AG˹ٷ

STOCK TITAN

[Form 4] Codexis, Inc. Insider Trading Activity

Filing Impact
(Neutral)
Filing Sentiment
(Positive)
Form Type
4
Rhea-AI Filing Summary

Codexis, Inc. (CDXS) received a Form 4 filing from Opaleye Management Inc., a 10% beneficial owner, detailing an open-market purchase completed on 27 June 2025.

  • Transaction: 100,000 shares of Codexis common stock were purchased (Code P) at an average price of $2.39 per share.
  • Post-transaction holdings: Opaleye now reports 12,350,000 shares held indirectly through Opaleye, L.P. and an additional 250,000 shares in a separately managed account, bringing total reported beneficial ownership to 12.6 million shares.
  • Ownership form: All shares are reported as indirect (Form I); the investment manager disclaims beneficial ownership beyond its pecuniary interest.
  • Reporting party status: Opaleye is classified as a 10% owner; no board or executive role is indicated.

The filing signals incremental insider accumulation by a large shareholder. While the 100 k-share purchase is modest relative to the 12.35 million-share position, fresh buying can be interpreted by investors as a vote of confidence in Codexis at current price levels. No derivative transactions, sales or options were disclosed in this filing.

Codexis, Inc. (CDXS) ha ricevuto una comunicazione Form 4 da Opaleye Management Inc., un azionista con una partecipazione del 10%, che dettaglia un acquisto sul mercato aperto completato il 27 giugno 2025.

  • Transazione: 100.000 azioni ordinarie di Codexis sono state acquistate (Codice P) a un prezzo medio di 2,39 $ per azione.
  • Detenzione post-transazione: Opaleye dichiara ora di detenere indirettamente 12.350.000 azioni tramite Opaleye, L.P. e ulteriori 250.000 azioni in un conto gestito separatamente, portando la proprietà beneficiaria totale a 12,6 milioni di azioni.
  • Forma di proprietà: Tutte le azioni sono riportate come indirette (Modulo I); il gestore degli investimenti nega la proprietà beneficiaria oltre il suo interesse pecuniario.
  • Stato della parte che segnala: Opaleye è classificata come azionista con oltre il 10%; non sono indicati ruoli nel consiglio o esecutivi.

La comunicazione indica un accumulo incrementale da parte di un grande azionista interno. Sebbene l'acquisto di 100.000 azioni sia modesto rispetto alla posizione di 12,35 milioni di azioni, il nuovo acquisto può essere interpretato dagli investitori come un segnale di fiducia in Codexis ai livelli di prezzo attuali. In questa comunicazione non sono state divulgate transazioni su derivati, vendite o opzioni.

Codexis, Inc. (CDXS) recibió una presentación Formulario 4 de Opaleye Management Inc., un propietario beneficiario del 10%, detallando una compra en el mercado abierto completada el 27 de junio de 2025.

  • հԲó: Se compraron 100,000 acciones ordinarias de Codexis (Código P) a un precio promedio de $2.39 por acción.
  • Posición posterior a la transacción: Opaleye reporta ahora 12,350,000 acciones mantenidas indirectamente a través de Opaleye, L.P. y otras 250,000 acciones en una cuenta gestionada por separado, sumando una propiedad beneficiaria total de 12.6 millones de acciones.
  • Forma de propiedad: Todas las acciones se reportan como indirectas (Formulario I); el administrador de inversiones renuncia a la propiedad beneficiaria más allá de su interés pecuniario.
  • Estado de la parte que informa: Opaleye está clasificada como un propietario del 10%; no se indica ningún rol en la junta o ejecutivo.

La presentación señala una acumulación incremental por parte de un gran accionista interno. Aunque la compra de 100,000 acciones es modesta en relación con la posición de 12.35 millones de acciones, la compra reciente puede interpretarse por los inversores como un voto de confianza en Codexis a los niveles de precio actuales. No se divulgaron transacciones con derivados, ventas u opciones en esta presentación.

Codexis, Inc. (CDXS)� 10% 지� 보유자인 Opaleye Management Inc.로부� 2025� 6� 27� 완료� 공개 시장 매수� 관� Form 4 신고� 받았습니�.

