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[SCHEDULE 13G/A] Tyra Biosciences, Inc. SEC Filing

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
SCHEDULE 13G/A
Rhea-AI Filing Summary

Janus Henderson Group plc reported beneficial ownership of 2,856,290 shares of Tyra Biosciences common stock, equal to 5.4% of the class, in a Schedule 13G/A filing. The statement shows 0 shares of sole voting or dispositive power and 2,856,290 shares of shared voting and shared dispositive power, indicating the reported interest is held collectively by related entities. The filing identifies the reporting person type as IA, HC and lists indirect subsidiaries (JHIUS, JHIUKL and JHIAIFML) as registered investment advisers furnishing advice to Managed Portfolios. A power of attorney authorizes named employees to prepare and file U.S. reporting forms on the group's behalf.

Janus Henderson Group plc ha dichiarato il possesso beneficiario di 2,856,290 azioni ordinarie di Tyra Biosciences, pari al 5.4% della classe, in un deposito Schedule 13G/A. La dichiarazione indica 0 azioni con potere di voto o dispositive esclusivo e 2,856,290 azioni con potere di voto e dispositive condiviso, segnalando che l'interesse riportato è detenuto collettivamente da entità correlate. Il deposito identifica il tipo di soggetto dichiarante come IA, HC e elenca le controllate indirette (JHIUS, JHIUKL e JHIAIFML) come consulenti d'investimento registrati che forniscono consulenza a Managed Portfolios. Una procura autorizza i dipendenti nominati a preparare e presentare i moduli di segnalazione USA per conto del gruppo.

Janus Henderson Group plc informó la propiedad beneficiaria de 2,856,290 acciones ordinarias de Tyra Biosciences, equivalentes al 5.4% de la clase, en una presentación Schedule 13G/A. La declaración muestra 0 acciones con poder de voto o dispositivo exclusivo y 2,856,290 acciones con poder de voto y dispositivo compartido, lo que indica que el interés declarado se mantiene colectivamente por entidades relacionadas. La presentación identifica el tipo de declarante como IA, HC y enumera subsidiarias indirectas (JHIUS, JHIUKL y JHIAIFML) como asesores de inversión registrados que brindan asesoría a Managed Portfolios. Un poder autoriza a empleados nombrados a preparar y presentar formularios de reporte en EE. UU. en nombre del grupo.

Janus Henderson Group plc� Schedule 13G/A 제출서에� Tyra Biosciences 보통� 2,856,290�(전체 클래스의 5.4%)� 대� 수익� 소유권을 신고했습니다. 해당 신고서는 단독 의결� 또는 처분권이 0주이� 공동 의결� � 공동 처분권이 2,856,290주임� 명시하여 신고� 지분이 관� 법인들에 의해 집단적으� 보유되고 있음� 나타냅니�. 제출서에� 신고� 유형� IA, HC� 적시하고 간접 자회사들(JHIUS, JHIUKL � JHIAIFML)� 등록� 투자자문사로 기재하여 Managed Portfolios� 자문� 제공한다� 밝혔습니�. 위임장은 지정된 직원들이 그룹� 대신해 미국 신고서를 작성·제출� � 있도� 권한� 부여합니다.

Janus Henderson Group plc a déclaré, dans un dépôt Schedule 13G/A, la propriété bénéficiaire de 2,856,290 actions ordinaires de Tyra Biosciences, soit 5.4% de la catégorie. La déclaration indique 0 action avec pouvoir de vote ou d'aliénation exclusif et 2,856,290 actions avec pouvoir de vote et d'aliénation partagé, ce qui signifie que l'intérêt déclaré est détenu collectivement par des entités liées. Le dépôt identifie le type de déclarant comme IA, HC et liste des filiales indirectes (JHIUS, JHIUKL et JHIAIFML) en tant que conseillers en investissement enregistrés fournissant des conseils aux Managed Portfolios. Une procuration autorise des employés nommés à préparer et déposer les formulaires de déclaration américains au nom du groupe.

Janus Henderson Group plc meldete in einer Schedule 13G/A-Angabe den wirtschaftlichen Besitz von 2,856,290 Aktien der Stammaktien von Tyra Biosciences, entsprechend 5.4% der Klasse. Die Erklärung weist 0 Aktien mit alleinigem Stimm- oder Verfügungsrecht und 2,856,290 Aktien mit gemeinsamem Stimm- und Verfügungsrecht aus, was darauf hinweist, dass das gemeldete Interesse kollektiv von verbundenen Gesellschaften gehalten wird. Die Einreichung benennt den meldenden Personentyp als IA, HC und führt indirekte Tochtergesellschaften (JHIUS, JHIUKL und JHIAIFML) als registrierte Anlageberater auf, die Managed Portfolios beraten. Eine Vollmacht berechtigt namentlich genannte Mitarbeitende, im Namen der Gruppe US-Meldeformulare zu erstellen und einzureichen.

