oportunidades; no se mencionaron disputas.

No se proporcionaron resultados financieros, pronósticos ni métricas operativas; esta presentación es estrictamente una actualización de gobierno corporativo relacionada con la reciente financiación de acciones preferentes.

항목 5.02 8-K: 2025ë…� 7ì›� 18ì�, Lixte BiotechnologyëŠ� 2025ë…� 7ì›� 3ì¼ì— 3,573,190ì£¼ì˜ ì‹œë¦¬ì¦� B 우선주를 구매í•� 투ìžìžì—ê²� ë¶€ì—¬ëœ ì§€ëª� 권리ì—� ë”°ë¼ Jason Sawyer와 Dr. Michael Hollowayë¥� ë…립 ì´ì‚¬ë¡� 임명했습니다. SawyerëŠ� ë˜í•œ ë³´ìƒìœ„ì›íš� ì˜ìž¥ì´ìž ê°ì‚¬ìœ„ì›íš� 위ì›ì� ë˜ì—ˆìŠµë‹ˆë‹�.

ì� 임명ì� 수용하기 위해 Dr. Stephen Formanê³� Dr. Yun Yenì€ ì´ì‚¬íšŒì—ì„� 사임하고 회사ì� 과학 ìžë¬¸ 위ì›íšŒë¡œ ì´ë™í–ˆìŠµë‹ˆë‹¤. 회사ëŠ� ì´ë“¤ì� 사임ì� ì˜ê²¬ ì°¨ì´ ë•Œë¬¸ì� 아니ë¼ê³  ë°í˜”습니ë‹�.

별ë„ë¡�, 최고 ì˜ë£Œ ì±…ìž„ìžì¸ Dr. Jan SchellensëŠ� 사임 ì˜ì‚¬ë¥� ë°í˜”으며, ê·¸ì˜ ì»¨ì„¤íŒ� ê³„ì•½ì€ 2025ë…� 7ì›� 31ì� 종료ë˜ì–´ 다른 기회ë¥� 추구í•� 예정입니ë‹�; ë¶„ìŸì€ 없었습니ë‹�.

재무 실ì , ê°€ì´ë“œë¼ì¸ ë˜ëŠ” ìš´ì˜ ì§€í‘œëŠ” 제공ë˜ì§€ 않았으며, ì´ë²ˆ ì œì¶œì€ ìµœê·¼ ìš°ì„ ì£� ìžê¸ˆ 조달ê³� ê´€ë ¨ëœ ê¸°ì—… 거버넌스 ì—…ë°ì´íЏì—� 한정ë©ë‹ˆë‹�.

Point 5.02 8-K : Le 18 juillet 2025, Lixte Biotechnology a nommé Jason Sawyer et le Dr Michael Holloway en tant qu’administrateurs indépendants, conformément aux droits de désignation accordés aux investisseurs ayant acquis 3 573 190 actions privilégiées de série B le 3 juillet 2025. Sawyer devient également président du comité de rémunération et rejoint le comité d’audit.

Pour permettre ces nominations, le Dr Stephen Forman et le Dr Yun Yen ont démissionné du conseil d’administration et ont rejoint le comité consultatif scientifique de l’entreprise. La société précise que ces départs ne sont pas dus à des désaccords.

Par ailleurs, le directeur médical, le Dr Jan Schellens, a présenté sa démission et son contrat de consultant prendra fin le 31 juillet 2025 afin qu’il puisse poursuivre d’autres opportunités ; aucun différend n’a été signalé.

Aucun résultat financier, prévision ou indicateur opérationnel n’a été fourni � ce dépôt est strictement une mise à jour de la gouvernance d’entreprise liée au récent financement par actions privilégiées.

Punkt 5.02 8-K: Am 18. Juli 2025 ernannte Lixte Biotechnology Jason Sawyer und Dr. Michael Holloway als unabhängige Direktoren gemäß den Benennungsrechten, die Investoren eingeräumt wurden, die am 3. Juli 2025 3.573.190 Series B Vorzugsaktien erworben hatten. Sawyer wurde zudem Vorsitzender des Vergütungsausschusses und Mitglied des Prüfungsausschusses.

Um die Ernennungen zu ermöglichen, traten Dr. Stephen Forman und Dr. Yun Yen aus dem Vorstand zurück und wechselten in den Wissenschaftlichen Beirat des Unternehmens. Das Unternehmen gab an, dass diese Abgänge nicht auf Meinungsverschiedenheiten zurückzuführen sind.

Separat reichte der Chief Medical Officer Dr. Jan Schellens seinen Rücktritt ein, und sein Beratungsvertrag endet am 31. Juli 2025, damit er andere Möglichkeiten verfolgen kann; es wurden keine Streitigkeiten angegeben.

Es wurden keine Finanzergebnisse, Prognosen oder operative Kennzahlen bereitgestellt � diese Meldung ist ausschließlich ein Update zur Unternehmensführung im Zusammenhang mit der jüngsten Vorzugsaktienfinanzierung.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Abou John P.

(Last) (First) (Middle)
100 CONGRESS AVENUE
SUITE 1425

(Street)
AUSTIN TX 78701

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
TTEC Holdings, Inc. [ TTEC ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
President, TTEC Engage
3. Date of Earliest Transaction (Month/Day/Year)
07/17/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock(1) 07/17/2025 M 19,480 A $0 19,480 D
Common Stock(2) 07/17/2025 F 7,023 D $4.97 12,457 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Restricted Stock Units(1) $0 07/17/2025 M 19,480 (1) (1) Common Stock 19,480 $0 77,923 D
Explanation of Responses:
1. Reflects vesting of Restricted Stock Units ("RSUs") on July 17, 2025. The Reporting Person initially received 97,403 time-based RSUs on July 17, 2024. The RSUs vest in five installments of 20% per year beginning on July 17, 2025.
2. Reflects withholding of shares to satisfy tax obligations in connection with the vesting of RSUs. No shares were sold.
/s/ Margaret B. McLean, Attorney-in-Fact for John P. Abou 07/21/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

Why did LIXT file an 8-K on 21 Jul 2025?

The company reported board changes, including the appointment of two new independent directors and resignation of its Chief Medical Officer.

Who are the new directors of Lixte Biotechnology (LIXT)?

Jason Sawyer and Dr. Michael Holloway were appointed on 18 Jul 2025 under rights held by Series B Preferred shareholders.

Did any directors resign from LIXT?

Yes. Dr. Stephen Forman and Dr. Yun Yen resigned from the Board but joined the Scientific Advisory Committee.

What committees will Jason Sawyer join?

Sawyer becomes Chairman of the Compensation Committee and a member of the Audit Committee.

When does CMO Dr. Jan Schellens leave LIXT?

His resignation and consulting agreement termination are effective 31 Jul 2025.

Were the resignations due to disagreements with the company?

The filing states that none of the resignations resulted from disagreements over operations, policies, or practices.
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