  • 거래 내용: Codexis 보통� 100,000주가 주당 평균 가� $2.39매수(코드 P)되었습니�.
  • 거래 � 보유 현황: 貹� 현재 Opaleye, L.P.� 통해 간접적으� 12,350,000주를 보유하고 있으�, 별도� 관리되� 계좌� 추가� 250,000주를 보유하여 � 보고� 실질 소유 지분은 1,260� �입니�.
  • 소유 형태: 모든 주식은 간접 소유(Form I)� 보고되었으며, 투자 매니저� 금전� 이익 이상� 실질 소유권을 부인합니다.
  • 신고� 상태: 貹� 10% 소유�� 분류되며, 이사회나 경영� 역할은 명시되어 있지 않습니다.

이번 신고� 대주주� 의한 점진적인 내부� 매입 신호입니�. 10� � 매수� 1,235� � 보유 규모� 비해 적은 편이지�, 신규 매수� 투자자들에게 현재 가� 수준에서 Codexis� 대� 신뢰� 표시� 해석� � 있습니다. 이번 신고에는 파생상품 거래, 매도 또는 옵션 거래� 포함되지 않았습니�.

Codexis, Inc. (CDXS) a reçu un dépôt de formulaire 4 de la part de Opaleye Management Inc., un détenteur bénéficiaire à 10%, détaillant un achat sur le marché libre réalisé le 27 juin 2025.

  • Transaction : 100 000 actions ordinaires de Codexis ont été achetées (Code P) à un prix moyen de 2,39 $ par action.
  • Positions après transaction : Opaleye déclare désormais détenir indirectement 12 350 000 actions via Opaleye, L.P. et un compte géré séparément avec 250 000 actions supplémentaires, portant la propriété bénéficiaire totale déclarée à 12,6 millions ’aپDzԲ.
  • Forme de propriété : Toutes les actions sont déclarées comme indirectes (Formulaire I) ; le gestionnaire d’investissement décline toute propriété bénéficiaire au-delà de son intérêt pécuniaire.
  • Statut du déclarant : Opaleye est classé comme un détenteur de 10% ; aucun rôle au conseil d’administration ou exécutif n’est indiqué.

Le dépôt signale une accumulation progressive d’initiés par un grand actionnaire. Bien que l’achat de 100 000 actions soit modeste par rapport à la position de 12,35 millions d’actions, ce nouvel achat peut être interprété par les investisseurs comme un vote de confiance envers Codexis aux niveaux de prix actuels. Aucune transaction sur dérivés, vente ou option n’a été divulguée dans ce dépôt.

Codexis, Inc. (CDXS) erhielt eine Form 4-Meldung von Opaleye Management Inc., einem 10%igen wirtschaftlichen Eigentümer, die einen am 27. Juni 2025 abgeschlossenen Kauf am offenen Markt beschreibt.

  • Transaktion: 100.000 Aktien der Codexis-Stammaktien wurden zum Durchschnittspreis von 2,39 $ pro Aktie gekauft (Code P).
  • Bestand nach der Transaktion: Opaleye hält nun indirekt 12.350.000 Aktien über Opaleye, L.P. sowie weitere 250.000 Aktien in einem separat verwalteten Konto, womit sich der gemeldete wirtschaftliche Gesamtbesitz auf 12,6 Millionen Aktien summiert.
  • Eigentumsform: Alle Aktien werden als indirekt (Formular I) gemeldet; der Investmentmanager lehnt eine wirtschaftliche Eigentümerschaft über sein finanzielles Interesse hinaus ab.
  • Status der meldenden Partei: Opaleye wird als 10%-Գü eingestuft; keine Vorstandsfunktion oder geschäftsführende Rolle wird angegeben.

Die Meldung signalisiert eine schrittweise Insider-Akkumulation durch einen Großaktionär. Obwohl der Kauf von 100.000 Aktien im Verhältnis zur Position von 12,35 Millionen Aktien gering ist, kann der frische Kauf von Investoren als Vertrauensbeweis in Codexis zu den aktuellen Kursniveaus interpretiert werden. In dieser Meldung wurden keine Derivatgeschäfte, Verkäufe oder Optionen offengelegt.

Positive
  • 10% owner purchased 100,000 shares at $2.39, signalling confidence and raising total indirect stake to 12.35 million shares.
Negative
  • None.

Insights

TL;DR 10% owner Opaleye adds 100 k shares, lifting indirect stake to 12.35 m; modest but positive insider-buy signal.

Analysis: The $2.39 purchase price sits near recent lows, implying the investor views shares as undervalued. Although the incremental buy represents less than 1% of Opaleye’s existing position, continued accumulation by a fund already above the 10% threshold can bolster market sentiment. No sales or hedges were reported, reducing concerns of near-term distribution. Absent earnings data, the purchase is a standalone bullish indicator rather than confirmation of fundamental improvement.