Positive
  • Janus Henderson disclosed beneficial ownership of 2,856,290 shares, representing a reported 5.4% interest in TYRA common stock.
  • Filing specifies shared voting and shared dispositive power of 2,856,290 shares with 0 shares of sole power, providing clear allocation of authority.
  • The report identifies the reporting person type as IA, HC and names indirect subsidiaries (JHIUS, JHIUKL and JHIAIFML) as registered investment advisers, improving transparency.
  • A documented power of attorney authorizes named employees to execute and amend U.S. reporting forms on behalf of Janus Henderson, clarifying filing authority.
Negative
  • None.

Insights

Janus Henderson reports a material 5.4% holding in TYRA via shared voting and dispositive power.

The filing discloses 2,856,290 shares and explicitly allocates shared voting and shared dispositive power to the reporting group while showing no sole voting or dispositive power. Crossing the 5% threshold triggers public reporting and signals a visible institutional position. The classification as IA, HC and the identification of investment-adviser subsidiaries clarify the channels through which the position is managed. On its face, the disclosure is a routine institutional ownership report rather than an indication of control actions.

The Schedule 13G/A and attached power of attorney reflect centralized, compliant reporting by Janus Henderson subsidiaries.

The document names JHIUS, JHIUKL and JHIAIFML as indirect subsidiaries and includes a power of attorney granting authority to specific employees to file and amend U.S. disclosure forms. That structure supports coordinated compliance across entities and clarifies who may execute reporting obligations. The statement of shared voting and dispositive power is explicit and limits ambiguity about how the position is reported within the group.

Janus Henderson Group plc ha dichiarato il possesso beneficiario di 2,856,290 azioni ordinarie di Tyra Biosciences, pari al 5.4% della classe, in un deposito Schedule 13G/A. La dichiarazione indica 0 azioni con potere di voto o dispositive esclusivo e 2,856,290 azioni con potere di voto e dispositive condiviso, segnalando che l'interesse riportato è detenuto collettivamente da entità correlate. Il deposito identifica il tipo di soggetto dichiarante come IA, HC e elenca le controllate indirette (JHIUS, JHIUKL e JHIAIFML) come consulenti d'investimento registrati che forniscono consulenza a Managed Portfolios. Una procura autorizza i dipendenti nominati a preparare e presentare i moduli di segnalazione USA per conto del gruppo.

Janus Henderson Group plc informó la propiedad beneficiaria de 2,856,290 acciones ordinarias de Tyra Biosciences, equivalentes al 5.4% de la clase, en una presentación Schedule 13G/A. La declaración muestra 0 acciones con poder de voto o dispositivo exclusivo y 2,856,290 acciones con poder de voto y dispositivo compartido, lo que indica que el interés declarado se mantiene colectivamente por entidades relacionadas. La presentación identifica el tipo de declarante como IA, HC y enumera subsidiarias indirectas (JHIUS, JHIUKL y JHIAIFML) como asesores de inversión registrados que brindan asesoría a Managed Portfolios. Un poder autoriza a empleados nombrados a preparar y presentar formularios de reporte en EE. UU. en nombre del grupo.

Janus Henderson Group plc� Schedule 13G/A 제출서에� Tyra Biosciences 보통� 2,856,290�(전체 클래스의 5.4%)� 대� 수익� 소유권을 신고했습니다. 해당 신고서는 단독 의결� 또는 처분권이 0주이� 공동 의결� � 공동 처분권이 2,856,290주임� 명시하여 신고� 지분이 관� 법인들에 의해 집단적으� 보유되고 있음� 나타냅니�. 제출서에� 신고� 유형� IA, HC� 적시하고 간접 자회사들(JHIUS, JHIUKL � JHIAIFML)� 등록� 투자자문사로 기재하여 Managed Portfolios� 자문� 제공한다� 밝혔습니�. 위임장은 지정된 직원들이 그룹� 대신해 미국 신고서를 작성·제출� � 있도� 권한� 부여합니다.

Janus Henderson Group plc a déclaré, dans un dépôt Schedule 13G/A, la propriété bénéficiaire de 2,856,290 actions ordinaires de Tyra Biosciences, soit 5.4% de la catégorie. La déclaration indique 0 action avec pouvoir de vote ou d'aliénation exclusif et 2,856,290 actions avec pouvoir de vote et d'aliénation partagé, ce qui signifie que l'intérêt déclaré est détenu collectivement par des entités liées. Le dépôt identifie le type de déclarant comme IA, HC et liste des filiales indirectes (JHIUS, JHIUKL et JHIAIFML) en tant que conseillers en investissement enregistrés fournissant des conseils aux Managed Portfolios. Une procuration autorise des employés nommés à préparer et déposer les formulaires de déclaration américains au nom du groupe.

Janus Henderson Group plc meldete in einer Schedule 13G/A-Angabe den wirtschaftlichen Besitz von 2,856,290 Aktien der Stammaktien von Tyra Biosciences, entsprechend 5.4% der Klasse. Die Erklärung weist 0 Aktien mit alleinigem Stimm- oder Verfügungsrecht und 2,856,290 Aktien mit gemeinsamem Stimm- und Verfügungsrecht aus, was darauf hinweist, dass das gemeldete Interesse kollektiv von verbundenen Gesellschaften gehalten wird. Die Einreichung benennt den meldenden Personentyp als IA, HC und führt indirekte Tochtergesellschaften (JHIUS, JHIUKL und JHIAIFML) als registrierte Anlageberater auf, die Managed Portfolios beraten. Eine Vollmacht berechtigt namentlich genannte Mitarbeitende, im Namen der Gruppe US-Meldeformulare zu erstellen und einzureichen.






Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)






SCHEDULE 13G





SCHEDULE 13G



JANUS HENDERSON GROUP PLC
Signature:Kristin Mariani
Name/Title:Head of North America Compliance, CCO
Date:08/14/2025
Exhibit Information

POWER OF ATTORNEY The undersigned, Janus Henderson Group plc ("the Company"), does hereby make, constitute and appoint each of Kristin Mariani and Caroline Barotti acting severally, as its true and lawful attorneys in-fact, for the purpose of, from time to time, executing in its name and on its behalf, whether the Company individually or as representative of others, any and all documents, certificates, instruments, statements, other filings and amendments to the foregoing (collectively, "documents") determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including, without limitation, Forms 13D, 13F, 13G and 13H and any amendments to any of the foregoing as may be required to be filed with the Securities and Exchange Commission, and delivering, furnishing or filing any such documents with the appropriate governmental, regulatory authority or other person, and giving and granting to each such attorney-in-fact power and authority to act in the premises as fully and to all intents and purposes as the Company might or could do if personally present by one of its authorized signatories, hereby ratifying and confirming all that said attorney-in-fact shall lawfully do or cause to be done by virtue hereof. Any such determination by an attorney-in-fact named herein shall be conclusively evidenced by such person's execution, delivery, furnishing or filing of the applicable document. This power of attorney shall be valid from the date hereof and shall remain in full force and effect until either revoked in writing by the Company, or, in respect of any attorney-in-fact named herein, until such person ceases to be an employee of the Company or one of its affiliates. IN WITNESS WHEREOF, the undersigned has caused this power of attorney to be executed as of this 9th day of December, 2022. Janus Henderson Group plc By: /s/ Michelle Rosenberg Name: Michelle Rosenberg Title: General Counsel and Company Secretary

FAQ

Who filed the Schedule 13G/A for TYRA?

The filing was made by Janus Henderson Group plc as the reporting person.

How many Tyra Biosciences (TYRA) shares does Janus Henderson report owning?

The filing reports beneficial ownership of 2,856,290 shares of TYRA common stock.

What percentage of TYRA does the reported holding represent?

The disclosed position represents 5.4% of the class of common stock.

What voting and dispositive powers are reported by Janus Henderson?

The filing shows 0 shares of sole voting or dispositive power and 2,856,290 shares of shared voting and shared dispositive power.

Which subsidiaries are identified as involved in managing the position?

The filing names JHIUS, JHIUKL and JHIAIFML as indirect subsidiaries that are registered investment advisers furnishing advice to Managed Portfolios.

Who signed the Schedule 13G/A on behalf of Janus Henderson?

The document is signed by Kristin Mariani, Head of North America Compliance, CCO, for Janus Henderson Group plc.
Tyra Biosciences, Inc.

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Biotechnology
Pharmaceutical Preparations
United States
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