TL;DR Additional indirect insider purchase strengthens alignment but retains disclaimer of true beneficial ownership.

The filing underscores sustained economic exposure by Opaleye without altering governance dynamics—no board seat, no direct control. Indirect holding structure limits transparency, yet repeated open-market buying typically aligns interests with minority shareholders. The absence of derivative grants or preferential terms suggests market-rate acquisition, lowering agency-risk concerns. Overall governance impact: mildly positive.

Codexis, Inc. (CDXS) ha ricevuto una comunicazione Form 4 da Opaleye Management Inc., un azionista con una partecipazione del 10%, che dettaglia un acquisto sul mercato aperto completato il 27 giugno 2025.

  • Transazione: 100.000 azioni ordinarie di Codexis sono state acquistate (Codice P) a un prezzo medio di 2,39 $ per azione.
  • Detenzione post-transazione: Opaleye dichiara ora di detenere indirettamente 12.350.000 azioni tramite Opaleye, L.P. e ulteriori 250.000 azioni in un conto gestito separatamente, portando la proprietà beneficiaria totale a 12,6 milioni di azioni.
  • Forma di proprietà: Tutte le azioni sono riportate come indirette (Modulo I); il gestore degli investimenti nega la proprietà beneficiaria oltre il suo interesse pecuniario.
  • Stato della parte che segnala: Opaleye è classificata come azionista con oltre il 10%; non sono indicati ruoli nel consiglio o esecutivi.

La comunicazione indica un accumulo incrementale da parte di un grande azionista interno. Sebbene l'acquisto di 100.000 azioni sia modesto rispetto alla posizione di 12,35 milioni di azioni, il nuovo acquisto può essere interpretato dagli investitori come un segnale di fiducia in Codexis ai livelli di prezzo attuali. In questa comunicazione non sono state divulgate transazioni su derivati, vendite o opzioni.

Codexis, Inc. (CDXS) recibió una presentación Formulario 4 de Opaleye Management Inc., un propietario beneficiario del 10%, detallando una compra en el mercado abierto completada el 27 de junio de 2025.

  • հԲó: Se compraron 100,000 acciones ordinarias de Codexis (Código P) a un precio promedio de $2.39 por acción.
  • Posición posterior a la transacción: Opaleye reporta ahora 12,350,000 acciones mantenidas indirectamente a través de Opaleye, L.P. y otras 250,000 acciones en una cuenta gestionada por separado, sumando una propiedad beneficiaria total de 12.6 millones de acciones.
  • Forma de propiedad: Todas las acciones se reportan como indirectas (Formulario I); el administrador de inversiones renuncia a la propiedad beneficiaria más allá de su interés pecuniario.
  • Estado de la parte que informa: Opaleye está clasificada como un propietario del 10%; no se indica ningún rol en la junta o ejecutivo.

La presentación señala una acumulación incremental por parte de un gran accionista interno. Aunque la compra de 100,000 acciones es modesta en relación con la posición de 12.35 millones de acciones, la compra reciente puede interpretarse por los inversores como un voto de confianza en Codexis a los niveles de precio actuales. No se divulgaron transacciones con derivados, ventas u opciones en esta presentación.

Codexis, Inc. (CDXS)� 10% 지� 보유자인 Opaleye Management Inc.로부� 2025� 6� 27� 완료� 공개 시장 매수� 관� Form 4 신고� 받았습니�.

  • 거래 내용: Codexis 보통� 100,000주가 주당 평균 가� $2.39매수(코드 P)되었습니�.
  • 거래 � 보유 현황: 貹� 현재 Opaleye, L.P.� 통해 간접적으� 12,350,000주를 보유하고 있으�, 별도� 관리되� 계좌� 추가� 250,000주를 보유하여 � 보고� 실질 소유 지분은 1,260� �입니�.
  • 소유 형태: 모든 주식은 간접 소유(Form I)� 보고되었으며, 투자 매니저� 금전� 이익 이상� 실질 소유권을 부인합니다.
  • 신고� 상태: 貹� 10% 소유�� 분류되며, 이사회나 경영� 역할은 명시되어 있지 않습니다.

이번 신고� 대주주� 의한 점진적인 내부� 매입 신호입니�. 10� � 매수� 1,235� � 보유 규모� 비해 적은 편이지�, 신규 매수� 투자자들에게 현재 가� 수준에서 Codexis� 대� 신뢰� 표시� 해석� � 있습니다. 이번 신고에는 파생상품 거래, 매도 또는 옵션 거래� 포함되지 않았습니�.

Codexis, Inc. (CDXS) a reçu un dépôt de formulaire 4 de la part de Opaleye Management Inc., un détenteur bénéficiaire à 10%, détaillant un achat sur le marché libre réalisé le 27 juin 2025.

  • Transaction : 100 000 actions ordinaires de Codexis ont été achetées (Code P) à un prix moyen de 2,39 $ par action.
  • Positions après transaction : Opaleye déclare désormais détenir indirectement 12 350 000 actions via Opaleye, L.P. et un compte géré séparément avec 250 000 actions supplémentaires, portant la propriété bénéficiaire totale déclarée à 12,6 millions ’aپDzԲ.
  • Forme de propriété : Toutes les actions sont déclarées comme indirectes (Formulaire I) ; le gestionnaire d’investissement décline toute propriété bénéficiaire au-delà de son intérêt pécuniaire.
  • Statut du déclarant : Opaleye est classé comme un détenteur de 10% ; aucun rôle au conseil d’administration ou exécutif n’est indiqué.

Le dépôt signale une accumulation progressive d’initiés par un grand actionnaire. Bien que l’achat de 100 000 actions soit modeste par rapport à la position de 12,35 millions d’actions, ce nouvel achat peut être interprété par les investisseurs comme un vote de confiance envers Codexis aux niveaux de prix actuels. Aucune transaction sur dérivés, vente ou option n’a été divulguée dans ce dépôt.

Codexis, Inc. (CDXS) erhielt eine Form 4-Meldung von Opaleye Management Inc., einem 10%igen wirtschaftlichen Eigentümer, die einen am 27. Juni 2025 abgeschlossenen Kauf am offenen Markt beschreibt.

  • Transaktion: 100.000 Aktien der Codexis-Stammaktien wurden zum Durchschnittspreis von 2,39 $ pro Aktie gekauft (Code P).
  • Bestand nach der Transaktion: Opaleye hält nun indirekt 12.350.000 Aktien über Opaleye, L.P. sowie weitere 250.000 Aktien in einem separat verwalteten Konto, womit sich der gemeldete wirtschaftliche Gesamtbesitz auf 12,6 Millionen Aktien summiert.
  • Eigentumsform: Alle Aktien werden als indirekt (Formular I) gemeldet; der Investmentmanager lehnt eine wirtschaftliche Eigentümerschaft über sein finanzielles Interesse hinaus ab.
  • Status der meldenden Partei: Opaleye wird als 10%-Գü eingestuft; keine Vorstandsfunktion oder geschäftsführende Rolle wird angegeben.

Die Meldung signalisiert eine schrittweise Insider-Akkumulation durch einen Großaktionär. Obwohl der Kauf von 100.000 Aktien im Verhältnis zur Position von 12,35 Millionen Aktien gering ist, kann der frische Kauf von Investoren als Vertrauensbeweis in Codexis zu den aktuellen Kursniveaus interpretiert werden. In dieser Meldung wurden keine Derivatgeschäfte, Verkäufe oder Optionen offengelegt.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Opaleye Management Inc.

(Last) (First) (Middle)
ONE BOSTON PLACE, 26TH FLOOR

(Street)
BOSTON MA 02108

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
CODEXIS, INC. [ CDXS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
06/27/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $0.001 per share 06/27/2025 P 100,000 A $2.39 12,350,000 I By Opaleye, L.P.(1)(3)
Common Stock, par value $0.001 per share 250,000 I By Managed Account(2)(3)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.
3. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Opaleye Management Inc., By: /s/ James Silverman, President 07/01/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many Codexis (CDXS) shares did Opaleye buy on 27 June 2025?

100,000 shares of common stock were purchased.

What was the purchase price for the insider transaction in CDXS?

The shares were acquired at $2.39 per share.

What is Opaleye’s total reported ownership in Codexis after the transaction?

Opaleye reports 12,350,000 shares via Opaleye, L.P. plus 250,000 in a managed account.

Did the Form 4 include any stock sales or derivative transactions?

No. The filing discloses only a purchase of common stock and reports no derivatives or sales.

Why is Opaleye considered a 10% owner of Codexis?

Its aggregated indirect holdings exceed 10% of Codexis� outstanding common stock, triggering Section 16 reporting.
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